Glycogen Phosphorylase a Inhibitors with a Phenethylphenylphthalimide Skeleton Derived from Thalidomide-Related α-Glucosidase Inhibitors and Liver X Receptor Antagonists
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概要
- 論文の詳細を見る
Novel glycogen phosphorylase a (GPa) inhibitors with a phenethylphenylphthalimide skeleton were prepared based on α-glucosidase inhibitors and liver X receptor (LXR) antagonists derived from thalidomide. Their structure–activity relationships were analyzed. Some of the compounds thus prepared showed potent inhibitory activity against rabbit muscle GPa with more than 10-fold greater efficacy than a typical GPa inhibitor, 1,4-dideoxy-1,4-imino-D-arabinitol.
- 公益社団法人 日本薬学会の論文
著者
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HASHIMOTO Yuichi
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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Motoshima Kazunori
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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Ishikawa Minoru
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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Sugita Kazuyuki
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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Sugita Kazuyuki
Institute Of Molecular & Cellular Biosciences The University Of Tokyo
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Ishikawa Minoru
Institute Of Molecular & Cellular Biosciences The University Of Tokyo
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Ishikawa Minoru
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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