Grinding-Induced Equimolar Complex Formation between Thiourea and Ethenzamide

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概要

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• We prepared and characterized a grinding-induced equimolar complex of thiourea with ethenzamide. When thiourea and ethenzamide were co-ground at a molar ratio of 3 : 1, new powder X-ray diffraction (PXRD) peaks were observed in addition to PXRD peaks of thiourea crystals. The optimum stoichiometry of the new structure was confirmed as 1 : 1 mol/mol. Effect of grinding time on the thiourea-ethenzamide equimolar complex formation was investigated by using PXRD, differential scanning calorimetry and Fourier transform infrared spectroscopy. The equimolar crystal structure was confirmed by X-ray diffraction measurements of the single crystal which was recrystallized from ethanol. It was found that the intermolecular hydrogen bond formations between thiourea and ethenzamide molecules contributed to the equimolar complex formation. The complex formation was not observed in the cases where benzamide, salicylamide or 3-ethoxybenzamide was co-ground with thiourea. 2-Alcoxyl benzamide structures should be required for the grinding-induced equimolar complex formation with thiourea.

• 社団法人日本薬学会の論文
• 2004-05-01

著者

• Yamamoto K

  Graduate School Of Pharmaceutical Sciences Chiba University

• YAMAGUCHI KENTARO

  Chemical Analytical Center, Chiba University

• Moribe Kunikazu

  Graduate School of Pharmaceutical Sciences, Chiba University

• Yamamoto Keiji

  Graduate School of Pharmaceutical Sciences, Chiba University

• Yamaguchi K

  Tokushima Bunri Univ. Sanuki‐city Jpn

• Tsuchiya Masami

  Graduate School Of Pharmaceutical Sciences Chiba University

• TOZUKA Yuichi

  Graduate School of Pharmaceutical Sciences, Chiba University

• OGUCHI Toshio

  Department of Pharmacy, University Hospital, Faculty of Medicine, University of Yamanashi

• Yuichi Tozuka

  Laboratory Of Pharmaceutical Engineering Gifn Pharmaceutical University

• Oguchi T

  Department Of Pharmacy University Hospital University Of Yamanashi

• Oguchi Toshio

  Department Of Pharmacy University Hospital University Of Yamanashi

• Oguchi Toshio

  Faculty Of Pharmaceutical Sciences Chiba University

• Moribe Kunikazu

  Faculty Of Pharmaceutical Sciences Teikyo University

• Moribe Kunikazu

  Graduate School Of Pharmaceutical Sciences Chiba University

• Yamaguchi Kentaro

  Chemical Analysis Center Chiba University

• Yamaguchi Kentaro

  Fac. Of Pharmaceutical Sciences Tokushima Bunri Univ. Kagawa Campus

• Yamamoto Keiji

  Graduate School Of Pharmaceutical Sciences Chiba University

• Yamaguchi Kentaro

  Chemical Analysis Center Chiba Univ. Chiba 263-8522 Jpn

• Moribe Kunikazu

  Graduate School Of Pharmaceutical Sciences Chiba Univ.

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