Cardenolides from Antiaris toxicaria as Potent Selective Nur77 Modulators
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概要
- 論文の詳細を見る
Toxicarioside D (1), a new cardenolide, along with 10 other known ones, was isolated from the stem of Antiaris toxicaria LESCH. by bioassay-guided fractionation. Their structures were determined on the basis of spectroscopic analysis. All the reported compounds effectively inhibited the growth of various cancer cell lines at nanomolar concentrations. Inhibition of cancer cell growth was accompanied with induction of the expression of Nur77, a potent apoptotic member of the steroid/thyroid hormone receptor superfamily.
- 社団法人日本薬学会の論文
- 2008-07-01
著者
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Yao Xin-sheng
Medical College Jinan University
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Yao Xin
Medical College Jinan University
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Dai Yi
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University
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Wang Guang-hui
Institute for Biomedical Research, Xiamen University
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Gao Hao
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University
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Yao Xin-sheng
College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
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Hu Qiong-ying
Burnham Institute For Medical Research
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Yao Xin-sheng
Inst. Of Traditional Chinese Medicine And Natural Products Jinan Univ.
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Yao Xin-sheng
School Of Traditional Chinese Materia Medicine Shengyang Pharmaceutical Univ.
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Yao Xin-sheng
College Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University
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Zhang Xue
Coll. Of Traditional Chinese Materia Medica Shenyang Pharmaceutical Univ.
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Zhang Xue
College Of Traditional Chinese Medicine Shenyang Pharmaceutical University
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Gao Hao
Institutes Of Traditional Chinese Medicine And Natural Products Jinan University
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Gao Hao
Department Of Natural Products Chemistry Shenyang Pharmaceutical University
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JIANG Miao-Miao
College of Traditional Chinese Medicine, Shenyang Pharmaceutical University
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HE Jia-You
Institute for Biomedical Research, Xiamen University
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ZENG Jin-Zhang
Institute for Biomedical Research, Xiamen University
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ZHANG Xiao-Kun
Burnham Institute for Medical Research
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Yao Xin-sheng
College Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University:shenzhen Research C
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He Jia-you
Institute For Biomedical Research Xiamen University
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Zeng Jin-zhang
Institute For Biomedical Research Xiamen University
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Dai Yi
Institute Of Industrial Science The University Of Tokyo
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Jiang Miao-miao
College Of Traditional Chinese Medicine Shenyang Pharmaceutical University
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Yao X‐s
Inst. Of Traditional Chinese Medicine And Natural Products Jinan Univ.
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Yao X‐s
Coll. Of Traditional Chinese Materia Medica Shenyang Pharmaceutical Univ.
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Zhang Xue
College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
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Dai Yi
Institute of Traditional Chinese Medicine & Natural Products, Jinan University
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