The Reproductive Effects in Rats after Chronic Oral Exposure to Low-dose Depleted Uranium

スポンサーリンク

概要

• 論文の詳細を見る

• This two-generation study evaluated the effects of depleted uranium (DU) on reproduction in rats. Across two generations, Wistar rats (30/sex/group) were maintained on feed containing DU at dose levels of 0 (control group), 4 (DU4 group), or 40 (DU40 group) mg kg–1 day–1 for 4 months prior to mating. After 4 months of exposure, the pregnancy rate, normal labour rate, and survival rate of offspring produced by F1 rats were all significantly decreased as compared to the control group, and especially in the DU40 group, these parameters fell by half to two-thirds, while no adverse effects were evident in F0 rats. The uranium content in the testes and ovaries of F1 rats in the DU4 and DU40 groups was significantly higher than that found in F0 rats. The levels of sex hormone in the serum were disorder in both generations. The enzymes related to spermiogenesis were also significantly different between generations, and the damage was more severe in F1 rats. In conclusion, the reproductive effects in F0 rats were slight after chronic oral exposure to DU, while the effects were obvious in F1 rats.

著者

• Xu Hui

  State Key Laboratory Of Trauma Burns And Combined Injury Institute Of Combined Injury College Of Pre

• CHENG Tianmin

  State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of

• Li Rong

  State Key Laboratory Of Trauma Burns And Combined Injury Institute Of Combined Injury College Of Pre

• Hao Yuhui

  State Key Laboratory Of Trauma Burns And Combined Injury Institute Of Combined Injury College Of Pre

• Ren Jiong

  State Key Laboratory Of Trauma Burns And Combined Injury Institute Of Combined Injury College Of Pre

• Ai Guoping

  State Key Laboratory Of Trauma Burns And Combined Injury Institute Of Combined Injury College Of Pre

• Su Yongping

  State Key Laboratory Of Trauma Burns And Combined Injury Institute Of Combined Injury College Of Pre

• Liu Jing

  State Key Laboratory Of Freshwater Ecology And Biotechnology Institute Of Hydrobiology Chinese Acade

• XU Hui

  State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University

• LIU Jing

  State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University

• CHENG Tianmin

  State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University

• LENG Yanbine

  State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University

関連論文

• Upstream Regulatory Region of Zebrafish lunatic fringe : Isolation and Promoter Analysis
• A study Assessing the Genotoxicity in Rats after Chronic Oral Exposure to a Low Dose of Depleted Uranium
• SL-1-1 The intestinal injuries by radiation, and the related work in China(Radiation Biology Research in Asia, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• ERp29 is a Radiation-Responsive Gene in IEC-6 Cell
• Involvement of Peroxiredoxin I in Protecting Cells from Radiation-Induced Death
• The Reproductive Effects in Rats after Chronic Oral Exposure to Low-dose Depleted Uranium

スポンサーリンク