Synthesis of the Side Chain of a Novel Carbapenem via Iodine-Mediated Oxidative Cyclization of (1R)-N-(1-Aryl-3-butenyl)acetamide

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概要

• 論文の詳細を見る

• A (2R, 4S)-trans-disubstituted pyrrolidine ring system was constructed by emloying iodine-mediated oxidative cyclization of (1R)-N-[1-(4-bromophenyl)-3-butenyl]acetamide 3 as a key step. The resulting diastereomeric mixture of (2R)-2-aryl-4-acetoxypyrrolidine 4 was stereoselectively converted to the side-chain of a novel ultrabroad-spectrum carbapenem 1,via (2R, 4R)-2-aryl-4-hydroxypyrrolidine 7.

• 公益社団法人日本薬学会の論文
• 2002-03-01

著者

• SATO Hiromi

  Tohoku College of Pharmacy

• HASHIHAYATA Takashi

  Banyu Tsukuba Research Institute

• SAKOH Hiroki

  Banyu Tsukuba Research Institute

• GOTO Yasuhiro

  Banyu Tsukuba Research Institute

• YAMADA Koji

  Banyu Tsukuba Research Institute

• MORISHIMA Hajime

  Banyu Tsukuba Research Institute

• Sato H

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• GOTO Yuki

  Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto

• Yamada K

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Goto Yuki

  Faculty Of Environmental And Symbiotic Sciences Prefectural University Of Kumamoto

• Yamada Katsuya

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• Sakoh H

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• HASHIHAYATA Takashi

  Center for Basic Research, The Kitasato Institute (TCI)

• Morishima H

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• Hashizume T

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• Hashihayata T

  Center For Basic Research The Kitasato Institute (tci)

• Sakoh Hiroaki

  Banyu tsukuba Research Institute

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