Anti-angiogenic Effects of Dimethyl Sulfoxide on Endothelial Cells(Pharmacognosy)
スポンサーリンク
概要
- 論文の詳細を見る
Dimethyl sulfoxide (DMSO) has anti-inflammatory and analgesic properties and is the only intravesical agent approved by the FDA for the treatment of interstitial cystitis. While it is known that DMSO has numerous biological effects on cell differentiation and alteration of cell-surface carbohydrate structures, the anti-inflammatory mechanism of DMSO has been not clear yet. Therefore, further investigation of DMSO in terms of inflammation therapy is needed. This study assessed the in vitro anti-angiogenic effects of DMSO on human aorta endothelial cells to clarify one of the mechanisms of its anti-inflammatory activity. DMSO did not affect expression of E-selectin on endothelial cells in the presence of TNF-alpha. Furthermore, DMSO effectively inhibited capillary tube formation; this mechanism would be due to suppression of matrix metalloproteinase-2 (MMP-2) production. These results provide useful knowledge about the anti-inflammatory effects of DMSO and the regulatory mechanism of MMP-2.
- 社団法人日本薬学会の論文
- 2003-09-01
著者
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Yoshioka Yasuo
Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka Unive
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Tsutsumi Yasuo
Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka Unive
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Mukai Yohei
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ
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Nakagawa Shinsaku
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka Univ
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提 康央
Faculty Of Pharmaceutical Sciences Osaka University
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真弓 忠範
Graduate School Of Pharmaceutical Sciences Kobe-gakuin Univ.
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真弓 忠範
大阪大学 薬 薬剤
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OKAMOTO Takayuki
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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MAYUMI Tadanori
Department of Cell Therapeutics, Graduate School of Pharmaceutical Sciences, Kobe Gakuin University
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村上 智彦
神戸学院大学 薬
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Nakagawa S
Graduate School Of Pharmaceutical Sciences Osaka University
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Nakagawa S
Osaka Univ. Osaka Jpn
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Nakagawa Shinsaku
中華人民共和国
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Mukai Yohei
Graduate School Of Pharmaceutical Sciences Osaka University
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Mukai Yohei
医薬基盤研究所 創薬プロテオミクスプロジェクト
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Tsutsumi Y
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Yoshioka Yasuo
Department Of Radiation Oncology Osaka University Graduate School Of Medicine
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Yoshioka Yasuo
大阪大学 医学系研究科放射線治療学
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Yoshioka Yasuo
Dept. Of Radiation Oncology Osaka University Graduate School Of Medicine
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Tsujino Masaki
大阪大学 薬学研究科薬剤学
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Morishita Yuki
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Morishita Yuki
大阪大学 薬学研究科毒性学
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KOIZUMI Keiichi
Department of Biopharmaceutics, School of Pharmaceutical Sciences, Osaka University
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Tsutsumi Yasuo
Department Of Electrical Engineering Akashi College Of Technology
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WATANABE Masaki
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University
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Yoshioka Yasuo
Dept. Of Energy Science And Engineering Musashi Inst. Of Tech.
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KOIZUMI Keiichi
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Mayumi Tadanori
Faculty Of Pharmacy Osaka University
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Mayumi Tadanori
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Mayumi Tadanori
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Science Osaka University
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Nakagawa Shinsaku
Dep. Of Biotechnology And Therapeutics Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Nakagawa Shinsaku
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University
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堤 康央
医薬基盤研究所:大阪大学大学院薬学研究科:大阪大学臨床医工学融合研究教育センター
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Yamashiro Y
Osaka Univ. Suita Jpn
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Okamoto Tatsuyuki
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University:departmen
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Mayumi Tadanori
Faculty Of Pharmaceutical Sciences Kobe-gakuin University:faculty Of Pharmaceutical Sciences Osaka U
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Tsutsumi Yasuo
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Momose T
大阪大学薬学部
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Koizumi Keiichi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Okamoto T
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University:departmen
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Watanabe Masaki
Department Of Applied Chemistry Graduate School Of Science And Engineering Ehime University
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Watanabe Masaki
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences Osaka University
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Nakagawa Shinsaku
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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TSUTSUMI Yasuo
Department of Electrical and Computer Engineering, Akashi National College of Technology
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Yoshioka Yasuo
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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