Sesquiterpene Aminoquinones, from a Marine Sponge, Induce Erythroid Differentiation in Human Chronic Myelogenous Leukemia, K562 Cells

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概要

• 論文の詳細を見る

• A new sesquiterpene aminoquinone, 5-epi-smenospongorine, together with nine known sesquiterpene quinone/phenols, was isolated as differentiation-inducing substances to K562 cells into erythroblast from the marine sponge Dactylospongia elegans. The structure-activity relationship study of these compounds clarified that the quinone skeleton is indispensable and the amino group plays an important role for their differentiation-inducing activity to K562 cells into erythroblast.

• 社団法人日本薬学会の論文
• 2004-08-01

著者

• Akiyama Shin-ichi

  鹿児島大学 医歯学総合研究科分子腫瘍学

• Akiyama Shin-ichi

  大阪大学 薬研究

• Akiyama S

  Department Of Molecular Oncology Graduate School Of Medical And Dental Sciences Kagoshima University

• Akiyama Shin-ichi

  The Institute Of Chemotherapy Kagoshima University Faculty Of Medicine

• Akiyama Shin-ichi

  Department Of Cancer Chemotherapy Institute For Cancer Research

• AOKI Shunji

  Graduate School of Pharmaceutical Sciences, Osaka University

• KOBAYASHI Motomasa

  Graduate School of Pharmaceutical Sciences, Osaka University

• RACHMAT Rachmaniar

  Research and Development Centre for Oceanology, LIPI

• Aoki S

  Graduate School Of Pharmaceutical Sciences Osaka University

• Aoki Shunji

  Graduate School Of Pharmaceutical Sciences Osaka University

• Akiyama Shin-ichi

  Department Of Cancer Chemotherapy Institute For Cancer Research Faculty Of Medicine Kagoshima Univer

• KONG Dexin

  Graduate School of Pharmaceutical Sciences, Osaka University

• MATSUI Kouhei

  Graduate School of Pharmaceutical Sciences, Osaka University

• Kobayashi M

  Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North

• Aoki Shinji

  Research Laboratory Taisho Pharmaceutical Co. Ltd.

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Osaka University

• Kobayashi Masao

  Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.

• Rachmat Rachmaniar

  Research And Development Centre For Oceanology Lipi

• Kobayashi M

  Graduate School Of Pharmaceutical Sciences Osaka University

• Matsui K

  Graduate School Of Pharmaceutical Sciences Osaka University

• Kong Dexin

  Graduate School Of Pharmaceutical Sciences Osaka University

• 小林 資正

  Graduate School Of Pharmaceutical Sciences Osaka University

• Kobayashi Motomasa

  Graduate School Of Pharmaceutical Sciences Osaka Univ.

• Kawaguchi M

  Graduate School Of Pharmaceutical Sciences Osaka University

• Matsui Kazuki

  Sumitomo Pharmaceuticals Research Division

• Aoki Shunji

  Graduate School Of Industrial Engineering Tokai University

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