Formation of Reactive Oxygen Intermediates Might be Involved in the Trypanocidal Activity of Gallic Acid

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概要

• 論文の詳細を見る

• We investigated the mechanism of the trypanocidal activity of gallic acid (GA). GA-induced trypanocidal activity was significantly reduced by pretreatment with superoxide dismutase (SOD) and/or catalase. The ESR technique with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) as a spin trapping agent revealed that a DMPO-OH adduct was detected in culture medium containing GA. The intensity of ESR signals of the DMPO-OH adduct was increased in a time dependent manner. SOD also inhibited the formation of GA-induced DMPO-OH adducts. Furthermore, GA enhanced DNA single-strand breaks induced by Fenton reagent. These results suggest the possibility that GA acts as a pro-oxidant for trypanocidal activity.

• 社団法人日本薬学会の論文
• 1998-06-15

著者

• Inoue Makoto

  Department of Pediatrics, Shimane Medical University

• Inoue M

  Lab. Of Medicinal Resources School Of Pharmacy Aichi Gakuin Univ.

• OHTA Nobuo

  Department of Otolaryngology, Yamagata University School of Medicine

• Ohta N

  Section Of Environmental Parasitology Tokyo Medical And Dental University

• Ohta Nobuo

  名古屋市立大学 医学研究科 宿主寄生体関係学

• Ogihara Yukio

  Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University

• Ogihara Yukio

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nogoya City University

• Ogihara Yukio

  Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive

• Ogihara Yukio

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• Inoue M

  Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University

• YABU Yoshisada

  Department of Molecular Parasitology, Nagoya City University, Graduate School of Medical Sciences

• NOSE Mitsuhiko

  Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University

• NOSE Mitsuhiko

  Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City Uni

• KOIDE Tatsuo

  Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City Uni

• MORIKAWA Kyoko

  Department of Pharmacognosy and Plant Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City Uni

• Ohta N

  Department Of Molecular Parasitology Nagoya City University Graduate School Of Medicine Sciences

• Ohta Nobuo

  Department Of Medical Zoology Nagoya City University Medical School

• Yabu Y

  Department Of Molecular Parasitology Nagoya City University Graduate School Of Medicine Sciences

• Ohta Nobuo

  Section Of Environmental Parasitology Tokyo Medical And Dental University

• Koide T

  Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University

• Yabu Yoshisada

  Department Of Molecular Parasitology Nagoya City University Graduate School Of Medicine Sciences

• Morikawa K

  Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive

• Morikawa Kyoko

  Department Of Obstetrics And Gynecology St. Marianna University School Of Medicine Yokohama City Sei

• Nose M

  Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University

• Ohta Nobuo

  Department Of Ent School Of Medicine Yamagata University

• Komiyama T

  Department Of Biochemistry Faculty Of Pharmaceutical Sciences Niigata University Of Pharmacy And App

• Inoue Makoto

  Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University

• Yabu Yoshisada

  Department Of Molecular Parasitology Nagoya City University Graduate School Of Medical Sciences

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