Reduction of the Acyl Group: The Critical Step in Bombykol Biosynthesis That Is Regulated in Vitro by the Neuropeptide Hormone in the Pheromone Gland of Bombyx mori

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概要

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• The sex pheromone of Bombyx mori, bombykol [(10E, 12Z)-10,12-hexadecadien-1-ol], can be biosynthesized in four steps: construction of a hexadecanoic moiety from acetyl CoA, Δ-11-desaturation, Δ-10,12-desaturation, and reduction of the acyl group. This biosynthesis is regulated by a hormone named the pheromone biosynthesis activating neuropeptide (PBAN). To examine the steps that are accelerated by this neurohormone, pheromone glands excised from decapitated females were incubated in vitro with either ^<14>C-labeled sodium acetate or one of three fatty acids [hexadecanoic acid, (Z)-11-hexadecenoic acid, or (10E, 12Z)-10,12-hexadecadienoic acid]. After analyzing the radioactivity that was incorporated from each precursor into bombykol and the biosynthetic precursors, it was observed that the first three steps proceeded in glands both treated and untreated with synthetic PBAN of B. mori; however, the last step proceeded only in the treated glands. From this in vitro experiment, it can be concluded that the main regulatory role of PBAN is in the reduction of the acyl group in B. mori, as was shown by our previous in vivo experiment.

• 社団法人日本農芸化学会の論文
• 1993-12-23

著者

• Suzuki A

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Suzuki Akinori

  Department Of Agricultural Chemistry The University Of Tokyo

• Nagasawa Hiromichi

  Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U

• Kataoka Hiroshi

  Department of Applied Chemistry and Biotechnology, Niigata Institute of Technology

• Ando T

  Department Of Applied Biological Science Faculty Of Agriculture Tokyo University Of Agriculture And

• Kataoka H

  Univ. Tokyo Tokyo Jpn

• Ando Tomoaki

  Division Of Bioscience And Biotechnology Department Of Ecological Engineering Toyohashi University O

• ANDO Tetsu

  Department of Plant Protection, Faculty of Agriculture, Tokyo University of Agriculture and Technolo

• Ozawa A.

  Department Of Applied Biological Science Faculty Of Agriculture Tokyo University Of Agriculture And

• Kodama Hisashi

  Central Research Institute Japan Tabacco Inc.

• Kataoka Hiroshi

  Institute Of Applied Biochemistry University Of Tsukada

• Suzuki Akinori

  Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo

• Suzuki Atsushi

  Basic Research Department Prima Meat Packers Co. Ltd.

• Nagasawa Hiromichi

  Graduate School Of Agricultural And Life Sciences University Of Tokyo

• Nagasawa Hiromichi

  Department Of Applied Biological Chemistry Graduate School Of Agriculture And Life Sciences Universi

• Nagasawa Hiromichi

  Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo

• Suzuki A

  Department Of Obstetrics And Gynecology Keio University School Of Medicine

• Ando T

  Graduate School Of Bio-applications And Systems Engineering (base) Tokyo University Of Agriculture A

• Ando Tetsu

  Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo

• Suzuki Akinori

  Chemistry Faculty Of Agriculture The University Of Tokyo

• Ando Tetsu

  Graduate School Of Bio-applications And Systems Engineering Tokyo University Of Agriculture And Tech

• Kataoka Hiroshi

  Department Of Applied Biological Technology The University Of Tokyo

• Suzuki A

  Faculty Of Agriculture The University Of Tokyo

• KATAOKA Hiroshi

  Department of Agricultural Chemistry, The University of Tokyo

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