Expression of Matrix Metralloproteinase-11 (Stromelysin-3) and TIMP-1 Genes in the Placenta and the Uterus during Estrous Cycles and Gestation in the Mouse
スポンサーリンク
概要
- 論文の詳細を見る
Changes in MMP-11 (stromelysin-3) and TIMP-1 gene expression in the uterus and the placenta of the mouse during different reproductive stages were examined by quantitative RT-PCR. MMP-11 expression rose steeply from baseline levels in early estrus, and reached a peak at estrus, and then declined rapidly on diestrus. During pregnancy, high levels of MMP-11 mRNA were detected in the uterus on Days 1 and 19 of gestation, while it was minimal on Day 7. A reciprocal relationship was found between MMP-11 and TIMP-1 expression both in the uterus and the placenta. These observations suggest a role for MMP-11 in the remodeling of uterine extracellular matrix during the estrous cycle and the pregnancy.
- 日本繁殖生物学会の論文
著者
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SATO Hiroshi
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
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TANAKA Satoshi
Laboratory of Cellular Biochemistry, Animal Resource Sciences/Veterinary Medical Sciences, The Unive
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SEIKI Motoharu
Department of Cancer Cell Research, Institute of Medical Science, University of Tokyo
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TOJO Hideaki
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tok
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Tanaka S
Univ. Tokyo Tokyo Jpn
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Tachi Chikashi
Laboratory of Applied Genetics, Department of Animal Resource Science, School of Agriculture and Lif
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Sato H
Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.
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Hara Takahito
Laboratory of Applied Genetics, Institute of Animal Resource Sciences, School of Agriculture and Lif
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