STERICAL PRORERTIES OF N, N'-DIMETHYLUREA MOIETY ENHANCE FORMATION OF TRIPLY HYDROGEN-BONDED COMPLEXES
スポンサーリンク
概要
- 論文の詳細を見る
N, N'-Dimethyl-N, N'-[2-(3-methylureido)pyrid-5-yl]urea (5) was designed and synthesized as a guanylyl-guanosine equivalent molecule. (E)-Perference of the urea bond of 5 enhanced the formation of highly associated complexes of 5 with bis(cytosyl)derivatives.
- 1996-02-15
著者
-
Kagechika Hiroyuki
Graduate School Of Biomedical Sci. Tokyo Medical And Dental Univ.
-
Kagechika Hiroyuki
Faculty Of Pharmaceutical Sciences University Of Tokyo
-
YAMAGUCHI KENTARO
Chemical Analytical Center, Chiba University
-
SHUDO Koichi
Faculty of Pharmaceutical Sciences, The University of Tokyo
-
Yamaguchi K
Analysis Center Chiba University
-
Shudo Koichi
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
-
Shudo Koichi
Faculty Of Pharmaceutical Science Kyushu University
-
AZUMAYA Isao
Faculty of Pharmaceutical Sciences, University of Tokyo
-
Shudo K
Research Foundation Itsuu Laboratory
-
Yamaguchi Kentaro
Chemical Analysis Center Chiba University
-
Azumaya Isao
Faculty Of Pharmaceutical Sciences University Of Tokyo
-
Azumaya I
Kitasato Univ. Tokyo Jpn
-
Azumaya Isao
Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University
-
Kagechika H
Tokyo Medical And Dental Univ. Tokyo Jpn
-
Kagechika Hiroyuki
Faculty Of Pharmaceutical Sciences Graduate School Of Pharmaceutical Sciences The University Of Toky
-
Yamaguchi Kentaro
Chemical Analysis Center Chiba Univ. Chiba 263-8522 Jpn
関連論文
- 1-I-4 VDR活性をもつLCA誘導体の合成とVDR結合構造の解析(一般演題,日本ビタミン学会第62回大会発表要旨)
- 環境応答性を有する新規クマリン誘導体
- Coordination of Divalent Metal Cation to Amide Group to Form Adduct Ion in FAB Mass Spectrometry: Implication of Zn^ in Enzymatic Hydrolysis of Amide Bond
- C2_1細胞におけるall-transおよび9-cisレチノイドの作用
- 1-IV-1 新規non-seco-ステロイド型ビタミンD誘導体の創製(ビタミン学の原点・栄養学への21世紀的回帰, 日本ビタミン学会第59回大会)
- レチノイドによる自己免疫疾患の治療
- 6.合成レチノイドAm80の医薬品化と今後の創薬展開(脂溶性ビタミン総合研究委員会第308回会議研究発表要旨)
- 405 合成レチノイドTZ325の自己免疫疾患に及ぼす影響について
- 325 合成レチノイド誘導体Tp-80の実験的自己免疫疾患に及ぼす影響について
- パキマ酸によるPPARγの特異的活性化と脂肪細胞の分化誘導作用
- 2-I-2 α-Tocopherol誘導体(8-HM)のラットにおけるビタミンE活性 : 第49回大会一般研究発表要旨
- レチノイド アンタゴニスト
- SYNERGISTS FOR RETINOID IN CELLULAR DIFFERENTIATION OF HUMAN PROMYELOCYTIC LEUKEMIA CELLS HL-60
- レチノイドの作用の分離とレチノイドアンタゴニスト レセプター選択的化合物の試薬・医薬への開発
- SPECIFIC OXIDATION OF RETINOIC ACID TO 4-OXO-RETINOIC ACID IN DILUTED ACID SOLUTIONS
- 4.活性ビタミンE仮説 : ビタミンE誘導体の合成と活性 : 脂溶性ビタミン総合研究委員会 第262回会議研究発表要旨
- Retinoidal Dienamides and Related Aromatic Amides. Replacement of the 9-Ene Structure of Retinoic Acid with a trans- or cis-Amide Group
- Synthesis and Biological Activity of Carboxyphenylquinolines and Related Compounds as New Potent Retinoids. Retinobenzoic Acids. VII
- Determination of Endogenous Levels of Retinoic Acid Isomers in Type II Diabetes Mellitus Patients. Possible Correlation with HbAlc Values(Analytical Biochemistry)
- Transvalencin A, a Thiazolidine Zinc Complex Antibiotic Produced by a Clinical Isolate of Nocardia transvalensis : II. Structure Elucidation
- Isolation and Structural Characterization of Siderophores, Madurastatins, Produced by a Pathogenic Actinomadura madurae
- Asterobactin, a New Siderophore Group Antibiotic from Nocardia asteoides
- ベンズアニリド及びN-メチルベンズアニリドの立体化学
- N-メチル化アミド類のシス型優先性を利用した芳香族分子構築
- 芳香族分子建築学--シス形アミドのおりなす立体化学の世界
- 2-II-21 新規非セコステロイド型VDRリガンドの構造展開と受容体結合様式の解析(一般研究発表,日本ビタミン学会第61回大会研究発表要旨)
- 蛍光物質の会合現象の制御による蛍光センサー開発
- 4.カルボラン含有ビタミンD誘導体の創製とVDR結合様式(第320回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
- 新規甲状腺ホルモン受容体アンタゴニスト--バセドウ病などの甲状腺機能亢進症の治療に好適
- 新規フェノール誘導体による代謝制御
- カルボランの特性をいかしたアンドロゲン受容体リガンドの創製
- ライブラリー構築をもとにした蛍光センサーの開発
- CHEMICAL BIOLOGY(8)核内受容体のケミカルバイオロジー研究
- Grinding-Induced Equimolar Complex Formation between Thiourea and Ethenzamide
- Novel Channel Structure of Bile Acid-Guest Inclusion Complex Formed between Ursodeoxycholic Acid and Phenanthrene
- Crystal Structure of the Alcoholates and the Ansolvate of PNU-97018, an Angiotensin II Receptor Antagonist
- Collision-Induced Dissociation Actualized the H^+-Promoted Reaction as Observed in Vitro ; Harman Formation from β-Carboline-Type Monoterpenoid Glucoindole Alkaloids
- Structure Determination of Ribosylated Rifampicin and Its Derivative:New Inactivated Metabolites of Rifampicin by Mycobacterial Strains
- Isolation and Structures of an Antifungal Antibiotic, Fusarielin A, and Related Compounds Produced by a Fusarium sp.
- Application of Difference NOE-pumping NMR Technique and Cold-Spray Ionization Mass Spectrometry to Identify a Ligand Binding with a Protein Receptor
- Facile Characterization of Polymer-Supported Reagents Using Cross Polarization Magic Angle Spinning Method in Solid State ^C-NMR
- Segment Identification of a Ligand Binding with a Protein Receptor Using Multidimensional T_1ρ-, Diffusion-Filtered and Diffusion-Ordered NOESY Experiments
- A New Broad Band Probe Covering from ^P-to^Cl-Nuclear Magnetic Resonance
- PFG J-HMBC 2D NMR Spectroscopic Observation of the Natural Abundance ^1H-^N Long-Range Coupling
- (Cis)-PREFERENCE OF N, N'-DIMETHYL-N, N'-DIPHENYLGUANIDINE AND THE GUANIDINIUM SALT. CONSTRUCTION OF WATER-SOLUBLE AROMATIC LAYERED STRUCTURE
- STERICAL PRORERTIES OF N, N'-DIMETHYLUREA MOIETY ENHANCE FORMATION OF TRIPLY HYDROGEN-BONDED COMPLEXES
- Identification of Protein Disulfide Isomerase as a Phorbol Ester-Binding Protein
- Functionalization of Polymethylcarboranes. Preparation and Reactivity of 2,3,4,5,6,7,8,9,10,11-Decamethyl-1,12-dicarba-closo-dodecaborane(12)-1-carboxylic Acid
- Dicarba-closo-dodecaboranes as a Pharmacophore. Novel Potent Retinoidal Agonists
- Dicarba-closo-dodecaboranes as a Pharmacophore. Retinoidal Antagonists and Potential Agonists
- Brasiliquinones A, B and C, New Benz[a]anthraquinone Antibiotics from Nocardia brasiliensis I. Producing Strain, Isolation and Biological Activities of the Antibiotics
- α-Glucosidase Inhibitors with a 4, 5, 6, 7-Tetrachlorophthalimide Skeleton Pendanted with a Cycloalkyl or Dicarba-closo-dodecaborane Group
- Latent Enamine Functionality of 5-Methyl-2,3-dihydropyrazines
- Novel Retinoidal Tropolone Derivatives. Bioisosteric Relationship of Tropolone Ring with Benzoic Acid Moiety in Retinoid Structure
- Retinoidal Pyrimidinecarboxylic Acids. Unexpected Diaza-Substituent Effects in Retinobenzoic Acids
- Retinoid X Receptor-Antagonistic Diazepinylbenzoic Acids
- Thiazolidinediones with Thyroid Hormone Receptor Agonistic Activity
- NOVEL THIAZOLIDINEDIONE DERIVATIVES WITH RETINOID SYNERGISTIC ACTIVITY
- POTENT RETINOID SYNERGISTS WITH A DIPHENYLAMINE SKELETON
- Polyenylidine Thiazolidine Derivatives with Retinoidal Activities
- Photoaffinity Labeling of the Ligand-Interacting Helix of the Retinoic Acid Receptor Alpha
- Evaluation of Differentiation-Inducing Activity of Retinoids on Human Leukemia Cell Lines HL-60 and NB4
- NOVEL AROMATIC UREA DERIVATIVES WITH DNA-BINDING ABILITY
- DEIODOTRIFLUOROMETHYLATION OF ETHYL 3,3', 5-TRIIODOTHYROACETATE. DIVERGENT DERIVATIZATION BASED ON THE COMBINATORIAL CONCEPT
- New-Type Inducers of Differentiation of HL-60 Leukemia Cells Suppress c-myc Expression(Medeicinal Chemistry,Chemical)
- Crystal Structures and Physical Properties of Tris-(2, 3-epoxypropyl)-isocyanate
- Antitumor Activity of Brasilicardin A, a Novel Terpenoid Antibiotic from Nocardia brasiliensis
- A New Antifungal Macrolide Component, Brasilinolide B, Produced by Nocardia brasiliensis
- Production of Erythromycin E by Pathogenic Nocardia brasiliensis
- Brasilicardin A, a New Terpenoid Antibiotic from Pathogenic Nocardia brasilienesis: Fermentation, Isolation, and Biological Activity
- Brasilicardin A ; a New Terpenoid Antibiotic Produced by Nocardia brasiliensis
- Brasilinolide A, a New Macrolide Antibiotic Produced by Nocardia brasiliensis: Producing Strain, Isolation and Biological Activity
- Different Rifampicin Inactivation Mechanisms in Nocardia and Related Taxa
- A Synthetic Retinoid Am80 (Tamibarotene) Rescues the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm(Communications to the Editor)
- Fusarielin A as an Anti-angiogenic and Anti-proliferative Agent : Basic Biological Characterization
- Development of Tubulin-Polymerization Inhibitors Based on the Thalidomide Skeleton
- Mono- and Dihydroxylated Metabolites of Thalidomide : Synthesis and TNF-α Production-Inhibitory Activity
- Effects of Immunomodulatory Derivatives of Thalidomide (IMiDs) and Their Analogs on Cell-Differentiation, Cyclooxygenase Activity and Angiogenesis
- Enhancement of All-trans Retinoic Acid-Induced HL-60 Cell Differentiation by Thalidomide and Its Metabolites(Communication to the Editor)
- Conversion of Ca^ Salt of an Organic Compound to Its Li^+ Salt to Simplify the Fast Atom Bombardment Mass Spectrum
- Coordination of Sodium Cation to an Oxygen Function and Olefinic Double Bond to Form Molecular Adduct Ion in Fast Atom Bombardment Mass Spectrometry
- Potent Homophthalimide-Type Inhibitors of B16F10/L5 Mouse Melanoma Cell Invasion
- Anicequol, a Novel Inhibitor for Anchorage-independent Growth of Tumor Cells from Penicillium aurantiogriseum Dierckx TP-F0213
- 3.カルホラン含有レチノイト(第300回脂溶性ビタミン総合研究委員会研究発表要旨)
- Collisionally Activated Dissociation of 13-Membered Peptides, Ustiloxins, and Phomopsins
- Structural Identification of a Major Cytokinin in Coconut Milk as 14-O-{3-O-[β-D-Galactopyranosyl-(1→2)-α-D-galactopyranosyl-(1→3)-α-L-arabinofuranosyl]-4-O-(α-L-arabinofuranosyl)-β-D-galactopyranosyl}trans-zeatin Riboside
- Am80, a Novel Synthetic RAR Agonist and a Modulator of KLF5, Prevents Cardiac Remodeling in Vivo
- レチノイド (分子レベルの栄養学)
- Specific Nonpeptide Inhibitors of Puromycin-Sensitive Aminopeptidase with a 2,4(1H,3H)-Quinazolinedione Skeleton
- Cyclooxygenase Inhibitors Derived from Thalidomide
- 5. レチノイドX受容体リガンドの構造と機能
- 環境応答型芳香族アミド化合物の構造変換と動的制御
- 環境応答型芳香族アミドの立体特性
- レチノイド同効物質及び拮抗物質の医薬化学
- 2-II-17 ケイ素およびゲルマニウムを持つレチノチドX受容体(RXR)リガンドの開発(一般演題要旨,日本ビタミン学会第63回大会講演要旨)
- 有機化合物でつくる機能性らせん分子(講座:らせんの織り成す不思議な世界3)
- Retinoic acids exert direct effects on T cells to suppress T_h1 development and enhance T_h2 development via retinoic acid receptors
- 4.非セコステロイド型ビタミンDの創製研究(第332回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
- 2-III-9 球状疎水性ファーマコフォアを有する非セコステロイド型VDRリガンドの構造活性相関(一般演題要旨,第65回大会講演要旨)
- シンポジウム「ビタミン誘導体の臨床応用」開催について(「ビタミン誘導体の臨床応用」(第64回大会シンポジウム))