Marine Natural Products. XXXVIII. Absolute Stereostructures of Altohyrtins A, B, and C and 5-Desacetylaltohyrtin A, Potent Cytotoxic Macrolides, from the Okinawan Marine Sponge Hyrtios altum

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概要

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• Altohyrtins A (1), B (2), and C (3) and 5-desacetylaltohyrtin A (4), extremely potent cytotoxic macrolides, have been isolated from the Okinawan marine sponge Hyrtios altum. The absolute stereostructures of these macrolides have been elucidated on the bases of detailed NMR analysis, application of the modified α-methoxy-α-(trifluoromethyl)phenylacetic acid (MTPA) method to the hexa-MTPA esters, and application of the circular dichroism (CD) exciton chirality method.

• 公益社団法人日本薬学会の論文
• 1996-11-15

著者

• Akiyama Shin-ichi

  大阪大学 薬研究

• 北川 勲

  大阪大学

• Akiyama Shin-ichi

  The Institute Of Chemotherapy Kagoshima University Faculty Of Medicine

• Aoki S

  Graduate School Of Pharmaceutical Sciences Osaka University

• Kitagawa Isao

  Faculty Of Pharmaceutical Sciences Osaka University:(present Address)kinki University

• KOBAYASHI Motomasa

  Faculty of Pharmaceutical Sciences, Osaka University

• Kobayashi M

  Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North

• AOKI Shunji

  Faculty of Pharmaceutical Sciences, Osaka University

• Aoki Shinji

  Research Laboratory Taisho Pharmaceutical Co. Ltd.

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Osaka University

• Kobayashi Motomasa

  Faculty Of Pharmaceutical Sciences

• Kobayashi Masao

  Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.

• Kitagawa Isao

  Faculty Of Pharmaceutical Sciences

• Gato Katsuhiko

  Faculty Of Pharmaceutical Sciences Osaka University

• 小林 資正

  Graduate School Of Pharmaceutical Sciences Osaka University

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