Repression of Acyl-CoA : Cholesterol Acyltransferase by a Traditional Herbal Medicine (Kampo Meidcine), Ogi-Keishi-Gomotsu-To-Ka-Kojin
スポンサーリンク
概要
- 論文の詳細を見る
Ogi-Keishi-Gomotsu-To-Ka-Kojin (OKGK) is a traditional herbal medicine (Kampo medicine) which has been found to ameliorate hypercholesterolemia and hypertriglyceridemia in rats and rabbits. In the present study, the effect of OKGK on acyl-CoA : cholesterol acyltransferase (ACAT) was studied in order to elucidate the mechanism of its antihypercholesterolemic action. Oral administration of OKGK to rats fed a cholesterol-enriched diet for 4 weeks markedly repressed the increase in ACAT activity in the small intestine. In contrast, OKGK did not influence hepatic ACAT activity. These results indicate that OKGK selectively inhibits ACAT activity in the small intestine relative to that in the liver, resulting in a reduction of cholesterol absorption, followed by a decrease in serum cholesterol.
- 公益社団法人日本薬学会の論文
- 1999-09-15
著者
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Inoue Makoto
Department of Pediatrics, Shimane Medical University
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Inoue M
Lab. Of Medicinal Resources School Of Pharmacy Aichi Gakuin Univ.
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Wu Chun
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagoya City University
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Wu Chun
名古屋市立大学 薬 生薬
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Ogihara Yukio
Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nogoya City University
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Ogihara Yukio
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Inoue M
Laboratory Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City University
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Ogihara Y
Department Of Pharmacognosy And Plant Chemistry Faculty Of Pharmaceutical Sciences Nagoya City Unive
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Wu Chun
Department Of Electrical Engineering National Sun Yat-sen University
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Inoue Makoto
Department Of Biological Chemistry Faculty Of Pharmaceutical Sciences Nagoya City University
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Wu Chun
Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya Univer
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