Asymmetric Synthesis of a 3-Acyltetronic Acid Derivative, RK-682, and Formation of Its Calcium Salt during Silica Gel Column Chromatography

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概要

• 論文の詳細を見る

• RK-682 was reported to be a potent protein tyrosine phosphatase inhibitor. We found that(R)-3-hexadecanoyl-5-hydroxymethyltetronic acid(1)was easily converted to its calcium salt during column chromatography on Silica gel 60, and this calcium salt was identical to RK-682 originally isolated from a natural source. Here we report details of the asymmetric synthesis of(R)-1 and its conversion to the calcium salt. Fast atom bombardment mass spectrometric(FAB-MS) analysis of the free and calcium salt forms of RK-682 is also reported.

• 公益社団法人日本薬学会の論文
• 2001-02-01

著者

• MORISAKI Naoko

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• Morisaki N

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Morisaki Naoko

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• SODEOKA Mikiko

  Institute of Molecular and Cellular Biosciences, University of Tokyo

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• BABA Yoshiyasu

  Institute for Chemical Reaction Science, Tohoku University

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Morisaki Naoko

  Institute Of Molecular And Cellular Bioscience The University Of Tokyo

• Sodeoka Mikiko

  Sagami Chemical Research Center

• SAMPE Ruriko

  Sagami Chemical Research Center

• KOJIMA Sachiko

  Sagami Chemical Research Center

• Baba Y

  Institute For Chemical Reaction Science Tohoku University

• Hashimoto Y

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Sodeoka Mikiko

  Institute for Chemical Reaction Science, Tohoku University

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