Bioactive Saponins and Glycosides. III. Horse Chestnut. (1) : The Structures, Inhibitory Effects on Ethanol Absorption, and Hypoglycemic Activity of Escins Ia, Ib, IIa, IIb, and IIIa from the Seeds of Aesculus hippocastanum L.
スポンサーリンク
概要
- 論文の詳細を見る
Five bioactive triterpene oligoglycosides named escins Ia, Ib, IIa, IIb, and IIIa were isolated from the seeds of horse chestnut tree, Aesculus hippocastanum L. (Hippocastanaceae). The chemical structures of escins Ia, Ib, IIa, IIb, and IIIa were determined on the basis of chemical and physicochemical evidence, which included selective cleavage of the glucuronide linkage using photochemical reaction and lead tetraacetate decarboxylation reaction. Escins Ia, Ib, IIa, and IIb were found to exhibit an ethanol absorption-inhibitory effect and hypoglycemic activity in the oral glucose tolerance test in rats. Some structure-activity relationships are reported.
- 公益社団法人日本薬学会の論文
- 1996-08-15
著者
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MATSUDA Hisashi
Kyoto Pharmaceutical University
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YOSHIKAWA Masayuki
Kyoto Pharmaceutical University
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北川 勲
大阪大学
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MURAKAMI Toshiyuki
Kyoto Pharmaceutical University
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MURAKAMI Nobutoshi
Kyoto Pharmaceutical University
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YAMAHARA Johji
Kyoto Pharmaceutical University
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村上 啓寿
阪大院薬:presto
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Kitagawa Isao
Faculty Of Pharmaceutical Sciences Osaka University:(present Address)kinki University
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Yamahara J
Kyoto Pharmaceutical University
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Kitagawa Isao
Faculty Of Pharmaceutical Sciences
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YAMAHARA JOHJI
Kyoto College of Pharmacy
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MATSUDA HISASHI
Kyoto College of Pharmacy
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Murakami Toshiyuki
Kyoto Institute of Technology
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