INACTIVATION OF OXYTOCIN AND ANGIOTENSIN II BY PLACENTAL LEUCINE AMINOPEPTIDASE(P-LAP)
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概要
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胎盤後血および胎盤後血から精製したplacetal leucine aminopeptidase(以下P-LAPと略す)のオキシトシンとアンヂオテンシンII分解能をバイオアッセイにより比較検討し,妊婦血中に著増するP-LAPの生理的意義の一端に考察を加えた.正常妊婦胎盤後血およびそれから3.450倍純化精製され,ポリアクリルアミドゲル電気泳動上活性および蛋白質として単一なバンドを示す精製P-LAPを使用した.オキシトシナーゼはHoltonの方法,アンヂオテンシナーゼは国府の方法によりそれぞれバイオアッセイにより測定した.P-LAP活性はメチオニン非感受性LAPとして著者らの方法により行った.オキシトシナーゼ活性/P-LAP活性の比が胎盤後血は2.26で精製P-LAPでは5.45,アンヂオテンシナーゼ活性/P-LAP活性の比が胎盤後血は0.63で精製P-LAPでは3.11とそれぞれ上昇した.このように,バイオアッセイ/P-LAP活性の比が胎盤後血よりも精製P-LAPの方が数倍高いことから,妊婦血中にはP-LAPの他にもオキシトシンやアンヂオテンシンII分解作用を持つ物質の存在が推定されるし,又P-LAPの阻害物質の存在等も考えられる.胎盤後血と精製P-LAPのオキシトシンおよびアンヂオテンシンII分解能がバイオアッセイにより明らかとなったことから,本酵素は妊婦血中でオキシトシンやアンヂオテンシンIIの血中レベルの調節に関与し,妊娠維持に重要な働きをすることが考えられる.
- 社団法人日本産科婦人科学会の論文
- 1982-04-01
著者
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Mizutanl Shigehiko
Department Of Obstetrics And Gynecology. Rinko Hospital. Nagoya
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NOTO Hiroshi
Department of Diabetes and Metabolism, Tokyo University Hospital
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Noto Hiroshi
Department Of Obstetrics And Gynecology Hamamatsu University School Of Medicine. Hamamatsu
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Noto Hiroshi
Department Of Diabetes And Metabolism Tokyo University Hospital
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Mizutani Shigehiko
Department Of Obstetrics And Gynaecology Nagoya University Graduate School Of Medicine
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SAKURA Harutake
Department of Obstetrics and Gynecology. Hamamatsu Medical Center. Hamamatsu
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INAMOTO Yutaka
Department of Obstetrics and Gynecology Hamamatsu University School of Medicine. Hamamatsu
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KAWASHIMA Yoshiro
Department of Obstetrics and Gynecology Hamamatsu University School of Medicine. Hamamatsu
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Kawashima Yoshiro
Department Of Obstetrics And Gynecology Hamamatsu Universily School Of Medicine
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Sakura Harutake
Department Of Obstetrics And Gynecology Hamamatsu Medical Center
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Mizutanl Shigehiko
Department Of Obstetrics And Gynecology Rinko Hospital
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Noto Hiroshi
Department Of Diabetes And Metabolic Medicine Diabetes Research Center National Center For Global Health And Medicine
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