PROGNOSTIC SIGNIFICANCE OF NUCLEAR ANALYSIS IN INVASIVE CARCINOMA OF CERVIX PATIENTS TREATED BY PRIMARY RADIATION
スポンサーリンク
概要
- 論文の詳細を見る
The value of microspectrophotometric analysis was studied for the assessment of prognosis in patients with squamous cell carcinoma of the cervix treated with primary radiation therapy. Cellular nuclear desoxyribonucleic acid (DNA) content and nuclear size were measured in smears taken before, during and immediately after radiation therapy. Additional determination of DNA content/nuclear size ratio was made. Changing patterns of DNA distribution, nuclear size and their ratio were classified into Type I, II, 111, and IV, according to the mode of their shifts in the course of radiation therapy.The results showed diploid (47%), polyploid (23%) and aneuploid (30%) DNA distribution in pre-treated carcinomas.Particularly, the results showed a distinct correlation between the type of histograms and patient outcome.Patients with Type 11 histograms (initial shift to the right and posterior shift to the left) showed a better survival rate and no recurrences compared with other types. On the other hand, patients with Type III histograms (initial shift to the left and posterior shift to the right) had poor prognosis and were predominant among dead cases with radioresistant tumors. These results suggested the potential usefulness of cytophotometric analysis for assessing prognosis in advanced cases.
- 社団法人日本産科婦人科学会の論文
- 1986-02-01
著者
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Ohta Masahiro
Department Of Cardiology Mie University Graduate School Of Medicine
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Tomoda Yutaka
Department Of Biopharmaceutics Kyoto Pharmaceutical University
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Tomoda Yutaka
Department Of Obstetrics And Gyleecology Nagoya University School Of Medicine
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SAKAKIBARA Katsumi
Faculty of Computer Science and System Engineering, Okayama Prefectural University
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Sakakibara Katsumi
The Faculty Of Computer Science & System Engineering Okayama Prefectural University
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Sakakibara Katsumi
Department Of Communication Engineering Okayama Prefectural University
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Sakakibara Katsumi
Department Of Obstetrics And Gyleecology Nagoya University School Of Medicine
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Hector A
Department Of Obstetrics And Gyleecology Nagoya University School Of Medicine
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Nishida Yuichi
Department Of Obstetrics And Gyleecology Nagoya University School Of Medicine
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Nishida Yuichi
Department Of Gynecology And Obstetrics Hekinan Municipal Hospital
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KANO Takeo
Department of Obstetrics and Gyleecology, Nagoya University School of Medicine
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ISHIHARA Tsuneaki
Department of Obstetrics and Gyleecology, Nagoya University School of Medicine
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Kano Takeo
Department Of Obstetrics And Gyleecology Nagoya University School Of Medicine
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Ohta Masahiro
Department Of Obstetrics And Gyleecology Nagoya University School Of Medicine
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Ishihara Tsuneaki
Department Of Obstetrics And Gyleecology Nagoya University School Of Medicine
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Sakakibara Katsumi
Department of Chemistry, Faculty of Science, Nagoya University
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