Action-Mechanism of Trichoderin A, an Anti-dormant Mycobacterial Aminolipopeptide from Marine Sponge-Derived Trichoderma sp.
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概要
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In the course of our search for anti-dormant mycobacterial substances from marine organisms, we previously isolated three new aminolipopeptides, named trichoderins A, A1 and B, from the culture of the marine sponge-derived fungus of Trichoderma sp. and determined their chemical structures. To identify the gene that could confer a resistance to trichoderin A, we prepared transformants of Mycobacterium (M.) smegmatis, which were transformed with the genomic DNA library of M. bovis BCG constructed in the multi-copy shuttle cosmid pYUB145. Then, the transformant of M. smegmatis, which over-expressed a part of genes that coded mycobacterial ATP synthase, was found to exhibit a resistance to trichoderin A. In addition, trichoderin A reduced ATP contents in M. bovis BCG. These findings elucidated that the anti-mycobacterial activity of trichoderins comes from the inhibition of ATP synthesis.
- 公益社団法人 日本薬学会の論文
著者
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Arai Masayoshi
Graduate School of Pharmaceutical Sciences, Osaka University
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PRUKSAKORN Patamaporn
Graduate School of Pharmaceutical Sciences, Osaka University
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Kobayashi Motomasa
Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Liu Liu
Graduate School of Pharmaceutical Sciences, Osaka University
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Moodley Prashini
Nelson R. Mandela School of Medicine, University of KwaZulu Natal
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Jacobs Jr.
Howard Hughes Medical Institute, Price Translational Research Center, Albert Einstein College of Med
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Arai Masayoshi
Graduate School Of Pharmaceutical Sciences Osaka University
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Jacobs Jr.
Howard Hughes Medical Institute, Price Translational Research Center, Albert Einstein College of Medicine
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