Increase in Bone Mass and Bone Strength by Sambucus williamsii HANCE in Ovariectomized Rats(Pharmacology)

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概要

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• Herbal Sambucus williamsii HANCE (SWH) is a folk medicine with a long history of safe use for treatment of bone fractures and joint diseases in China. The present study was designed to investigate if SWH extract could be used for treatment of postmenopausal osteoporosis. SWH extracts (30 or 60mg/100g body weight/d) were orally administrated to four-months-old ovariectomized (OVX) rats for 3 months. SWH extracts did not alter weight gain and uterus weight in OVX rats. SWH extracts significantly increased serum Ca levels (p<0.05, vs. OVX control group) as well as decreased urinary Ca excretion (p<0.01, vs. OVX control group) in OVX rats. The upregulation of serum alkaline phosphatase, serum osteocalcin as well as urinary deoxypyridinoline levels by OVX was suppressed by treatment with SWH extracts in rats (p<0.05, vs. OVX control group). SWH extract increased the stiffness of femur at both dosage (p<0.05, vs. OVX control group) and increased tibial bone mineral density at 60mg/100g body weight/d (p<0.05, vs. OVX control group) in OVX rats. Our results indicate that orally administrated SWH extracts can decrease urinary calcium excretion and bone turnover rate in OVX rats, resulting in positive effects on biomechanical strength of bone and bone mineral density. This study is the first to report that SWH could be considered as a potential candidate for management of postmenopausal osteoporosis. Then in vitro experiments were performed to determine the potential molecular mechanism of the anti-osteo-porotic effect of SWH. Results suggested that chloroform fraction and ethyl acetate fraction of SWH can inhibit osteoclastogenesis osteoclast by modulating the expression of osteoprotegrin (OPG) and receptor activator of NFKB ligand (RANKL) mRNA in osteoblastic UMR 106 cells. Both of them increased OPG mRNA and decreased RANKL mRNA expression, resulting in a dose-dependent increase in OPG/RANKL mRNA ratio (p<0.01, vs. vehicle-treated). Taken together, SWH treatment can effectively suppress the OVX-induced increase in bone turnover and its effects might be mediated by a decrease in osteoclastogenesis.

• 公益社団法人日本薬学会の論文
• 2005-10-01

著者

• ZHANG Yan

  Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science,

• WU Chun-Fu

  School of Pharmacy, Shenyang Pharmaceutical University

• Wu Chun

  Department Of Pharmacognosy Faculty Of Pharmaceutical Sciences Nagoya City University

• ZHANG Yan

  State Key Laboratory of Chinese Medicine and Molecular Pharmacology

• Yao Xin

  Medical College Jinan University

• Yao Xin-sheng

  Inst. Of Traditional Chinese Medicine And Natural Products Jinan Univ.

• Yao Xin-sheng

  School Of Traditional Chinese Materia Medicine Shengyang Pharmaceutical Univ.

• Yao Xin

  Department Of Natural Products Chemistry Shenyang Pharmaceutical University

• Wu Chun-fu

  中華人民共和国

• Wu Chun-fu

  School Of Pharmacy Shenyang Pharmaceutical University

• Wu Chun-fu

  Department Of Pharmacology Shenyang Pharmaceutical University College Of Life Science And Biopharmac

• Wong Man-sau

  Central Lab. Inst. Of Molecular Technol. For Drug Discovery And Synthesis Dep. Of Applied Biology An

• Wong Man-sau

  Central Laboratory Institute Of Molecular Technology For Drug Discovery And Synthesis Department Of

• Chan Albert

  State Key Lab. Of Chinese Medicine And Molecular Pharmacology

• XIE Fang

  Department of Pharmacology, Shenyang Pharmaceutical University

• CHEUNG Pik

  Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and S

• CHAN Albert

  Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and S

• WONG Man

  Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and S

• Cheung Pik

  Open Laboratory Of Chirotechnology Of The Institute Of Molecular Technology For Drug Discovery And S

• Xie Fang

  Department Of Pharmacology Shenyang Pharmaceutical University:state Key Laboratory Of Chinese Medici

• Wu Chun

  Department Of Electrical Engineering National Sun Yat-sen University

• Wu Chun

  Department Of Applied Molecular Bioscience Graduate School Of Bioagricultural Sciences Nagoya Univer

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