Neutralizing Antibody Evasion Ability of Adenovirus Vector Induced by the Bioconjugation of Methoxypolyethylene Glycol Succinimidyl Propionate(MPEG-SPA)(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
Although adenovirus vectors (Ad) which possesses high transduction efficiency are widely used for gene therapy in animal models, clinical use is very limited. One of the main reason is that nearly 80% of human beings possess anti-Ad antibodies. In this study, we tried to modify Ad with methoxypolyethylene glycol (MPEG) activated by succinimidyl propionate, and, the neutralizing antibody evasion ability of PEGylated Ad was evaluated. The results demonstrated that PEG-Ad showed stronger protection ability against anti-Ad neutralizing antibody compared to that with unmodified-Ad. Considering there are many people carrying neutralizing antibody against Ad and readministration of Ad was necessary for treating chronic diseases, this strategy, which was also applicable to other vectors, can be used for developing improved vectors.
- 社団法人日本薬学会の論文
- 2004-06-01
著者
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Mayumi Tadanori
Graduate School of Pharmaceutical Sciences, Kobe-Gakuin University
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Eto Yusuke
Department Of Biotechnology And Therapeutics Graduate School Of Pharmaceutical Sciences Osaka Univer
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Eto Yusuke
Graduate School Of Pharmaceutical Sciences Osaka University
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Eto Yusuke
大阪大学 薬研究
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提 康央
Faculty Of Pharmaceutical Sciences Osaka University
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真弓 忠範
Graduate School Of Pharmaceutical Sciences Kobe-gakuin Univ.
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真弓 忠範
大阪大学 薬 薬剤
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HAYAKAWA Takao
National Institute of Health Sciences
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GAO Jian-Qing
College of Pharmaceutical Sciences, Zhejiang University
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村上 智彦
神戸学院大学 薬
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NAKAGAWA Shinsaku
Graduate School of Pharmaceutical Sciences, Osaka University
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TSUTSUMI Yasuo
Graduate School of Pharmaceutical Sciences, Osaka University
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Nakagawa S
Graduate School Of Pharmaceutical Sciences Osaka University
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Nakagawa S
Osaka Univ. Osaka Jpn
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Nakagawa Shinsaku
中華人民共和国
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Tsutsumi Y
Dep. Of Toxicology And Safety Sci. Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Gao Jian-qing
College Of Pharmaceutical Sciences Zhejiang University
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Tsujino Masaki
大阪大学 薬学研究科薬剤学
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Yu Jian-heng
Affiliated First Hospital Zhejiang University
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Gao J‐q
College Of Pharmaceutical Sciences Zhejiang University
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Gao Jian-qing
College Of Pharmaceutical Sciences Zhejiang University:graduate School Of Pharmaceutical Sciences Os
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GAO Jian-Qing
Graduate School of Pharmaceutical Sciences, Osaka University
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SEKIGUCHI Fumiko
Graduate School of Pharmaceutical Sciences, Osaka University
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KURACHI Shinnosuke
Graduate School of Pharmaceutical Sciences, Osaka University
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KATAYAMA Kazufumi
Graduate School of Pharmaceutical Sciences, Osaka University
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MIZUGUCHI Hiroyuki
Division of Cellular and Gene Therapy Products, National Institute of Health Sciences
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Hayakawa T
Pharmaceutical Res. And Technol. Inst. Kinki Univ.
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Mayumi Tadanori
Faculty Of Pharmacy Osaka University
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Mayumi Tadanori
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Nakagawa Shinsaku
Dep. Of Biotechnology And Therapeutics Graduate School Of Pharmaceutical Sciences Osaka Univ.
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Nakagawa Shinsaku
Graduate School Of Pharmaceutical Sciences Osaka University
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堤 康央
医薬基盤研究所:大阪大学大学院薬学研究科:大阪大学臨床医工学融合研究教育センター
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Mizuguchi Hiroyuki
Lab. Of Gene Transfer And Regulation National Inst. Of Biomedical Innovation
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Mayumi Tadanori
Faculty Of Pharmaceutical Sciences Kobe-gakuin University:faculty Of Pharmaceutical Sciences Osaka U
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Tsutsumi Yasuo
Dep. Of Biopharmaceutics Grad. Sch. Of Pharm. Sci. Osaka Univ.
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Momose T
大阪大学薬学部
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Sekiguchi F
Graduate School Of Pharmaceutical Sciences Osaka University
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Kaiho S
Graduate School Of Pharmaceutical Sciences Osaka University
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Katayama K
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Science Osaka University
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Mizuguchi H
Laboratory Of Gene Transfer And Regulation National Institute Of Biomedical Innovation:graduate Scho
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Mizuguchi Hiroyuki
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Gao Jian-qing
Inst. Of Pharmaceutics Coll. Of Pharmaceutical Sciences Zhejiang Univ.
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Nakagawa Shinsaku
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
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