19 沖縄産Theonella属海綿2種の産生するアミノセスキテルペン類および生物活性ペプチドラクトン類の化学構造

概要

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In search of new bioactive substances from marine organisms, we have investigated the chemical constituents of two Okinawan marine sponges of Theonella sp. (Theonellidae). 1) Aminosesquiterpenes From the acetone extract of a marine sponge of Theonella sp. (Theo-84-HM-1), which was collected in the coral reef of Hatomajima, Okinawa Prefecture, four new aminosesquiterpenes: aminobisabolene (1), aminobisabolenol (2), isoaminobisabolenol-a (3), and isoaminobisabolenol-b (4), were isolated. Based on the chemical and physicochemical evidence, including the X-ray analysis of the bromoacetate (1a) of 1, their absolute stereostructures have been determined. 2) Theonellapeptolides From the EtOAc soluble portion of the acetone extract of a marine sponge of Theonella sp. (Theo-83-ZM-1), which was collected in the coral reef of Zamamijima, Okinawa Prefecture, five new peptolides: theonellapeptolides Ia (10), Ib (11), Ic (12), Id (13), and Ie (14), were isolated. These peptolides inhibit development of the fertilized eggs of the sea urchin Hemicentrotus pulcherrimus. The structure of the major peptolide, theonellapeptolide Id (13), has been determined on the basis of chemical and physicochemical evidence. Theonellapeptolide Id (13) is a characteristic tridecapeptolide which comprises N-methyl and D amino acids in high ratio.
天然有機化合物討論会の論文
1986-09-09