Chemical Synthesis and Biological Activity of The Gelatinase Biosynthesis-Activating Pheromone of Enterococcus faecalis and Its Analogs(Organic Chemistry)
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概要
- 論文の詳細を見る
An 11-residue peptide lactone, termed the gelatinase biosynthesis-activating pheromone (GBAP), triggers the production of the pathogenicity-related extracellular proteases, gelatinase and serine protease, in Enterococcus faecalis. In this study, we synthesized GBAP and its analogs and examined their gelatinase biosynthesis-inducing activity. This study on the structure-activity relationship shows that a lactone ring was indispensable for the activity.
- 社団法人日本農芸化学会の論文
- 2001-10-23
著者
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作田 庄平
東京大学大学院農学生命科学研究科応用生命化学専攻
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Sakuda S
Department Of Applied Biological Chemistry The University Of Tokyo
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Nagasawa Hiromichi
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Nakayama Jiro
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
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Cao Yong
Department Of Pharmacology School Of Pharmacy Second Military Medical University
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Nakayama J
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Nakayama Jiro
Lab. Of Microbial Technol. Div. Of Microbial Sci. And Technol. Dep. Of Bioscience And Biotechnology
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Nakayama Jiro
Laboratory Of Microbial Technology Division Of Microbial Science And Technology Department Of Biosci
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Nakayama Jiro
Department Of Applied Biological Chemistry Graduate School Of Agriculture And Life Sciences The Univ
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Nagao Jun-ichi
Dep. Of Functional Bioscience Section Of Infection Biology Fukuoka Dental Coll. 2-15-1 Tamura Sawara
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Nagao Jun-ichi
Department Of Functional Bioscience Section Of Infection Biology Fukuoka Dental College
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SAKUDA Shohei
Department of Applied Biological Chemistry, University of Tokyo
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Sakuda Shohei
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Nagasawa Hiromichi
Graduate School Of Agricultural And Life Sciences University Of Tokyo
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Nagasawa Hiromichi
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Nagasawa Hiromichi
Department Of Applied Biological Chmistry Graduate School Of Agricultural And Life Sciences The Univ
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Nakayama Jiro
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Cao Y
Department Of Chemistry & Shanghai Key Laboratory Of Molecular Catalysis And Innovative Material
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Horii Takaaki
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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作田 庄平
東大 大学院
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Cao Yong
Department Of Chemistry Fudan University
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Cao Yong
Department of Chemistry & Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University
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SAKUDA Shohei
Department of Agricultural Chemistry, The University of Tokyo
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NAKAYAMA Jiro
Department of Agricultural Chemistry, The University of Tokyo
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