Practical Synthesis of a 1β-Methylcarbapenem, J-111, 225, Using 4-Mercapto-2-[4-(N-methylaminomethyl)phenyl]pyrrolidine as a Precursor

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概要

• 論文の詳細を見る

• An effective and practical procedure for the synthesis of J-111, 225(1), a new 1β-methylcarbapenem, was developed using 4-mercapto-2-[4-(N-methylaminomethyl)phenyl]pyrrolidine(2a)as a precursor. The coupling reaction of 2a with p-nitrobenzyl(PNB)-protected 1β-methylcarbapenem enolphosphate 3a and successive removal of PNB group afforded J-111, 225(1)in significantly increased yield compared to the ordinary procedure using a C-2 side-chain thiol with amino-protective groups.

• 公益社団法人日本薬学会の論文
• 2001-04-01

著者

• SATO Hiromi

  Tohoku College of Pharmacy

• SAKURABA Shunji

  Banyu Tsukuba Research Institute

• IMAMURA Hideaki

  Banyu Tsukuba Research Institute

• SUGIMOTO Yuichi

  Banyu Tsukuba Research Institute

• YAMADA Koji

  Banyu Tsukuba Research Institute

• MORISHIMA Hajime

  Banyu Tsukuba Research Institute

• Sato H

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• SHIMIZU Aya

  Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.

• SATO Hiroki

  Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd.

• Sugimoto Yoshikazu

  Hanno Research Center Taiho Pharmaceutical Co. Ltd.

• Yamada K

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Shimizu A

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• Yamada Katsuya

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• Sakuraba S

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• Sugimoto Yuichi

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• Sakoh H

  Department Of Applied Chemistry Faculty Of Science Science University Of Tokyo

• Morishima H

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• Imamura H

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

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