Conversion of Ca^<2+> Salt of an Organic Compound to Its Li^+ Salt to Simplify the Fast Atom Bombardment Mass Spectrum

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概要

• 論文の詳細を見る

• The FAB mass spectrum of the Ca^<2+> salt of RK-682 (1, MW 368), a potent protein tyrosine phosphatase inhibitor, shows a complex pattern due to Ca^<2+> adduct ions with multimers of 1 and their decomposition ions. Addition of LiCl greatly simplified the FAB mass spectrum, providing a prominent Li^+ adduction of 1 at m/z 381 [M+2Li-H]^+. The addition of LiCl also greatly simplified the FAB mass spectrum of calcium pantothenate. This approach may be generally useful for molecular weight determination of multivalent metal salts of organic compounds, or organic compounds that can form Li salts, by FAB mass spectrometry.

• 公益社団法人日本薬学会の論文
• 2003-11-01

著者

• Kagechika Hiroyuki

  Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat

• Kagechika Hiroyuki

  Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.

• KOBAYASHI Hisayoshi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• MORISAKI Naoko

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• Kobayashi H

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Hashimoto Y

  Univ. Tokyo Tokyo Jpn

• Nagasawa K

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Nagasawa Kazuo

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Morisaki N

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Morisaki Naoko

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• SODEOKA Mikiko

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• BABA Yoshiyasu

  Institute for Chemical Reaction Science, Tohoku University

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular And Cellular Biosciences The Universityv Of Tokyo

• Kobayashi Hisayoshi

  Institute Of Molecular And Cellular Biosciences University Of Tokyo

• Morisaki Naoko

  Institute Of Molecular And Cellular Bioscience The University Of Tokyo

• Sodeoka Mikiko

  Sagami Chemical Research Center

• Baba Y

  Institute For Chemical Reaction Science Tohoku University

• Kagechika H

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Nagasawa Kazuki

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Hashimoto Y

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Sodeoka Mikiko

  Institute for Chemical Reaction Science, Tohoku University

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