First Chemical Synthesis of Antioxidative Metabolites of Sesamin
スポンサーリンク
概要
- 論文の詳細を見る
The first chemical synthesis of two metabolites ((1R,2S,5R,6S)-6-(3,4-dihydroxyphenyl)-2-(3,4-methylene-dioxyphenyl)-3,7-dioxabicyclo[3,3,0]octane (SC-1) and (1R,2S,5R,6S)-2,6-bis (3,4-dihydroxyphenyl)-3,7-dioxabicyclo[3,3,0] octane (SC-2)) of sesamin was achieved by a simple two-step approach from sesamin. The approach consists of acetoxylation of the methylenedioxy moiety(ies) with lead(IV) tetraacetate and acid hydrolysis of the resulting hemiorthoester to SC-1 and SC-2.
- 公益社団法人日本薬学会の論文
- 2008-11-01
著者
-
KISO Yoshinobu
Institute for Health Care Science, Suntory Ltd.
-
Kiso Yoshinobu
Laboratory For Health Care Science Research Center Suntory Ltd.
-
Kiso Yoshinobu
Institute For Biomedical Research Suntory Ltd.
-
Matsumura Yasuo
Osaka University of Pharmaceutical Sciences Osaka Medical College
-
Urata Hidehito
Osaka University of Pharmaceutical Sciences
-
Kiso Yoshinobu
Suntory Ltd. Osaka Jpn
-
Matsumura Yasuo
Osaka University Of Pharmaceutical Sciences
-
Wada Shun-ichi
Osaka University Of Pharmaceutical Sciences
-
Urata Hidehito
Osaka College Of Pharmacy
-
Ono Yoshiko
Institute For Health Care Science Suntory Ltd.
-
TOMIMORI NAMINO
Institute for Health Care Science, Technological Development Center, Suntory Ltd.
-
NISHIOKA Yuka
Osaka University of Pharmaceutical Sciences
-
TOBASHI Takafumi
Osaka University of Pharmaceutical Sciences
-
Tomimori Namino
Institute For Health Care Science Technological Development Center Suntory Ltd.
-
TOYODA ONO
Suntory Institute for Health Care Science
-
Kajimoto Yoshinaga
Institute For Health Care Science Suntory Ltd.
-
Kiso Yoshinobu
Institute For Health Care Science Suntory Wellness Limited
-
Kitagawa Yoshinori
Institute For Health Care Science Suntory Wellness Limited
-
Tomimori Namino
Institute For Health Care Science Suntory Wellness Limited
-
Ono Yoshiko
Institute For Health Care Science Suntory Wellness Limited
関連論文
- Antitumor and antimetastatic actions by royal jelly in Lewis lung carcinoma-bearing mice
- Antihypertensive Effects of Sesamin in Humans
- ショウガの抗肥満作用について
- デンプンおよびショ糖負荷マウスにおけるオリーブ葉エキスの血糖値に及ぼす影響
- J-1 天然にがりの抗腫瘍効果
- 昆布由来フコイダン含有食品の抗腫瘍効果とその作用機構
- P-86 高脂肪食誘発肥満に及ぼす竹節人参サポニンの作用
- P-16 ローヤルゼリーの抗腫瘍および抗転移効果とその作用機構
- Agaricus blazei Murill の抗腫瘍作用とその副作用 : 第2報 : 癌
- Agaricus blazei Murill の抗腫瘍作用とその副作用 : 第1報 : 癌
- 28D-05 柳の葉 (Salix matsudana (Salicaceae)) の高脂肪食投与マウスに及ぼす影響
- 食後の血中トリアシルグリセロールの上昇に及ぼすアカショウマエキスの影響
- B-013(30) 生姜の膵リパーゼ阻害作用およびその抗肥満作用
- S-3 膵リパーゼ阻害作用のある機能性物質について
- A-1 お茶由来のサポニンの抗肥満作用
- Studies on Scutellariae Radix. XII. Anti-thrombic Actions of Various Flavonoids from Scutellariae Radix
- Effect of Lactobacillus pentosus S-PT84 Ingestion on IFN-α Production from Plasmacytoid Dendritic Cells by Virus Stimulation
- Anti-Atherosclerotic Effects of Dihomo-γ-Linolenic Acid in ApoE-Deficient Mice
- Effects of tuna oil on tumor growth and metastasis to liver in intrasplenic Lewis lung carcinoma (LLC)-implanted mice
- Effects of the nonsugar fraction of brown sugar on chronic ultraviolet B irradiation-induced photoaging in melanin-possessing hairless mice
- D-037(31) EPA および共役 EPA の抗腫瘍および抗転移効果
- 31C-08 血管内皮細胞における t-PA, PAI-1 産生および接着分子発現に及ぼすバイカレインの影響
- Carnosine Modulates Stress-Attenuated Plasma Antioxidative Capacity
- Studies on Scutellariae Radix. VII. Anti-arthritic and Anti-inflammatory Actions of Methanolic Extract and Flavonoid Components from Scutellariae Radix
- Effects of Dietary Arachidonic Acid Supplementation on Age-Related Changes in Endothelium-Dependent Vascular Responses
- Synaptic plasticity preserved with arachidonic acid diet in aged rats
- Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
- EFFECTS OF BAICALEIN ON LEUKOTRIENE C_4 BIOSYNTHESIS IN HUMAN LEUKOCYTE
- Effects of Flavonoids and Related Compounds from Mulberry Tree on Arachidonate Metabolism in Rat Platelet Homogenates
- Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VII. Effects of Extracts of Leaves of Artemisia Species, and Caffeic Acid and Chlorogenic Acid on Lipid Metabolic Injury in Rats Fed Peroxidized Oil
- Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. VI. Inhibitory Effects of Caffeoylquinic Acids on Histamine Release from Rat Peritoneal Mast Cells
- Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. IV. Effects of Various Extracts of Geranii herba and Geraniin on Liver Injury and Lipid Metabolism in Rats Fed Peroxidized Oil
- Studies on the Activities of Tannins and Related Compounds of Medicinal Plants and Drugs. III. Effects of Various Tannins and Related Compounds on Adrenocorticotropic Hormon-induced Lipolysis and Insulin-induced Lipogenesis from Glucose in Fat Cells. (2)
- Studies on the Activities of Tannins and Related Compounds of Medicinal Plants and Drugs. II. Effects of Various Tannins and Related Compounds on Adrenaline-induced Lipolysis in Fat Cells. (1)
- Studies on the Activities of Tannins and Related Compounds from Medicinal Plants and Drugs. I. Inhibitory Effects on Lipid Peroxidation in Mitochondria and Microsomes of Liver
- Effects of Geniposide isolated from Gardenia jasminoides on Metabolic Alterations in High Sugar Diet-fed Rats
- C-04 オリーブ葉の紫外線B波照射による皮膚老化および発癌に及ぼす影響(腫瘍,一般演題口演,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- 健康茶の抗肥満作用(3)成人女子の血漿脂質に及ぼす健康茶の影響
- 健康茶の抗肥満作用(2)健康茶製剤の高脂肪食誘発肥満マウスに及ぼす影響
- 健康茶の抗肥満作用(1)各健康茶素材のラット脂肪細胞における脂肪分解および膵臓リパーゼ活性に及ぼす影響
- 薬用植物桔梗の抗肥満作用とその作用機序 : 脂質・循環器
- 日本酒および酒粕中の血管弛緩作用成分
- 28D-10 シスプラチンとキトサンの併用制癌効果
- 黒砂糖中の黒色物質の糖および脂質代謝に及ぼす影響
- 30A-05 キチン・キトサンの抗肥満作用
- Oral Supplementation with Dihomo-γ-linolenic Acid-Enriched Oil Altered Serum Fatty Acids in Healthy Men
- Antitumor and antimetastatic actions of anthrone-C-glucoside, cassialoin isolated from Cassia garrettiana heartwood in colon 26-bearing mice
- Anti-Tumor Activities of the Antlered Form of Ganoderma lucidum in Allogeneic and Syngeneic Tumor-Bearing Mice
- Anti-Stress Effect of BRAND'S Essence of Chicken (BEC) on Plasma Glucose Levels in Mice Loaded with Restraint Stress
- Antihypertensive Effect of Angiotensin I-Converting Enzyme Inhibitory Peptides from a Sesame Protein Hydrolysate in Spontaneously Hypertensive Rats
- The Protective Effect of BRAND'S Essence of Chicken (BEC) on Energy Metabolic Disorder in Mice Loaded with Restraint Stress
- Anti-Stress Effect of Oolong Tea in Women Loaded with Vigil
- Influence of Histamine in a Liver Injury Model Induced by Propionibacterium acnes and Lipopolysaccharide(Pharmacology)
- Pharmacology in Health Foods:Effects of Arachidonic Acid and Docosahexaenoic Acid on the Age-Related Decline in Brain and Cardiovascular System Function
- The Relationships of Cardiovascular Disease Risk Factors to Flow-Mediated Dilatation in Japanese Subjects Free of Cardiovascular Disease
- Effects of Compounds in Leaves of Salix matsudana on Arachidonic Acid Metabolism
- The Mechanism Underlying the Synergetic Hypocholesterolemic Effect of Sesamin and α-Tocopherol in Rats Fed a High-Cholesterol Diet
- Bio-pharmacological action of natural products isolated from medicinal plants : Flavonoids (baicalein and baicalin) and stilbenes (resveratrol and cassigarol A)(Chemical & Pharmacological study)
- Scutellariae Radix. X. Inhibitory Effects of Various Flavonoids on Histamine Release from Rat Peritoneal Mast Cells in Vitro
- Dietary Supplementation of L-Carnosine Prevents Ischemia/Reperfusion-Induced Renal Injury in Rats(Pharmacology)
- Effects of Sesamin on Aortic Oxidative Stress and Endothelial Dysfunction in Deoxycorticosterone Acetate-Salt Hypertensive Rats (Pharmacology)
- Inhibitory Effect of Oolong Tea on the Oxidative State of Low Density Lipoprotein (LDL)
- Antihypertensive Effect of Sesamin. IV. Inhibition of Vascular Superoxide Production by Sesamin
- Preventive Effect of a Chicken Extract on the Development of Hypertension in Stroke-prone Spontaneously Hypertensive Rats(Food & Nutrition Science)
- Antihypertensive Effects of Chicken Extract against Deoxycorticosterone Acetate-Salt-Induced Hypertension in Rats
- Low-Calorie Diet-Induced Reduction in Serum HDL Cholesterol Is Ameliorated in Obese Women with the -3826 G Allele in the Uncoupling Protein-1 Gene
- Preventive Effect of Flavangenol on Ischemia/Reperfusion-Induced Acute Renal Failure in Rats(Pharmacology)
- Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis
- Anti-obesity Effects of Escins Extracted from the Seeds of Aesculus turbinata BLUME (Hippocastanaceae)
- 植物発酵食品の抗腫瘍効果と肺転移に及ぼす影響
- II-A-17 黒砂糖中に含まれる糖輸送抑制物質
- First Chemical Synthesis of Antioxidative Metabolites of Sesamin
- Comparison of the Immunomodulatory Effects of Live and Heat-killed Lactobacillus pentosus S-PT84
- Antitumor activities of synthetic and natural stilbenes through antiangiogenic action
- Antitumor actions of a chromone glucoside cnidimoside A isolated from Cnidium japonicum
- Isolation of an anti-angiogenic substance from Agaricus blazei Murill : Its antitumor and antimetastatic actions
- Fragrances in Oolong Tea That Enhance the Response of GABA_A Receptors
- Effect of Xylooligosaccharide Intake on Severe Constipation in Pregnant Women
- Pharmacology in Health Foods:Improvement of Vascular Endothelial Function by French Maritime Pine Bark Extract (Flavangenol)
- Effect of Dietary Enrichment with n-3 Polyunsaturated Fatty Acids (PUFA) or n-9 PUFA on Arachidonate Metabolism in Vivo and Experimentally Induced Inflammation in Mice (Biochemistry/Molecular Biology)
- Clinical Study on the Combined Effect of Capsaicin, Green Tea Extract and Essence of Chicken on Body Fat Content in Human Subjects
- Effects of Chicken Essence Tablets on Resting Metabolic Rate(Food & Nutrition Science)
- Identification of the Major Antioxidative Metabolites in Biological Fluids of the Rat with Ingested (+)-Catechin and (-)-Epicatechin
- Recent Trends in Functional Food Science and the Industry in Japan
- Effects of Flavangenol on Autonomic Nerve Activities and Dietary Body Weight Gain in Rats
- Effects of Flavangenol on Autonomic Nerve Activities and Dietary Body Weight Gain in Rats
- Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis
- 30C-05 5-FU とキチン・キトサンの併用制癌効果
- Effects of the Antlered Form of Ganoderma lucidum on Tumor Growth and Metastasis in Cyclophosphamide-Treated Mice
- Suppression of Postprandial Hypertriglyceridemia in Rats and Mice by Oolong Tea Polymerized Polyphenols
- Dietary Sesame Lignans Decrease Lipid Peroxidation in Rats Fed Docosahexaenoic Acid
- Oral Supplementation with Dihomo-γ-linolenic Acid-Enriched Oil Altered Serum Fatty Acids in Healthy Men
- P2-40 Effect of Flavangenol of movement tiredness recovery in long distance runner(The Proceedings of the 12th Annual Meetings of Japan Society of Exercise and Sports Physiology)
- Effect of Lactobacillus pentosus S-PT84 Ingestion on IFN-α Production from Plasmacytoid Dendritic Cells by Virus Stimulation
- Influence of Lactobacillus pentosus S-PT84 Ingestion on the Mucosal Immunity of Healthy and Salmonella Typhimurium-Infected Mice
- Antitumor and antimetastatic actions by royal jelly in Lewis lung carcinoma-bearing mice
- Effects of carp extract on tumor growth in spleen and number of colonies of Lewis lung carcinoma (LLC) cells metastasizing to liver in intrasplenic LLC-implanted mice
- Studies on Scutellariae Radix. VI. Effects of Flavanone Compounds on Lipid Peroxidation in Rat Liver
- Pharmacology in Health Foods : Improvement of Vascular Endothelial Function by French Maritime Pine Bark Extract (Flavangenol)
- The Mechanism Underlying the Synergetic Hypocholesterolemic Effect of Sesamin and α-Tocopherol in Rats Fed a High-Cholesterol Diet