Protective Effects of Radix Rosa laevigata against Propionibacterium acnes and Lipopolysaccharide-Induced Liver Injury
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概要
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We investigated the effects of an extract of Radix Rosa laevigata (R. R. laevigata) on Propionibacterium acnes (P. acnes) and lipopolysaccharide (LPS)-induced acute liver injury. The plasma alanine aminotransferase (ALT) activity was significantly elevated by an intravenous injection of heat-killed P. acnes at a dose of 0.4 mg/mouse and then with LPS at 0.1 μg/mouse after 5 d. However, the elevated ALT activity was significantly reduced by the administered of R. R. laevigata (125 and 500 mg/kg/d) for 7 d before the LPS injection. In addition, the extract treatment reduced the number of liver mononuclear cells (MNCs), and malondialdehyde (MDA) and nitric oxide (NO) contents, but improved the liver oxygen radical absorbance capacity (ORAC) and mitochondrial membrane potential. Moreover, the chemical profile of R. R. laevigata was performed by high-performance liquid chromatography (HPLC) and the main peaks were identified as a series of polyphenol compounds which had been confirmed as the significantly active components by their anti-oxidative and NO inhibitory effects. These results suggest that the extract of R. R. laevigata offered good efficacy for preventing liver injury.
著者
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YAO Xin-Sheng
School of Chinese Materia Medica, Shenyang Pharmaceutical University
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Yao Xin-sheng
Medical College Jinan University
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Dai Yi
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University
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Gao Hao
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University
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WANG Min
Institute of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and
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YAO Nan
Institute of Traditional Chinese Medicine & Natural Products, Jinan University
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KURIHARA Hiroshi
Institute of Traditional Chinese Medicine & Natural Products, Jinan University
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Yao Xin-sheng
College Of Traditional Chinese Materia Medica Shenyang Pharmaceutical University:shenzhen Research C
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He Rong-Rong
School of Traditional Chinese Materia Medicine, Shengyang Pharmaceutical University
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YU Yang
School of Traditional Chinese Materia Medicine, Shengyang Pharmaceutical University
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Yao X‐s
Coll. Of Traditional Chinese Materia Medica Shenyang Pharmaceutical Univ.
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