Comparison of Crystallinity of Cefditoren Pivoxil Determined by X-Ray, Differential Scanning Calorimetry and Microcalorimetry

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概要

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• The heat of crystallization and heat of solution of cefditoren pivoxil of different crystallinities were determined by differential scanning calorimetry and isothermal microcalorimetry, respectively. The heat of crystallization and heat of solution of ground cefditoren pivoxil showed good linear correlation with the degree of crystallinity determined by Ruland's method by powder X-ray diffractogram. The changes in crystallinity of amorphous cefditoren pivoxil by adsorption of alcohol vapor could be evaluated for small amounts of sample by use of heat of crystallization. Since the apparent dissolution rate of cefditoren pivoxil of various crystallinities correlated with the heat of solution, microcalorimetry was found to be useful for prediction of dissolution behavior.

• 公益社団法人日本薬学会の論文
• 1999-11-15

著者

• Yamamoto K

  Graduate School Of Pharmaceutical Sciences Chiba University

• Ono M

  Tokushima Bunri Univ. Tokushima Jpn

• Yuichi Tozuka

  Laboratory Of Pharmaceutical Engineering Gifn Pharmaceutical University

• OGUCHI Toshio

  Faculty of Pharmaceutical Sciences, Chiba University

• YAMAMOTO Keiji

  Faculty of Pharmaceutical Sciences, Chiba University

• TOZUKA Yuichi

  Faculty of Pharmaceutical Sciences, Chiba University

• OHTA MASATO

  Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd.

• Oguchi T

  Department Of Pharmacy University Hospital University Of Yamanashi

• Ohta Masato

  Pharmaceutical Research Center Meiji Seika Kaisha Ltd.

• Oguchi Toshio

  Faculty Of Pharmaceutical Sciences Chiba University

• Ohta Miyako

  Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences

• Yamamoto Keiji

  Faculty Of Pharmaceutical Sciences Chiba University

• Yamamoto Keiji

  Faculty Of Materials Science And Engineering Science University Of Tokyo In Yamaguchi

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