Aggregate Formation of p-Hydroxybenzoic Acid Esters in Aqueous Solution

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概要

• 論文の詳細を見る

• The aggregate formation of p-hydroxybenzoic acid esters (parabens) in aqueous solutions was studied by ultrafiltration and light scattering. The permeability of parabens in aqueous solution passing through an ultrafiltration membrane decreased with an increase in carbon number in the alkyl group from methyl- to butyl-paraben. Dissociation of the phenolic hydroxyl group and the addition of ethanol made possible the free passage of butyl-paraben through the membrane. An increase in the concentration of butyl-paraben was responsible for the steep rise in light scattering intensity plots. Undissociated molecules of parabens in aqueous solution are thus shown to form aggregates by hydrophobic intermolecular force. The membrane permeability of butyl-paraben decreased and increased with concentration and the cutoff molecular weights of the membranes, respectively. Plots of surface tension against concentration of butyl-paraben showed a linear decrease but no inflection point. Paraben molecules possessing long alkyl chains may thus be concluded to form non-micellar type aggregates in aqueous solution, which differ from the clear-cut aggregate formation of conventional surfactants.

• 公益社団法人日本薬学会の論文
• 1996-01-15

著者

• SATO Hiroshi

  Central Research Laboratory, Hitachi Ltd.

• SATO Hiromi

  Tohoku College of Pharmacy

• Sato H

  Banyu Tsukuba Research Institute Banyu Pharmaceutical Co. Ltd.

• YOTSUYANAGI Toshihisa

  Faculty of Pharmaceutical Sciences, Nagoya City University

• Takahashi H

  Institute Of Pharmacognosy Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• FUKAHORI Masahiro

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• TAKATSUJI Yasuo

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• TAKAHASHI Hiroaki

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• YAMAKITA Takahiro

  Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.,

• Takatsuji Yasuo

  Central Research Laboratories Zeria Pharmaceutical Co.ltd.

• Fukahori Masahiro

  Central Research Laboratories Zeria Pharmaceutical Co.ltd.

• Yamakita T

  Central Research Laboratories Zeria Pharmaceutical Co. Ltd.

• Yotsuyanagi T

  Nagoya City Univ. Nagoya Jpn

• Yotsuyanagi Toshihisa

  Faculty Of Pharmaceutical Science Nagoya City University

• Takahashi Hiroyasu

  Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

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