Selective Enhancer of Tumor Vascular Permeability for Optimization of Cancer Chemotherapy (Pharmacognosy)
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概要
- 論文の詳細を見る
Clinical approach using tumor necrosis factor-alpha (TNF-α as selective destruction against tumor endothelial cells and selective enhancer of tumor vascular permeability for effective accumulation of antitumor chemotherapeutic agents has attracted attention. However, the clinical application of TNF-α as a systemic antitumor agent has been limited because of toxic side-effects. To systemically use TNF-α as an antitumor agent and the selective enhancer of tumor vascular permeability, we assessed the usefulness of PEGylated TNF-α (PEG-TNF-α). PEG-TNF-α at a dose of 1000 JRU showed marked hemorrhagic necrosis in S-180 tumors without sideeffects due to selective destruction of tumor vasculature, whereas wild-type TNF-α at a dose of 10000 JRU showed a little hemorrhagic necrosis with severe side-effects. PEG-TNF-α induced the enhancement of tumor vascular permeability. The permeability was increased at 1 h, after an i. v. injection of PEG-TNF-α and returned to the basal level at 2 h. In addition, high molecular weight of PEG (molecular weight ; 500K) accumulated in tumor tissue as well as low molecular weight of PEG (molecular weight ; 12K). On the other hand, PEG-TNF-α didn't affect the permeability of normal tissue and inflammation site. This data suggested that PEG-TNF-α was useful agent as selective enhancer of tumor vascular permeability with safe.
- 社団法人日本薬学会の論文
- 2004-03-01
著者
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Yoshioka Yasuo
Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka Unive
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Abe Yasuhiro
Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio)
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Tsutsumi Yasuo
Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka Unive
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Mukai Yohei
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ
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Nakagawa Shinsaku
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ
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Kiwada Hiroshi
徳島大学 ヘルスバイオサイエンス研究部薬物動態制御学
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Kiwada Hiroshi
Faculty Of Pharmaceutifal Sciences The University Of Tokushima
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提 康央
Faculty Of Pharmaceutical Sciences Osaka University
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YAMAMOTO Yoko
Department of Materials Science and Engineering,Graduate School of Engineering,Osaka University
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真弓 忠範
Graduate School Of Pharmaceutical Sciences Kobe-gakuin Univ.
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真弓 忠範
大阪大学 薬 薬剤
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OKAMOTO Takayuki
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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MAYUMI Tadanori
Department of Cell Therapeutics, Graduate School of Pharmaceutical Sciences, Kobe Gakuin University
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村上 智彦
神戸学院大学 薬
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TANIAI Madoka
Hayashibara Biochemical Laboratories, Inc.
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Tsunoda S
Lab. Of Pharmaceutical Proteomics National Inst. Of Biomedical Innovation (nibio)
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Shibata Hiroko
Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation (nibio)
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Shibata Hiroko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Nakagawa S
Graduate School Of Pharmaceutical Sciences Osaka University
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Nakagawa S
Osaka Univ. Osaka Jpn
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Nakagawa Shinsaku
中華人民共和国
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Mukai Yohei
Graduate School Of Pharmaceutical Sciences Osaka University
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Mukai Yohei
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Higashisaka Kazuma
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Kamada Haruhiko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Kamada Haruhiko
Laboratory Of Pharmaceutical Proteomics (lpp) National Institute Of Biomedical Innovation (nibio)
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Abe Yasuhiro
Lab. Of Pharmaceutical Proteomics National Inst. Of Biomedical Innovation (nibio)
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Abe Yasuhiro
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Sugita Toshiki
Lab. Of Pharmaceutical Proteomics National Inst. Of Biomedical Innovation
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Sugita Toshiki
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Sugita Toshiki
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University
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Tsutsumi Y
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Yoshioka Yasuo
Department Of Radiation Oncology Osaka University Graduate School Of Medicine
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Yoshioka Yasuo
大阪大学 医学系研究科放射線治療学
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Kiwada Hiroshi
Department Of Pharmacokinetics And Biopharmaceutics Faculty Of Pharmaceutical Sciences The Universit
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Yoshioka Yasuo
Dept. Of Radiation Oncology Osaka University Graduate School Of Medicine
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Tsujino Masaki
大阪大学 薬学研究科薬剤学
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Morishita Yuki
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Morishita Yuki
大阪大学 薬学研究科毒性学
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KAMADA Haruhiko
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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KIHIRA Tetsuya
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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TSUNODA Shin-ichi
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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SHIBATA Hiroko
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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TANIAI Madoka
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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SHIMIZU Tomoe
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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KAWAMURA Maki
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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ABE Yasuhiro
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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Shimizu Tomoe
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University
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Kihira Tetsuya
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University
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Kihira Tetsuya
大阪大学 薬研究薬剤学
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Tsutsumi Yasuo
Department Of Electrical Engineering Akashi College Of Technology
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Kamiya Hiroyuki
Lab. For Molecular Design Of Pharmaceutics Fac. Of Pharmaceutical Sciences Hokkaido Univ.
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Kamada H
Yamagata Technopolis Foundation Yamagata Jpn
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Kamada Hitoshi
Institute For Life Support Technology Yamagata Promotional Organization For Industrial Technology
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Yoshioka Yasuo
Dept. Of Energy Science And Engineering Musashi Inst. Of Tech.
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Tsunoda Saburo
Divisions Of Medical Oncology Tochigi Cancer Center
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Mayumi Tadanori
Faculty Of Pharmacy Osaka University
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Mayumi Tadanori
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Mayumi Tadanori
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Science Osaka University
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Shibata Hiroshi
Laboratory For Health Care Science Research Center Suntory Ltd.
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Nakagawa Shinsaku
Dep. Of Biotechnology And Therapeutics Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Nakagawa Shinsaku
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University
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Abe Yasuhiro
Department Of Applied Physics Hokkaido University
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Shibata H
Laboratory For Health Care Science Research Center Suntory Ltd.
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Taniai Madoka
Hayashibara Biochemical Laboratories Inc.
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堤 康央
医薬基盤研究所:大阪大学大学院薬学研究科:大阪大学臨床医工学融合研究教育センター
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Kamada H
Institute For Life Support Technology Yamagata Promotional Organization For Industrial Technology
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Kiwada H
Faculty Of Pharmaceutifal Sciences The University Of Tokushima
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Yamashiro Y
Osaka Univ. Suita Jpn
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Okamoto Tatsuyuki
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University:departmen
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Mayumi Tadanori
Faculty Of Pharmaceutical Sciences Kobe-gakuin University:faculty Of Pharmaceutical Sciences Osaka U
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Tsutsumi Yasuo
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Momose T
大阪大学薬学部
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Kawamura Maki
Laboratory Of Pharmaceutical Proteomics National Institute Of Biomedical Innovation:department Of Bi
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Okamoto T
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University:departmen
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Kiwada Hiroshi
Department Of Pharmacokinetics And Biopharmaceutics Subdivision Of Biopharmaceutical Science Institu
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Yamamoto Yoko
Department Of Anesthesiology And Intensive Care Hamamatsu University School Of Medicine
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Saito Hiroyuki
Third Department Of Internal Medicine Asahikawa Medical College
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Nakagawa Shinsaku
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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TSUTSUMI Yasuo
Department of Electrical and Computer Engineering, Akashi National College of Technology
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Yoshioka Yasuo
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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