Sporadic Adult-onset Hypophosphatemic Osteomalacia Caused by Excessive Action of Fibroblast Growth Factor 23
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概要
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A 50-year-old man without family history of metabolic bone disease was referred to our hospital with a 5-year history of progressively worsening spinal and bilateral diffuse leg pain and proximal muscle weakness. Two years before admission, he was diagnosed as ankylosing spondylitis by a rheumatologist and was maintained on low-dose prednisone therapy without benefit. He developed progressive spinal and thoracic deformities, resulting in a 10 cm loss in height in the preceding 2 years. On physical examination, marked thoracic kyphosis and pectus carinatum was noted. Plain radiograph revealed pseudofracture in the right femoral neck. Laboratory findings showed a normal level of serum calcium, elevated level of serum alkaline phosphatase and inappropriately increased urinary phosphate excretion despite extreme hypophosphatemia. He was diagnosed as adult-onset hypophosphatemic osteomalacia caused by renal phosphate wasting. Serum fibroblast growth factor 23 was the upper limit of normal despite extreme hypophosphatemia and no neoplastic lesion potentially inducing hypophosphatemic osteomalacia could be identified in a thorough search including imaging studies of his entire body. Oral administration of phosphate and activated vitamin D together with dipyridamole relieved the persistent pain and weakness, and he became fully ambulatory.
- 社団法人 日本内科学会の論文
著者
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Ohta Masahiro
Department Of Cardiology Mie University Graduate School Of Medicine
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Satoh Noriyuki
Department Of Biology Niigata University
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Kuriyama Chizuko
Department Of Medicine Ohta General Hospital
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Satoh Noriyuki
Department of General Internal Medicine, Ohta-Nishinouchi Hospital
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Hoshino Chisho
Department of General Internal Medicine, Ohta-Nishinouchi Hospital
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Sugawara Shinichi
Department of General Internal Medicine, Ohta-Nishinouchi Hospital
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Kikuchi Akio
Department of General Internal Medicine, Ohta-Nishinouchi Hospital
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Ohta Masahiro
Department of General Internal Medicine, Ohta-Nishinouchi Hospital
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Kuriyama Chizuko
Department of General Internal Medicine, Ohta-Nishinouchi Hospital
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