Modulators of Tumor Necrosis Factor α Production Bearing Dicarba-closo-dodecaborane as a Hydrophobic Pharmacophore
スポンサーリンク
概要
- 論文の詳細を見る
Previous studies on the structural development of tumor necrosis factor α (TNF-α) production regulators derived from thalidomide (N-α-phthalimidoglutarimide) revealed that a hydrophobic substituent at the nitrogen atom of the phathalimide ring is critical for potent activity. We have designed and pepared phthalimide derivatives bearing a boron cluster, dicarba-closo-dodecaborane (carborane), which has a hydrophobic character and spherical geometry, as a novel candidate of biological response modifiers. These compounds were shown to regulate TNF-α production by HL-60 cells, as expected. The result provides a further example of the application of carborane as a hydrophobic pharmacophore of biologically active molecules.
- 公益社団法人日本薬学会の論文
- 2000-04-01
著者
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遠藤 泰之
東北薬科大学薬学部
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小磯 邦子
東大分生研
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HASHIMOTO Yuichi
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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Hashimoto Yuichi
Univ. Tokyo Tokyo Jpn
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Hashimoto Yuichi
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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ENDO Yasuyuki
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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TSUJI Motonori
Graduate School of Pharmaceutical Sciences, University of Tokyo
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TAKAHASHI Hiroyasu
Institute of Molecular and Cellular Biosciences, University of Tokyo
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KOISO Yukiko
Institute of Molecular and Cellular Biosciences, University of Tokyo
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Hashimoto Y
Graduate School Of Pharmaceutical Sciences Kyushu University
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Hashimoto Yuichi
Institute Of Molecular & Cellular Biosciences University Of Tokyo
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Takahashi H
Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Tsuji Motonori
Graduate School Of Pharmaceutical Sciences University Of Tokyo
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Endo Yasuyuki
Graduate School Of Pharmaceutical Sciences University Of Tokyo
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Takahashi Hiroyasu
Institute Of Molecular And Cellular Biosciences University Of Tokyo
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Takahashi Hiroyasu
Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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