Amino Acids and Peptides.XXXVIII.Facile Synthesis of Laminin-Related Peptide-Poly(Ethylene Glycol)Hybrids by the Solid Phase Method
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概要
- 論文の詳細を見る
Poly(ethylene glycol)(PEG)has been studied as a drug-carrier for proteins, but not for small peptides. Laminin, a cell adhesive protein, has Tyr-Ile-Gly-Ser-Arg(YIGSR)sequence and peptides containing this sequence inhibit experimental metastasis. We have studied PEG hybrids of YIGSR and other small laminin-related peptides. In a previous paper, we reported preparation of YIGSR-PEG hybrids by combination of the solid phase method and the solution method, but the synthetic procedure was problematic. Here we report a facile synthesis of PEG hybrids of YIGSR(PEG-YIGSR, YIGSR-PEG, PEG-YIGSR-PEG)by the solid phase method.
- 公益社団法人日本薬学会の論文
- 2001-04-01
著者
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Mayumi Tadanori
Graduate School of Pharmaceutical Sciences, Kobe-Gakuin University
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Kiwada Hiroshi
徳島大学 ヘルスバイオサイエンス研究部薬物動態制御学
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Kiwada Hiroshi
Faculty Of Pharmaceutifal Sciences The University Of Tokushima
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真弓 忠範
Graduate School Of Pharmaceutical Sciences Kobe-gakuin Univ.
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村上 智彦
神戸学院大学 薬
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NAKAGAWA Shinsaku
Graduate School of Pharmaceutical Sciences, Osaka University
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Nakagawa S
Graduate School Of Pharmaceutical Sciences Osaka University
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Nakagawa Shinsaku
中華人民共和国
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Higashisaka Kazuma
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Kamada Haruhiko
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Kamada Haruhiko
Laboratory Of Pharmaceutical Proteomics (lpp) National Institute Of Biomedical Innovation (nibio)
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Yoshioka Yasuo
Department Of Radiation Oncology Osaka University Graduate School Of Medicine
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Yoshioka Yasuo
大阪大学 医学系研究科放射線治療学
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前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kiwada Hiroshi
Department Of Pharmacokinetics And Biopharmaceutics Faculty Of Pharmaceutical Sciences The Universit
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Yoshioka Yasuo
Dept. Of Radiation Oncology Osaka University Graduate School Of Medicine
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Tsujino Masaki
大阪大学 薬学研究科薬剤学
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Smith Timothy
School Of Pharmacy University Of Pacific
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川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Kamiya Hiroyuki
Lab. For Molecular Design Of Pharmaceutics Fac. Of Pharmaceutical Sciences Hokkaido Univ.
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Keiko Hojo
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Hojo Keiko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Maeda Mitsuko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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KAWASAKI Koichi
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
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Kamada H
Yamagata Technopolis Foundation Yamagata Jpn
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Kamada Hitoshi
Institute For Life Support Technology Yamagata Promotional Organization For Industrial Technology
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Yoshioka Yasuo
Dept. Of Energy Science And Engineering Musashi Inst. Of Tech.
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KAMADA Haruhiko
Graduate School of Pharmaceutical Sciences, Osaka University
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YAMAMOTO Yoko
Graduate School of Pharmaceutical Sciences, Osaka University
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Kawasaki Koichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Mayumi Tadanori
Faculty Of Pharmacy Osaka University
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Mayumi Tadanori
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Nakagawa Shinsaku
Graduate School Of Pharmaceutical Sciences Osaka University
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Kamada H
Institute For Life Support Technology Yamagata Promotional Organization For Industrial Technology
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Kiwada H
Faculty Of Pharmaceutifal Sciences The University Of Tokushima
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Yamashiro Y
Osaka Univ. Suita Jpn
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Mayumi Tadanori
Faculty Of Pharmaceutical Sciences Kobe-gakuin University:faculty Of Pharmaceutical Sciences Osaka U
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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Hojo Keiko
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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Kiwada Hiroshi
Department Of Pharmacokinetics And Biopharmaceutics Subdivision Of Biopharmaceutical Science Institu
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Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
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Nakagawa Shinsaku
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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