Disulfide Bond Cleavage of Human Fibrinogen by cis-Diamminedichloroplatinum (II)
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概要
- 論文の詳細を見る
Disulfide bridges in fibrinogen (Fbg) were cleaved by cis-diamminedichloroplatinum (II) (cis-DDP). Incubation with 120 molar excess of cis-DDP at pH 7.4 and 37℃ in the presence of EDTA resulted in cleavage of seven disulfide bridges out of 29. In the presence of calcium, however, the number of cleavages were reduced to four. The result indicates that calcium, which has three high affinity sites on Fbg, protects disulfide bridges from the rupture. Thrombin clottability was examined by turbidity measurement. The cis-DDP treated Fbg was shown to give a decreased fiber thickness. As the cleavage proceeded, the clotting ability of Fbg decreased.
- 公益社団法人日本薬学会の論文
著者
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Ikeda Katsumi
Faculty Of Pharmaceutical Sciences Okayama University
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Ohta N
Department Of Molecular Parasitology Nagoya City University Graduate School Of Medicine Sciences
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OHTA Naoko
Faculty of Pharmaceutical Sciences, Nagoya City University
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YOTSUYANAGI Toshihisa
Faculty of Pharmaceutical Sciences, Nagoya City University
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IKEDA Ken
Faculty of Pharmaceutical Sciences, Nagoya City University
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Ohta Naoko
Faculty Of Pharmaceutical Sciences Nagoya City University
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Ikeda K
Life Science Laboratories Central Research Laboratories Ajinomoto Co. Inc.:pharmaceuticals Research
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Yotsuyanagi T
Nagoya City Univ. Nagoya Jpn
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Yotsuyanagi Toshihisa
Faculty Of Pharmaceutical Science Nagoya City University
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Ikeda Ken
Faculty Of Pharmaceutical Science Nagoya City University Medical School
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