Effects of Added Lower Alcohols on Solubilized Tocopherol Acetate Sorption to Polyethylene Film in Aqueous Solution

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概要

• 論文の詳細を見る

• The effects of added lower alcohols on the sorption of tocopherol acetate (VEA) to polyethylene film were studied in an aqueous solution with polyoxyethylene cetyl ether used as a solubilizer. The sorption rate of solubilized VEA increased in inverse proportion to the dielectric constant of added lower alcohols. The increasing concentrations of lower alcohols resulted in turbidity of the VEA-surfactant system, i.e., a reduction of the VEA solubilizing ability of the surfactant, followed by transparentization. An increase in ethanol concentration enhanced the sorption rate of solubilized VEA followed by a rate decrease. It also caused greater solubility of VEA in the absence of the surfactant, increasing the polarity of the surfactant micellar interior and causing disintegration of the micelles. Lower alcohols lessen the polarity of the solution in inverse proportion to the dielectric constant of the alcohols. Consequently, the alcohols may be responsible for weakening the hydrophobic binding between hydrophobic VEA and the hydrocarbon chain in the surfactant due to an increased affinity of VEA and the surfactant molecules for the bulk phase. We thus conclude that the sorption of solubilized VEA to polyethylene film is accelerated by thermodynamic labilization of VEA, but an increase in the VEA solubility in an aqueous-alcohol phase contributes to a decrease in the sorption rate.

• 公益社団法人日本薬学会の論文
• 1996-01-15

著者

• YAMAMOTO Keiji

  Faculty of Pharmaceutical Sciences, Chiba University

• SATO Hiroshi

  Central Research Laboratory, Hitachi Ltd.

• SATO Hiromi

  Tohoku College of Pharmacy

• Sato H

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• Takahashi H

  Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Seki M

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• FUKAHORI Masahiro

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• TAKAHASHI Hiroaki

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• SEKI Masako

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• KAKINUMA Keiko

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• UCHINO Yasuhide

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• Kakinuma K

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Uchino Yasuhide

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Fukahori Masahiro

  Central Research Laboratories Zeria Pharmaceutical Co.ltd.

• Yamamoto Keiji

  Faculty Of Pharmaceutical Sciences Chiba University

• Yamamoto Keiji

  Faculty Of Materials Science And Engineering Science University Of Tokyo In Yamaguchi

• Takahashi Hiroyasu

  Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

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