The Anti-stress Effects of Sarcandra glabra Extract on Restraint-Evoked Immunocompromise(Pharmacology)
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概要
- 論文の詳細を見る
Sarcandra glabra was a renowned herb traditionally used as herbal tea or food supplement to enhance mental efficiency and to recover from stress or fatigue in China. We investigated the effects of Sarcandra glabra extract (SGE), with chemical composition clearly showed by HPLC fingerprint as quality control, on immunologic response including natural killer (NK) cell activity and its antioxidative capacity in splenocytes obtained from restraint mice. Our results found that daily oral administration of SGE (125, 500mg/kg/d) for 5 consecutive days to restrained mice alleviated the stress-induced reduction of the number of lymphocytes, the balance of CD4^+ T/CD8^+ T and NK cell activity per spleen. SGE also significantly decreased the level of lipid peroxidation and increased oxygen radical absorbance capacity (ORAC) in splenocytes. These results indicated that SGE modulate stress-attenuated immunologic response, at least, partially explained by improving antioxidative capacity in immunocytes.
- 社団法人日本薬学会の論文
- 2009-02-01
著者
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Yao Xin-sheng
Medical College Jinan University
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Yao Xin
Medical College Jinan University
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Dai Yi
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University
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Yao Xin-sheng
Inst. Of Traditional Chinese Medicine And Natural Products Jinan Univ.
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Yao Xin-sheng
School Of Traditional Chinese Materia Medicine Shengyang Pharmaceutical Univ.
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KURIHARA Hiroshi
Institute of Traditional Chinese Medicine & Natural Products, Jinan University
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HE Rong
College of Traditional Chinese Materia Medica, Shengyang Pharmaceutical University
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YAO Xin
College of Traditional Chinese Materia Medica, Shengyang Pharmaceutical University
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LI Hui
Institute of Traditional Chinese Medicine & Natural Products, Jinan University
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DUAN Ying
College of Traditional Chinese Materia Medica, Shengyang Pharmaceutical University
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LI Yi
Institute of Traditional Chinese Medicine & Natural Products, Jinan University
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Duan Ying
College Of Traditional Chinese Materia Medica Shengyang Pharmaceutical University
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Li Hui
Institute Of Traditional Chinese Medicine & Natural Products Jinan University
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Yao Xin-sheng
College Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University:shenzhen Research C
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Kurihara Hiroshi
Institute Of Traditional Chinese Medicine And Natural Products Jinan University
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Kurihara Hiroshi
Institute Of Traditional Chinese Medicine & Natural Products Jinan University
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Li Yi
Institute Of Traditional Chinese Medicine & Natural Products Jinan University
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Dai Yi
Institute Of Traditional Chinese Medicine & Natural Products Jinan University
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Dai Yi
Institute Of Industrial Science The University Of Tokyo
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Yao X‐s
Inst. Of Traditional Chinese Medicine And Natural Products Jinan Univ.
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Yao X‐s
Coll. Of Traditional Chinese Materia Medica Shenyang Pharmaceutical Univ.
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He Rong
Institute Of Traditional Chinese Medicine & Natural Products Jinan University
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Li Yi
Institute Of Textiles And Clothing The Hong Kong Polytechnic University
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YAO Xin
College of Information Science and Engineering in Hunan University
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