Anti-Tumor Activities of the Antlered Form of Ganoderma lucidum in Allogeneic and Syngeneic Tumor-Bearing Mice

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概要

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• We investigated the anti-tumor effects of a dry powder preparation of the antlered form of Ganoderma lucidum (G. lucidum AF, rokkaku-reishi in Japanese), a variant type of G. lucidum, not only in allogeneic Sarcoma 180-bearing ddY mice, but also in syngeneic MM 46-bearing C3H/He mice. G. lucidum AF inhibited tumor growth and elongated the life span when orally administered to mice by free-feeding of a 2.5% G. lucidum AF-containing diet. It also showed anti-tumor activity in spite of post-feeding after tumor inoculation. G. lucidum AF significantly countered the depression of splenic CD8+ cells and protected the decrease in interferon-gamma (IFN-γ) production in regional lymph nodes of MM 46-bearing mice, indicating that the anti-tumor activity of G. lucidum AF might be caused by its immunostimulating action. These results suggest that the ingestion of G. lucidum AF can be useful for the prevention and curing of cancer.

• 社団法人 日本農芸化学会の論文
• 2007-09-23

著者

• KISO Yoshinobu

  Institute for Health Care Science, Suntory Ltd.

• SHIBATA Hiroshi

  Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.

• Abe Shigeru

  Departments Of Radiology And Cardiology Yamagata Prefectural Shinjo Hospital

• Abe S

  Teikyo Univ. Tokyo Jpn

• Kiso Yoshinobu

  Institute For Biomedical Research Suntory Ltd.

• NAKAI Masaaki

  Institute for Materials Research, Tohoku University

• ABE SHIGERU

  Institute of Medical Mycology, Teikyo University

• YAMAGUCHI HIDEYO

  Institute of Medical Mycology, Teikyo University

• KURIHARA Hiroshi

  Institute of Traditional Chinese Medicine & Natural Products, Jinan University

• Tanaka Takaharu

  Institute For Health Care Science Suntory Ltd.

• Shibata H

  Laboratory For Health Care Science Research Center Suntory Ltd.

• NONAKA Yuji

  Institute for Health Care Science, Suntory Ltd.

• ISHIBASHI Hiroko

  Institute of Medical Mycology, Teikyo University

• MATSUE Hajime

  Aomori Advanced Industrial Technology Center

• Abe Shigeru

  Institute Of Medical Mycology Graduate School Of Medical Science Teikyo University

• Matsue Hajime

  Aomori University Of Health And Welfare

• Motomura Shigeru

  Hirosaki University School Of Medicine

• Furukawa Ken-ichi

  Hirosaki University School Of Medicine

• Abe Kaoru

  Hirosaki University School Of Medicine

• KUSHIBIKI Toshisada

  Kanesho Co., Ltd.

• Tanaka Takaharu

  Institute For Biomedical Research Suntory Ltd.

• Kushibiki Toshisada

  Kanesho Co. Ltd.

• Yamaguchi Hideyo

  Institute Of Medical Mycology And Genome Research Center Teikyo University

• Nonaka Yuji

  Hirosaki University School of Medicine

• Shibata Hiroshi

  Kanesho Co., Ltd.

• Nakai Masaaki

  Aomori University of Health and Welfare

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