Fcr1p Inhibits Development of Fluconazole Resistance in Candida albicans by Abolishing CDR1 Induction(Pharmacology)
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概要
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Overexpression of Candida drug resistance 1 (CDR1) gene in Candida albicans (C. albicans), an efflux pump, is one of the major mechanisms contributing to drug resistance. C. albicans for fluconazole resistance 1 protein (Fcr1p) is a member of the family of zinc cluster proteins homologous to Pdr1p and Pdr3p (pleiotropic drug resistance protein) mediating azole resistance in Saccharomyces cerevisiae (S. cerevisiae) by regulating the expression of pleiotropic drug resistance 5 (PDR5) homologous to C. albicans CDR1 A previous study has showed that for fluconazole resistance 1 (FCR1) could also confer azole resistance in S. cerevisiae pdr1 pdr3 mutant by regulating PDR5. Therefore, we investigated the role of FCR1 in the development of C. albicans azole resistance in vitro and in vivo. Our results showed that Fcr1p inhibited fluconazole (FLC) resistance development in C. albicans through abolishing the induction of CDR1 expression by FLC, and in contrast FLC resistance development was accelerated resulting from the deletion of FCR1.
- 2007-01-01
著者
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Cao Yong
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Gao Ping
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Zhang Jun
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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XU Zheng
Department of Pharmacology, College of Pharmacy, Second Military Medical University
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Jiang Yuan
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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SHEN Hui
Department of Applied Chemistry, Graduate School of Engineering, Tokyo Metropolitan University
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An Mao-mao
Department Of Clinical Pharmacology Chinese People's Liberation Army General Hospital
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An Mao
Department Of Pharmacology College Of Pharmacy Second Military Medical University
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Xu Zheng
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Shen Hui
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Shen Hui
Department Of Applied Chemistry Graduate School Of Engineering Tokyo Metropolitan University
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Gao Ping-Hui
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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Cao Ying-Ying
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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Cao Yong-Bing
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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Jiang Yuan-Ying
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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WANG De
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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ZHANG Jun-Dong
Department of Pharmacology, School of Pharmacy, Second Military Medical University
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Wang De
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Cao Ying
School Of Pharmacy Second Military Medical University
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Xu Zheng
Department Of Pharmacology College Of Pharmacy Second Military Medical University
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Cao Yong-bing
School Of Pharmacy Second Military Medical University
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Gao Ping-hui
School Of Pharmacy Second Military Medical University
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Zhang Jun-dong
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Xu Zheng
Department Of Biochemistry And National Laboratory Of Pharmaceutical Biotechnology Nanjing Universit
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Wang De
Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore
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