DEIODOTRIFLUOROMETHYLATION OF ETHYL 3,3', 5-TRIIODOTHYROACETATE. DIVERGENT DERIVATIZATION BASED ON THE COMBINATORIAL CONCEPT
スポンサーリンク
概要
- 論文の詳細を見る
A strategy for development of thyroid hormone analogs was examined based on the combinatorial concept. The reaction of ethyl 3,3'5-triiodothyroacetate (3b) with Cd/Br_2CF_2/CuBr followed by ester hydrolysis gave a mixture of more than ten products as detected by HPLC. The structures of the products in the bioactive fractions showed that the replacemnt of iodides with trifluoromethyl groups is an effective approach for obtaining thyromimetics.
- 公益社団法人日本薬学会の論文
- 1996-06-15
著者
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FUKASAWA Hiroshi
Graduate School of Pharmaceutical Sciences, The University of Tokyo
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Kagechika Hiroyuki
Graduate School Of Pharmaceutical Sciences The University Of Tokyo:research Foundation Itsuu Laborat
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Kagechika Hiroyuki
Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.
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Kagechika Hiroyuki
Faculty Of Pharmaceutical Sciences University Of Tokyo
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HASHIMOTO Yuichi
Institute of Molecular & Cellular Biosciences, The University of Tokyo
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SHUDO Koichi
Faculty of Pharmaceutical Sciences, The University of Tokyo
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Shudo Koichi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Shudo Koichi
Faculty Of Pharmaceutical Science Kyushu University
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FUKASAWA Hiroshi
Faculty of Pharmaceutical Sciences, University of Tokyo
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SAGI Kazuyuki
Faculty of Pharmaceutical Sciences, University of Tokyo
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Shudo K
Research Foundation Itsuu Laboratory
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Sagi Kazuyuki
Faculty Of Pharmaceutical Sciences University Of Tokyo
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Fukasawa Hiroshi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Fukasawa H
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
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Kagechika H
Tokyo Medical And Dental Univ. Tokyo Jpn
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Kagechika Hiroyuki
Faculty Of Pharmaceutical Sciences Graduate School Of Pharmaceutical Sciences The University Of Toky
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