Anti-Androgenic Activity of Substituted Azo- and Azoxy-Benzene Derivatives

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概要

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• Substituted phenylazo and phenylazoxy compounds were systematically prepared and their anti-androgenic activity was measured in terms of (1) the growth-inhibiting effect on an androgen-dependent cell line, SC-3,and (2) the binding affinity of nuclear androgen receptor. Generally, azo/azoxy compounds showed cell toxicity, and the growth-inhibiting effects on SC-3 cells correlated with the toxicity. However, some compounds, including 4,4'-dinitroazobenzene (25), 4,4'-dimethoxyazobenzene (33), and 2,2'-dichloroazoxybenzene (47), possessed potent anti-androgenic activity without apparent cell toxicity.

• 公益社団法人日本薬学会の論文
• 2000-11-01

著者

• 小磯 邦子

  東大分生研

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• SODEOKA Mikiko

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• TAKAHASHI Hiroyasu

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• KOISO Yukiko

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Takahashi H

  Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Sodeoka Mikiko

  Sagami Chemical Research Center

• ISHIOKA Toshiyasu

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• Ishioka Toshiyasu

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Takahashi Hiroyasu

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• Takahashi Hiroyasu

  Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Sodeoka Mikiko

  Institute for Chemical Reaction Science, Tohoku University

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