Nuclear Receptors as Targets for Drug Development : The Role of Nuclear Receptors During Neural Stem Cell Proliferation and Differentiation

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概要

• 論文の詳細を見る

• The fate of stem cells, such as neural stem cells and hematopoietic stem cells, depends on strictly regulated signaling events including activation of nuclear receptors, resulting in subsequent gene induction. Recently, we demonstrated that PPARγ, a ligand-activated nuclear receptor, plays an important role in regulating the proliferation and differentiation of murine neural stem cell (NSC). NSC prepared from heterozygous PPARγ-deficient mouse exhibited a slower growth rate compared with that of wild-type mouse, which was also demonstrated in PPARγ-knockdown NSC that was generated by the lentiviral-vector-mediated RNA interference approach. These studies have important implications for understanding central nervous system functions and developing a therapy for neurodegenerative disorders. In this review, recent findings on stem cell biology, especially focusing on nuclear receptors in NSCs, including our current study, will be discussed.

• 社団法人 日本薬理学会の論文
• 2005-02-20

著者

• MAYUMI Tadanori

  Department of Cell Therapeutics, Graduate School of Pharmaceutical Sciences, Kobe Gakuin University

• Nagane Yutaka

  Department Of Urology Sanai Hospital

• WADA Koichiro

  Department of Pharmacology, Graduate School of Dentistry, Osaka University

• Tajima Atsushi

  横浜市立大学 医学研究科消化器内科

• Nakajima Atsushi

  Division Of Gastroenterology Yokohama City University Graduate School Of Medicine

• Nakajima Atsushi

  理化学研究所ゲノム医科学研究センター 内分泌･代謝疾患チーム

• KAMISAKI Yoshinori

  Department of Pharmacology, Osaka University Graduate School of Dentistry

• NAKAJIMA Atsushi

  The Third Department of Internal Medicine, Yokohama City University School of Medicine

• Nakajima A

  Third Department Of Internal Medicine Faculty Of Medicine University Of Tokyo

• KATAYAMA KAZUFUMI

  Department of Pharmacology, Graduate School of Dentistry, Osaka University

• Wada Koichiro

  Department Of Mathematical And Computing Sciences Tokyo Institute Of Technology

• Mayumi Tadanori

  Department Of Biopharmaceutics Graduate School Of Pharmaceutical Science Osaka University

• Kamisaki Yoshinori

  Department Of Clinical Pharmacology Faculty Of Medicine Tottori University

• Wada Koichiro

  Department Of Pharmacology Osaka University And Graduate School Of Dentistry

• 上崎 善規

  Dep. Of Pharmacology Graduate School Of Dentistry Osaka Univ. Jpn

• Katayama K

  Department Of Biopharmaceutics Graduate School Of Pharmaceutical Science Osaka University

• Nakajima Atsushi

  The Third Department Of Internal Medicine Division Of Gastroenterology And Hepatology Kansai Medical

• Katayama Kazufumi

  Department of Biopharmaceutics, Graduate School of Pharmaceutical Science, Osaka University

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