Haliclonacyclamines, Tetracyclic Alkylpiperidine Alkaloids, as Anti-dormant Mycobacterial Substances from a Marine Sponge of Haliclona sp.
スポンサーリンク
概要
- 論文の詳細を見る
A new tetracyclic alkylpiperidine alkaloid, 22-hydroxyhaliclonacyclamine B (1), together with two known alkaloids, haliclonacyclamine A (2) and B (3), were isolated from a marine sponge of Haliclona sp. as anti-dormant mycobacterial substances. The chemical structure of 22-hydroxyhaliclonacyclamine B (1) was determined on the basis of spectroscopic study. The compounds 2 and 3 showed strong anti-mycobacterial activity against Mycobacterium smegmatis and M. bovis Bacille de Calmette et Guérin (BCG) under both aerobic condition and hypoxic condition inducing dormant state with minimum inhibitory concentrations (MICs) in the ranges of 1.0—2.5 μg/ml. In addition, the anti-microbial activity of compound 3 was bactericidal against M. bovis BCG under both aerobic and hypoxic conditions. The 22-hydroxy group in 1 was found to reduce anti-mycobacterial activity, because 22-hydroxyhaliclonacyclamine B (1) exhibited weaker anti-microbial activities against Mycobacterium bacilli with MICs in the ranges of 12.5—50 μg/ml.
- 社団法人 日本薬学会の論文
著者
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KOBAYASHI Motomasa
Graduate School of Pharmaceutical Sciences, Osaka University
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Arai Masayoshi
Graduate School of Pharmaceutical Sciences, Osaka University
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Ishida Shunsuke
Graduate School of Pharmaceutical Sciences, Osaka University
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Setiawan Andi
Department of Chemistry, Faculty of Science, Lampung University
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Setiawan Andi
Department Of Chemistry Lampung University
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Kobayashi Motomasa
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Ishida Shunsuke
Graduate School Of Pharmaceutical Sciences University Of Tokushima
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Ishida Shunsuke
Graduate School Of Pharmaceutical Sciences Osaka University
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Arai Masayoshi
Graduate School Of Pharmaceutical Sciences Osaka University
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