Development of Novel Chiral Urea Catalysts for the Hetero-Michael Reaction

スポンサーリンク

概要

• 論文の詳細を見る

• Chiral urea compounds 10a-g were synthesized as catalysts for conjugate addition of pyrrolidine (2) to γ-crotonolactone (3). In the presence of a catalytic amount of the chiral ureas, this hetero-Michael reaction was greatly accelerated. Asymmetric induction was observed with the catalysts 10e, 10f, and 10g.

• 公益社団法人日本薬学会の論文
• 2004-04-01

著者

• 棚谷 綾

  お茶の水女子大・理

• 棚谷 綾

  お茶の水女子大学大学院人間文化創成科学研究科理学専攻/先端融合部門

• HASHIMOTO Yuichi

  Institute of Molecular & Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Univ. Tokyo Tokyo Jpn

• Nagasawa K

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Nagasawa Kazuo

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Hashimoto Y

  Graduate School Of Pharmaceutical Sciences Kyushu University

• TANATANI Aya

  Faculty of Pharmaceutical Sciences, University of Tokyo

• TANATANI Aya

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular & Cellular Biosciences University Of Tokyo

• Hashimoto Yuichi

  Institute Of Molecular And Cellular Biosciences The Universityv Of Tokyo

• Tanatani A

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• SOHTOME Yoshihiro

  Institute of Molecular and Cellular Biosciences, The University of Tokyo

• Nagasawa Kazuki

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

• Hashimoto Y

  Institute Of Molecular & Cellular Biosciences The University Of Tokyo

• Sohtome Yoshihiro

  Institute Of Molecular And Cellular Biosciences The University Of Tokyo

関連論文

• 1-I-4 VDR活性をもつLCA誘導体の合成とVDR結合構造の解析(一般演題,日本ビタミン学会第62回大会発表要旨)
• Coordination of Divalent Metal Cation to Amide Group to Form Adduct Ion in FAB Mass Spectrometry: Implication of Zn^ in Enzymatic Hydrolysis of Amide Bond
• 1-IV-1 新規non-seco-ステロイド型ビタミンD誘導体の創製(ビタミン学の原点・栄養学への21世紀的回帰, 日本ビタミン学会第59回大会)
• 1.ビタミンDレセプターアンタゴニストDLAMの創製研究(第315回脂溶性ビタミン総合研究委員会研究発表要旨)
• Glycosylative Inactivation of Chalcomycin and Tylosin by a Clinically Isolated Nocardia asteroides Strain
• Structures of ADP-Ribosylated Rifampicin and Its Metabolite : Intermediates of Rifampicin-ribosylation by Mycobacterium smegmatis DSM43756
• N-メチル化アミド類のシス型優先性を利用した芳香族分子構築
• N-メチル化アミドのシス型優先性と芳香族分子構築
• Thermostability of Doubly Glycosylated Recombinant Lysozyme
• Expression and Characterization of Human Rheumatoid Factor Single-Chain FV
• Construction of the Single-Chain Fv from 196-14 Antibody toward Ovarian Cancer-Associated Antigen CA125
• Influence of Mutations of the N-Cap Residue, Gly4, on Stability and Structure of Hen Lysozyme
• Analysis of the Stabilization of Hen Lysozyme by Helix Macrodipole and Charged Side Chain Interaction
• Stabilization of Lysozyme by Introducing N-Glycosylation Signal Sequence
• A Mutation Study of Catalytic Residue Asp 52 in Hen Egg Lysozyme^1
• Correlation between the Differences in the Free Energy Change and conformational Energy in the Folded State of Hen Lysozymes with Gly-Pro and Pro-Gly Sequences Introduced to the Same Site
• Effect of Salt Concentration on the pK_a of Acidic Residues in Lysozyme
• EFFECT OF CYP2C POLYMORPHISMS ON THE PHARMACOKINETICS OF PHENYTOIN IN JAPANESE PATIENTS WITH EPILEPSY
• Population Pharmacokinetics of Phenytoin in Japanese Patients with Epilepsy : Analysis with a Dose-Dependent Clearance Model
• 2-II-21 新規非セコステロイド型VDRリガンドの構造展開と受容体結合様式の解析(一般研究発表,日本ビタミン学会第61回大会研究発表要旨)
• 4.カルボラン含有ビタミンD誘導体の創製とVDR結合様式(第320回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
• CHEMICAL BIOLOGY(8)核内受容体のケミカルバイオロジー研究
• 1P084 サリドマイド・アナログの抗インフルエンザウイルス活性(蛋白質-機能(反応機構,生物活性など),第48回日本生物物理学会年会)
• アミドの立体特性をいかした分子スイッチの構築 (平成19年度研究助成金受給者研究報告集)
• 環境応答型芳香族アミド化合物の構造変換と動的制御
• Enhancing Effect of Tumor Promoters, Phorbol Esters and Teleocidins on Nuclear Receptor-Mediated Transcription
• Identification of Protein Disulfide Isomerase as a Phorbol Ester-Binding Protein
• Photoaffinity Labeling of Tumor Promoter-Binding Protein (CN-TPBP) and Preparation of Affinity Sorbent Gels
• α-Glucosidase Inhibitors with a 4, 5, 6, 7-Tetrachlorophthalimide Skeleton Pendanted with a Cycloalkyl or Dicarba-closo-dodecaborane Group
• α-Glucosidase Inhibitors with a Phthalimide Skeleton : Stucture-Activity Relationship Study
• Modulators of Tumor Necrosis Factor α Production Bearing Dicarba-closo-dodecaborane as a Hydrophobic Pharmacophore
• Involvement of the CYP1A Subfamily in Stereoselective Metabolism of Carvedilol in β-Naphthoflavone-Treated Caco-2 Cells(Biopharmacy)
• 二人の恩師
• 核内受容体の構造制御と機能 (特集 ケミカルバイオロジーの新たな可能性)
• 核内受容体活性制御仮説に基づく特異的リガンドの創製研究
• 新規非seco-ステロイド型ビタミンD誘導体 : VDR,ARデュアルリガンドの創製(第317回脂溶性ビタミン総合研究委員会研究発表要旨)
• Novel Retinoidal Tropolone Derivatives. Bioisosteric Relationship of Tropolone Ring with Benzoic Acid Moiety in Retinoid Structure
• Retinoidal Pyrimidinecarboxylic Acids. Unexpected Diaza-Substituent Effects in Retinobenzoic Acids
• Retinoid X Receptor-Antagonistic Diazepinylbenzoic Acids
• NOVEL THIAZOLIDINEDIONE DERIVATIVES WITH RETINOID SYNERGISTIC ACTIVITY
• POTENT RETINOID SYNERGISTS WITH A DIPHENYLAMINE SKELETON
• Polyenylidine Thiazolidine Derivatives with Retinoidal Activities
• Photoaffinity Labeling of the Ligand-Interacting Helix of the Retinoic Acid Receptor Alpha
• Evaluation of Differentiation-Inducing Activity of Retinoids on Human Leukemia Cell Lines HL-60 and NB4
• NOVEL AROMATIC UREA DERIVATIVES WITH DNA-BINDING ABILITY
• DEIODOTRIFLUOROMETHYLATION OF ETHYL 3,3', 5-TRIIODOTHYROACETATE. DIVERGENT DERIVATIZATION BASED ON THE COMBINATORIAL CONCEPT
• Design and Synthesis of Phthalimide-Based Fluorescent Liver X Receptor Antagonists
• Structural Development of Benzhydrol-Type 1'-Acetoxychavicol Acetate (ACA) Analogs as Human Leukemia Cell-Growth Inhibitors Based on Quantitative Structure-Activity Relationship (QSAR) Analysis
• Structure-Based Design and Synthesis of Fluorescent PPARα/δ Co-agonist and Its Application as a Probe for Fluorescent Polarization Assay of PPARδ Ligands
• Fusarielin A as an Anti-angiogenic and Anti-proliferative Agent : Basic Biological Characterization
• Structural Development of Liver X Receptor (LXR) Antagonists Derived from Thalidomide-Related Glucosidase Inhibitors
• Development of Tubulin-Polymerization Inhibitors Based on the Thalidomide Skeleton
• Hydrolyzed Metabolites of Thalidomide : Synthesis and TNF-α Production-Inhibitory Activity
• Mono- and Dihydroxylated Metabolites of Thalidomide : Synthesis and TNF-α Production-Inhibitory Activity
• Effects of Immunomodulatory Derivatives of Thalidomide (IMiDs) and Their Analogs on Cell-Differentiation, Cyclooxygenase Activity and Angiogenesis
• Enhancement of All-trans Retinoic Acid-Induced HL-60 Cell Differentiation by Thalidomide and Its Metabolites(Communication to the Editor)
• N-Phenylphthalimide-Type Cyclooxygenase (COX) Inhibitors Derived from Thalidomide : Substituent Effects on Subtype Selectivity
• Thalidomide as a Nitric Oxide Synthase Inhibitor and Its Structural Development
• Conversion of Ca^ Salt of an Organic Compound to Its Li^+ Salt to Simplify the Fast Atom Bombardment Mass Spectrum
• Coordination of Sodium Cation to an Oxygen Function and Olefinic Double Bond to Form Molecular Adduct Ion in Fast Atom Bombardment Mass Spectrometry
• Separation of Phosphatidylinositol 4-Phosphate from a Mixture with Phosphatidylserine and Phosphatidylinositol by Sep-Pak C_ Cartridge
• Potent Homophthalimide-Type Inhibitors of B16F10/L5 Mouse Melanoma Cell Invasion
• OJ-003 Influences of CYP2D6 Genotype on Plasma Concentrations of Carvedilol : a Comparison with Metoprolol and Bisoprolol(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of
• Pharmacokinetics of R- and S-Carvedilol in Routinely Treated Japanese Patients with Heart Failure(Biopharmacy)
• Collisionally Activated Dissociation of 13-Membered Peptides, Ustiloxins, and Phomopsins
• Structural Identification of a Major Cytokinin in Coconut Milk as 14-O-{3-O-[β-D-Galactopyranosyl-(1→2)-α-D-galactopyranosyl-(1→3)-α-L-arabinofuranosyl]-4-O-(α-L-arabinofuranosyl)-β-D-galactopyranosyl}trans-zeatin Riboside
• Enhancement of Chemically-Induced HL-60 Cell Differentiation by 3,3′-Diindolylmethane Derivatives
• meso-DNAs with Homopurine Sequences : Analysis of Their Interaction with Natural DNAs
• Characterization of Poly-Leucine Substituted Analogues of the Human Surfactant Protein SP-C
• The Surface Properties of Chemically Synthesized Peptides Analogous to Human Pulmonary Surfactant Protein SP-C
• Synthesis and Anti-tubulin Activity of Ustiloxin D Derivatives
• Isolation and Structure of an Antimitotic Cyclic Peptide, Ustiloxin F: Chemical Interrelation with a Homologous Peptide, Ustiloxin B
• Interaction of Arenastatin A with Porcine Brain Tubulin
• INDUCER-SPECIFIC REGULATORS OF TUMOR NECROSIS FACTOR ALPHA PRODUCTION
• AUGMENTATION BY PHTHALIMIDES OF PHORBOL ESTER-INDUCED EXPRESSION OF TUMOR NECROSIS FACTOR ALPHA MESSAGE
• Location of Two Photoaffinity-Labeled Sites on the Ligand-Binding Domain of Retinoic Acid Receptor α
• Phenylphthalimides with Tumor Necrosis Factor Alpha Production-Enhancing Activity
• Development of Novel Chiral Urea Catalysts for the Hetero-Michael Reaction
• Specific Nonpeptide Inhibitors of Puromycin-Sensitive Aminopeptidase with a 2,4(1H,3H)-Quinazolinedione Skeleton
• Cyclooxygenase Inhibitors Derived from Thalidomide
• Asymmetric Synthesis of a 3-Acyltetronic Acid Derivative, RK-682, and Formation of Its Calcium Salt during Silica Gel Column Chromatography
• Anti-Androgenic Activity of Substituted Azo- and Azoxy-Benzene Derivatives
• Antiangiogenic Activity of Tumor Necrosis Factor-α Production Regulators Derived from Thalidomide
• Tumor Necrosis Factor-Alpha Production Enhancing Activity of Substituted 3'-Methylthalidomide : Influence of Substituents at the Phthaloyl Moiety on the Activity and Stereoselectivity
• Modification by Heme Oxygenase Inhibitor, Tin Protoporphyrin, of Cellular Differentiation of Human Myeloid Leukemia K562 Cell Line
• Nonlinear Mixed Effects Model Analysis of the Pharmacokinetics of Aripiprazole in Healthy Japanese Males(Biopharmacy)
• 環境応答型芳香族アミド化合物の構造変換と動的制御
• 有機化合物でつくる機能性らせん分子
• Nucleophilic asymmetric epoxidation catalyzed by cyclic guanidines
• Structure-Activity Relationship of Bis-Galloyl Derivatives Related to (-)-Epigallocatechin Gallate
• Identification of Binding Proteins of Fusarielin A as Actin and Tubulin
• Inhibition of Restriction Enzymes EcoRI, BamHI and HindIII by Phenethylphenylphthalimides Derived from Thalidomide
• Glycogen Phosphorylase a Inhibitors with a Phenethylphenylphthalimide Skeleton Derived from Thalidomide-Related α-Glucosidase Inhibitors and Liver X Receptor Antagonists
• P-415 Target Protein Identification of Batzelladine A and D
• 有機化合物でつくる機能性らせん分子(講座:らせんの織り成す不思議な世界3)
• ILVIII-3 STRUCTURAL DEVELOPMENT STUDIES OF NUCLEAR RECEPTOR LIGANDS(Drug Discovery and Developments)
• Thymidine Phosphorylase Inhibitors with a Homophthalimide Skeleton
• 4.非セコステロイド型ビタミンDの創製研究(第332回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
• 2-III-9 球状疎水性ファーマコフォアを有する非セコステロイド型VDRリガンドの構造活性相関(一般演題要旨,第65回大会講演要旨)
• Organosilicon Compounds as Adult T-Cell Leukemia Cell Proliferation Inhibitors

もっと見る 閉じる

スポンサーリンク