Preventive Effect of Flavangenol on Ischemia/Reperfusion-Induced Acute Renal Failure in Rats(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
The effects of flavangenol on ischemia/reperfusion-induced acute renal failure (ARF) in rats were examined. Ischemic ARF was induced by occlusion of the left renal artery and vein for 45min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal functional parameters such as blood urea nitrogen, plasma creatinine, creatinine clearance, urine flow, urinary osmolality and fractional excretion of sodium were measured. Renal function in ARF rats markedly decreased at 1d after reperfusion. Pre-ischemic treatment with flavangenol (3-30mg/kg, i.v.) attenuated the ischemia/reperfusion-induced renal dysfunction. Histopathological examination of the kidney of ARF rats revealed severe renal damage, such as tubular necrosis and proteinaceous casts in tubuli, which were also significantly suppressed by the administration of flavangenol. These findings suggest that flavangenol supplementation may be a promising candidate for treatments to improve the ischemia/reperfusion-induced renal injury.
- 公益社団法人日本薬学会の論文
- 2005-09-01
著者
-
KISO Yoshinobu
Institute for Health Care Science, Suntory Ltd.
-
MATSUMURA Yasuo
Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences
-
Takaoka Masanori
Department Of Internal Medicine Iii Osaka Medical College
-
NAKAJIMA ATSUSHI
Department of Gastroenterology, Yokohama City University School of Medicine
-
MATSUMURA Yasuo
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
-
Kiso Yoshinobu
Laboratory For Health Care Science Research Center Suntory Ltd.
-
Kiso Yoshinobu
Institute For Biomedical Research Suntory Ltd.
-
Kiso Yoshinobu
Suntory Ltd. Osaka Jpn
-
Matsumura Yasuo
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
-
Matsumura Yasuo
Department Of Pharmacology Osaka University Of Phiarmaceutical Sciences
-
Matsumura Yasuo
Department Of Mechanical Physics Kyoto University
-
Nakajima Atsushi
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
-
Takaoka Masanori
Department Of Electrical And Electronic Engineering University Of Miyazaki
-
Matsumura Y
Asahi Glass Co. Ltd. Tokyo Jpn
-
Ueda Kyoko
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
-
Okabe Makoto
Third Division Department Of Internal Medicine Osaka Medical College
-
Mori Tatsuhiko
Third Department Of Medicine Osaka Medical College
-
OHKITA Mamoru
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
-
Takaoka M
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
-
Okabe Makoto
The Third Division Internal Medicine Osaka College
-
Kajimoto Yoshinaga
Institute For Health Care Science Suntory Ltd.
-
Kitagawa Yoshinori
Institute For Health Care Science Suntory Wellness Limited
-
Nakajima Atsushi
Department Of Gastroenterology Yokohama City University Graduate School Of Medicine
-
Nakajima Atsushi
Department Of Chemistry Faculty Of Science And Technology Keio University
-
Mori Tatsuhiko
Department Of Gastroenterology And Neurology Faculty Of Medicine Kagawa University
関連論文
- Antihypertensive Effects of Sesamin in Humans
- Drug Discovery for Overcoming Chronic Kidney Disease (CKD) : The Endothelin ET_B Receptor / Nitric Oxide System Functions as a Protective Factor in CKD
- Pitavastatin reduces oxidative stress and attenuates intermittent hypoxia-induced left ventricular remodeling in lean mice
- Adenosquamous carcinoma of the pancreas associated with humoral hypercalcemia of malignancy (HHM)
- Serum Butyrylcholinesterase is Strongly Associated with Adiposity, the Serum Lipid Profile and Insulin Resistance
- Effect of Lactobacillus pentosus S-PT84 Ingestion on IFN-α Production from Plasmacytoid Dendritic Cells by Virus Stimulation
- Anti-Atherosclerotic Effects of Dihomo-γ-Linolenic Acid in ApoE-Deficient Mice
- OJ-062 Effect of Chymase Inhibition by NK-3201 on Hypoxia-Induced Left Ventricular Remodeling in Mice(Cardiovascular pharmacology, basic/clinical(02)(H),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Bisphosphonate increases risk of gastroduodenal ulcer in rheumatoid arthritis patients on long-term nonsteroidal antiinflammatory drug therapy
- Angiotensin-II Receptor Blocker Exerts Cardioprotection in Diabetic Rats Exposed to Hypoxia(Experimental Investigation)
- OE-012 Angiotensin II Receptor Blocker Inhibits NF-κ B Activity and Prevents Hypoxia-Induced Fibrosis of Left Ventricular Myocardium in Apolipoprotein E-Knockout Mice(Chronic coronary heart disease/Remodeling-1 (IHD) OE2,Oral Presentation (English),The 70
- Chronic Hypoxia Accelerates the Progression of Atherosclerosis in Apolipoprotein E-Knockout Mice
- Nifedipine Enhances the Cardioprotective Effect of an Angiotensin-II Receptor Blocker in an Experimental Animal Model of Heart Failure
- Mechanisms of Combined Treatment With Celiprolol and Candesartan for Ventricular Remodeling in Experimental Heart Failure
- Ghrelin Improved Diastolic Dysfunction Induced by Hypoxia in Diabetic OLETF Rats(Heart Failure, Basic 5 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Nifedipine Decreases Oxidative Stress and Exhibits Cardiovascular Protection in Diabetic Rats Exposed to Hypoxia(Diabetes/Obesity 3 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PE-322 Hypoxia Induces Atherogenesis of Apolipoprotein E-knockout Mice through Superoxide Production(Atherosclerosis, Basic 5 (IHD) : PE55)(Poster Session (English))
- OE-320 Angiotensin-II Receptor Blocker Exhibits Cardioprotection through Modulation of Cytokine Expression in the Metabolic Syndrome Accompanied with Hypoxia(Diabetes/Obesity 2 (H) : OE40)(Oral Presentation (English))
- Nifedipine Enhances Cardioprotective Effect of Angiotensin-II Receptor Blocker in Progressive Heart Failure
- Endothelin ETA Receptor Antagonist Suppressed ET-1 Content and INOS but Could Not Improve the Cardiac Dysfunction in Dilated Cardiomyopathy
- Short-Term Treatment at Vascular Injury with a Free Radical Scavenger Effectively Blunted Vascular Injury Response in Diabetic Rats
- New Concept of Cardioprotection in Diabetes Mellitus from a Viewpoint of Intracellular Free-Thiol Stabilization by Ebselen
- The Base Specificities of Tomato Ribonuclease (RNase LE) and Its Asp44 Mutant Enzyme Expressed from Yeast Cells
- PJ-312 Intermittent Hypoxia Accelerates Cardiovascular Remodeling due to Postprandial Hyperglycemia in Lean Mice(PJ053,Metabolic Syndrome 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-425 Left Ventricular Remodeling Induced by Intermittent Hypoxia : Role of gp91phox Subunit of NADPH Oxidase(Heart failure, basic(04)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-398 Nuclear Factor-κ B Activation Accelerates Cardiac Hypertrophy, Interstitial Fibrosis, and Oxidative Stress in Diabetic Rats Exposed to Intermittent Hypoxia(Chronic coronary heart disease/Remodeling-2, The 71st Annual Scientific Meeting of the Japan
- Relationship between the Serum Concentrations of C-reactive Protein and Parameters of Adiposity and Insulin Resistance in Patients with Type 2 Diabetes Mellitus
- Angiotensin II Receptor Blocker Reduces Oxidative Stress and Attenuates Hypoxia-Induced Left Ventricular Remodeling in Apolipoprotein E-Knockout Mice
- Ovariectomized Female Rats Showed More Favorable Response to Statin-therapy for Vasoprotection than Male Rats against Vascular Injury(Atherosclerosis, Basic 8 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Selective Endothelin ET_B Receptor Antagonist Improves Left Ventricular Function but Exaggerates Degeneration of Cardiomyocytes in J2N-k Hamsters
- Angiotensin-II receptor antagonist combined with β-adrenergic blocker improves left ventricular systolic and diastolic dysfunction in advanced heart failure
- Changes in Serum Sex Hormone Profiles after Short-term Low-dose Administration of Dehydroepiandrosterone (DHEA) to Young and Elderly Persons
- Effects of Dietary Arachidonic Acid Supplementation on Age-Related Changes in Endothelium-Dependent Vascular Responses
- Synaptic plasticity preserved with arachidonic acid diet in aged rats
- Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction
- Oral Supplementation with Dihomo-γ-linolenic Acid-Enriched Oil Altered Serum Fatty Acids in Healthy Men
- Selective Antagonism of the ET_A Receptor, but Not the ET_B Receptor, Is Protective Against Ischemic Acute Renal Failure in Rats
- Anti-Tumor Activities of the Antlered Form of Ganoderma lucidum in Allogeneic and Syngeneic Tumor-Bearing Mice
- Anti-Stress Effect of BRAND'S Essence of Chicken (BEC) on Plasma Glucose Levels in Mice Loaded with Restraint Stress
- Antihypertensive Effect of Angiotensin I-Converting Enzyme Inhibitory Peptides from a Sesame Protein Hydrolysate in Spontaneously Hypertensive Rats
- The Protective Effect of BRAND'S Essence of Chicken (BEC) on Energy Metabolic Disorder in Mice Loaded with Restraint Stress
- Anti-Stress Effect of Oolong Tea in Women Loaded with Vigil
- Influence of Histamine in a Liver Injury Model Induced by Propionibacterium acnes and Lipopolysaccharide(Pharmacology)
- Studies of Elastic Waves in Ethylene Propylene Rubber Using Acoustic Emission Sensor
- Pharmacology in Health Foods:Effects of Arachidonic Acid and Docosahexaenoic Acid on the Age-Related Decline in Brain and Cardiovascular System Function
- The Relationships of Cardiovascular Disease Risk Factors to Flow-Mediated Dilatation in Japanese Subjects Free of Cardiovascular Disease
- Exaggerated Renal Pathology of Partial Ablation-Induced Chronic Renal Failure in eNOS Deficient Mice(Pharmacology)
- Tacrolimus in corticosteroid-resistant ulcerative colitis
- Xanthoangelol D Isolated from the Roots of Angelica keiskei Inhibits Endothelin-1 Production through the Suppression of Nuclear Factor-κB(Pharmacology)
- Dietary Supplementation of L-Carnosine Prevents Ischemia/Reperfusion-Induced Renal Injury in Rats(Pharmacology)
- Effects of Sesamin on Aortic Oxidative Stress and Endothelial Dysfunction in Deoxycorticosterone Acetate-Salt Hypertensive Rats (Pharmacology)
- Inhibitory Effect of Oolong Tea on the Oxidative State of Low Density Lipoprotein (LDL)
- Antihypertensive Effect of Sesamin. IV. Inhibition of Vascular Superoxide Production by Sesamin
- Preventive Effect of a Chicken Extract on the Development of Hypertension in Stroke-prone Spontaneously Hypertensive Rats(Food & Nutrition Science)
- Antihypertensive Effects of Chicken Extract against Deoxycorticosterone Acetate-Salt-Induced Hypertension in Rats
- Deflection-Flipping Waves in a Symmetric Channel with Spatially Periodic Expansions and Contractions(Electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid mechanics)
- Some Characteristics of Exact Strained Solutions to the Two Dimensional Navier-Stokes Equations
- Low-Calorie Diet-Induced Reduction in Serum HDL Cholesterol Is Ameliorated in Obese Women with the -3826 G Allele in the Uncoupling Protein-1 Gene
- Mucin-producing gallbladder adenocarcinoma with focal small cell and large cell neuroendocrine differentiation associated with pancreaticobiliary maljunction
- Effects of Pre- and Post-ischemic Treatments with FK409, a Nitric Oxide Donor, on Ischemia/Reperfusion-Induced Renal Injury and Endothelin-1 Production in Rats(Pharmacology)
- Preventive Effect of Flavangenol on Ischemia/Reperfusion-Induced Acute Renal Failure in Rats(Pharmacology)
- P7-16 Role of nitric oxide in the development and progression of ischemic acute renal failure in rats(IMMUNE AND ALLERGIC SYSTEM/KIDNEYS AND URINARY EXCRETION SYSTEM/CYTOTOXICITY/OTHERS-1)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st An
- Adiabatic Electron Affinities of Oligophenyls : Anion Photoelectron Spectroscopy and Density Functional Theory Study
- Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis
- First Chemical Synthesis of Antioxidative Metabolites of Sesamin
- Comparison of the Immunomodulatory Effects of Live and Heat-killed Lactobacillus pentosus S-PT84
- Sex Difference in Ischemic Acute Renal Failure in Rats : Approach by Proteomic Analysis(Pharmacology)
- Fragrances in Oolong Tea That Enhance the Response of GABA_A Receptors
- Effect of Xylooligosaccharide Intake on Severe Constipation in Pregnant Women
- Pharmacology in Health Foods:Improvement of Vascular Endothelial Function by French Maritime Pine Bark Extract (Flavangenol)
- Effect of Dietary Enrichment with n-3 Polyunsaturated Fatty Acids (PUFA) or n-9 PUFA on Arachidonate Metabolism in Vivo and Experimentally Induced Inflammation in Mice (Biochemistry/Molecular Biology)
- Clinical Study on the Combined Effect of Capsaicin, Green Tea Extract and Essence of Chicken on Body Fat Content in Human Subjects
- Effects of Chicken Essence Tablets on Resting Metabolic Rate(Food & Nutrition Science)
- Identification of the Major Antioxidative Metabolites in Biological Fluids of the Rat with Ingested (+)-Catechin and (-)-Epicatechin
- Recent Trends in Functional Food Science and the Industry in Japan
- Tempol Protects against Ischemic Acute Renal Failure by Inhibiting Renal Noradrenaline Overflow and Endothelin-1 Overproduction(Pharmacology)
- A Nuclear Factor-κB Inhibitor BAY 11-7082 Suppresses Endothelin-1 Production in Cultured Vascular Endothelial Cells
- Involvement of Proteasome in Endothelin-1 Production in Cultured Vascular Endothelial Cells
- Protective Effect of SM-19712, a Novel and Potent Endothelin Converting Enzyme Inhibitor, on Ischemic Acute Renal Failure in Rats
- Protective Effect of KB-R7943, a Novel Na^+/Ca^ Exchange Inhibitor, on Ischemic Acute Renal Failure in Rats
- Effects of Flavangenol on Autonomic Nerve Activities and Dietary Body Weight Gain in Rats
- Effects of Flavangenol on Autonomic Nerve Activities and Dietary Body Weight Gain in Rats
- Effects of an Oral Administration of Glucosamine-Chondroitin-Quercetin Glucoside on the Synovial Fluid Properties in Patients with Osteoarthritis and Rheumatoid Arthritis
- Effects of the Antlered Form of Ganoderma lucidum on Tumor Growth and Metastasis in Cyclophosphamide-Treated Mice
- Dietary Sesame Lignans Decrease Lipid Peroxidation in Rats Fed Docosahexaenoic Acid
- Chaotic Motions in an Oscillatory Soliton Lattice
- Oral Supplementation with Dihomo-γ-linolenic Acid-Enriched Oil Altered Serum Fatty Acids in Healthy Men
- P2-40 Effect of Flavangenol of movement tiredness recovery in long distance runner(The Proceedings of the 12th Annual Meetings of Japan Society of Exercise and Sports Physiology)
- Effect of Lactobacillus pentosus S-PT84 Ingestion on IFN-α Production from Plasmacytoid Dendritic Cells by Virus Stimulation
- Effect of Sodium Intake on Urinary Renin Excretion in Rats
- RENAL INACTIVE KALLIKREIN AS THE POSSIBLE ORIGIN OF URINARY INACTIVE KALLIKREIN IN THE RAT
- CONVERSION OF LOW MOLECULAR WEIGHT RENIN INTO THE HIGH MOLECULAR WEIGHT FORM BY Cu^ IN THE RAT KIDNEY
- Photoelectron Spectroscopy of Scandium-Arene Complex Anions
- Formation of Large Molecular Cluster Anions and Elucidation of Their Electronic Structures
- Homozygous Deletion of the Atrial Natriuretic Peptide Gene Exaggerated Cardiac Enlargement in Response to Volume Overload in Mice
- Effect of Efonidipine on TGF-β1-Induced Cardiac Fibrosis Through Smad2-Dependent Pathway in Rat Cardiac Fibroblasts
- Effects of Acarbose on the Acceleration of Postprandial Hyperglycemia-Induced Pathological Changes Induced by Intermittent Hypoxia in Lean Mice
- Pharmacology in Health Foods : Improvement of Vascular Endothelial Function by French Maritime Pine Bark Extract (Flavangenol)
- Roles of central renin-angiotensin system and afferent renal nerve in the control of systemic hemodynamics in rats
- Add-On Aliskiren Elicits Stronger Renoprotection Than High-Dose Valsartan in Type 2 Diabetic KKAy Mice That Do Not Respond to Low-Dose Valsartan