Antihypertensive Effect of Angiotensin I-Converting Enzyme Inhibitory Peptides from a Sesame Protein Hydrolysate in Spontaneously Hypertensive Rats
スポンサーリンク
概要
- 論文の詳細を見る
Sesame peptide powder (SPP) exhibited angiotensin I-converting enzyme (ACE) inhibitory activity, and significantly and temporarily decreased the systolic blood pressure (SBP) in spontaneously hypertensive rats (SHRs) by a single administration (1 and 10 mg/kg). Six peptide ACE inhibitors were isolated and identified from SPP. The representative peptides, Leu-Val-Tyr, Leu-Gln-Pro and Leu-Lys-Tyr, could competitively inhibit ACE activity at respective Ki values of 0.92 μM, 0.50 μM, and 0.48 μM. A reconstituted sesame peptide mixture of Leu-Ser-Ala, Leu-Gln-Pro, Leu-Lys-Tyr, Ile-Val-Tyr, Val-Ile-Tyr, Leu-Val-Tyr, and Met-Leu-Pro-Ala-Tyr according to their content ratio in SPP showed a strong antihypertensive effect on SHR at doses of 3.63 and 36.3 μg/kg, which accounted for more than 70% of the corresponding dosage for the SPP-induced hypotensive effect. Repeated oral administration of SPP also lowered both SBP and the aortic ACE activity in SHR. These results demonstrate that SPP would be a beneficial ingredient for preventing and providing therapy against hypertension and its related diseases.
- 社団法人 日本農芸化学会の論文
- 2006-05-23
著者
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KISO Yoshinobu
Institute for Health Care Science, Suntory Ltd.
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MATSUMURA Yasuo
Laboratory of Pathological and Molecular Pharmacology, Osaka University of Pharmaceutical Sciences
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Shibata Hiroko
Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation (nibio)
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Shibata Hiroko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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SHIBATA Hiroshi
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd.
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Takaoka Masanori
Department Of Internal Medicine Iii Osaka Medical College
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Akimoto Kengo
Institute For Health Care Science Suntory Ltd.
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MATSUMURA Yasuo
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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Kiso Yoshinobu
Laboratory For Health Care Science Research Center Suntory Ltd.
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Kiso Yoshinobu
Institute For Biomedical Research Suntory Ltd.
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Nakano Daisuke
Osaka University of Pharmaceutical Sciences Osaka Medical College
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NAKANO Daisuke
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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KWAK Chol-Jun
Osaka University of Pharmaceutical Sciences
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ISHII Fumie
Department of Pharmacology, Osaka University of Phiarmaceutical Sciences
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Kiso Yoshinobu
Suntory Ltd. Osaka Jpn
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Shibata Hiroshi
Laboratory For Health Care Science Research Center Suntory Ltd.
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Matsumura Yasuo
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Matsumura Yasuo
Department Of Pharmacology Osaka University Of Phiarmaceutical Sciences
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Matsumura Yasuo
Department Of Mechanical Physics Kyoto University
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Kawanishi Hideaki
Institute For Health Care Science Suntory Ltd.
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Takaoka Masanori
Department Of Electrical And Electronic Engineering University Of Miyazaki
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Miyakoshi Masazumi
Applied Chemistry Group Biological & Chemical Research Department Maruzen Pharmaceuticals Co. Lt
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Shibata H
Laboratory For Health Care Science Research Center Suntory Ltd.
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OGURA Kyoichi
Institute for Health Care Science, Suntory Ltd.
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KAWANISHI Hideaki
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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KURUMAZUKA Daisuke
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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KWAK Chol-jun
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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IKEMURA Kenji
Department of Pharmacology, Osaka University of Pharmaceutical Sciences
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MORIGUCHI Shigeo
Institute for Health Care Science, Suntory Ltd.
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IINO Taeko
Institute for Health Care Science, Suntory Ltd.
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KUSUMOTO Aki
Institute for Health Care Science, Suntory Ltd.
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ASAMI Sumio
Institute for Health Care Science, Suntory Ltd.
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Matsumura Y
Asahi Glass Co. Ltd. Tokyo Jpn
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Kawashima H
Institute For Health Care Science Research Center Suntory Ltd.
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Iino Taeko
Institute For Health Care Science Suntory Ltd.
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Asami S
Institute For Health Care Science Suntory Ltd.
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Ishii F
Department Of Pharmacology Osaka University Of Phiarmaceutical Sciences
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Kusumoto Aki
Institute For Health Care Science Suntory Ltd.
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Ogura Kyoichi
Institute For Health Care Science Suntory Ltd.
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Ikemura Kenji
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Nakano Daisuke
Osaka University Of Pharmaceutical Sciences
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Nakano Daisuke
Department Of Organic Chemistry Graduate School Of Pharmaceutical Sciences Tohoku University
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Mori Tatsuhiko
Third Department Of Medicine Osaka Medical College
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Kawashima Hideaki
Graduate School Of Pharmaceutical Sciences Kyoto University
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Takaoka M
Laboratory Of Pathological And Molecular Pharmacology Osaka University Of Pharmaceutical Sciences
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Kurihara H
Institute Of Traditional Chinese Medicine And Natural Products Jinan University
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Moriguchi Shigeo
Institute For Health Care Science Suntory Ltd.
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Kurumazuka Daisuke
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Kajimoto Yoshinaga
Institute For Health Care Science Suntory Ltd.
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Kitagawa Yoshinori
Institute For Health Care Science Suntory Wellness Limited
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Saito Hiroyuki
Third Department Of Internal Medicine Asahikawa Medical College
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Kawanishi Hideaki
Department Of Pharmacology Osaka University Of Pharmaceutical Sciences
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Shibata Hiroshi
Institute Of Health Care Science Suntory Wellness Limited
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Shibata Hiroshi
Institute For Drug Discovery Research Yamanouchi Pharmaceutical Co. Ltd.:department Of Animal Scienc
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Mori Tatsuhiko
Department Of Gastroenterology And Neurology Faculty Of Medicine Kagawa University
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SHIBATA Hiroshi
Institute for Biomedical Research, Suntory Limited
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