C2_<BBe>1細胞におけるall-transおよび9-cisレチノイドの作用

概要

論文の詳細を見る
Retinoic acid (RA), which is an active metabolite of vitamin A, plays an important role in the development and differentiation. RA is synthesized from retinal by retinal dehydrogenases (RALDH). Recent studies reported RALDHs mRNA expression in the small intestine. However, it is unclear whether retinal and/or retinol is converted to RA in the enterocytes. In this study, we investigated whether the expression of RA-target genes and their promoter activity are affected by RA or its precursors, i.e., retinal or retinol in the human colonic adenocarcinoma cell line C2_<BBe>1. The mRNA levels of retinoic acid receptor β(RARβ) and cellular retinol-binding protein type II (CRBPII) and their promoter activity were elevated by RA and by retinol and retinal as well. These results suggest that RA is effectively converted from retinol or retinal in C2_<BBe>1 cell, and that the locally produced RA may induce vitamin A-target gene expression.
日本ビタミン学会の論文
2007-10-25