Studies on Heterobifunctional Cross-Linking Reagents, 6-Maleimidohexanoic Acid Active Esters
スポンサーリンク
概要
- 論文の詳細を見る
6-Maleimidohexanoic acid N-hydroxysuccinimide ester has been used widely for preparation of enzyme immunoconjugates as a unique heterobifunctional cross-linking reagent. Its heterobifunctional reactivity is good, but its ester portion hydrolyzes easily in the presence of water. Several 6-maleimidohexanoic acid active esters (6-maleimidohexanoic acid 4-nitrophenyl ester, 6-maleimidohexanoic acid N-hydroxy-5-norbornene-endo-2, 3-dicarboximide ester, and 6-maleimidohexanoic acid pentafluorophenyl ester) were prepared and their reactivity and stability in an aqueous media were tested. Of the synthetic esters, the pentafluorophenyl ester exhibited the highest reactivity and stability in aqueous media.
- 公益社団法人日本薬学会の論文
- 2007-04-01
著者
-
Eto Yusuke
Department Of Biotechnology And Therapeutics Graduate School Of Pharmaceutical Sciences Osaka Univer
-
Eto Yusuke
Graduate School Of Pharmaceutical Sciences Osaka University
-
Eto Yusuke
大阪大学 薬研究
-
KIDA Shinya
Life Science Center, Faculty of Pharmaceutical Sciences, Kobe Gakuin University
-
NAKAGAWA Shinsaku
Graduate School of Pharmaceutical Sciences, Osaka University
-
Nakagawa S
Graduate School Of Pharmaceutical Sciences Osaka University
-
Nakagawa S
Osaka Univ. Osaka Jpn
-
Nakagawa Shinsaku
中華人民共和国
-
前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
川崎 紘一
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Keiko Hojo
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Hojo Keiko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Kida Shinya
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
-
Maeda Mitsuko
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
KAWASAKI Koichi
Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University
-
KIDA Shinya
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
-
Kawasaki Koichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
-
Nakagawa Shinsaku
Dep. Of Biotechnology And Therapeutics Graduate School Of Pharmaceutical Sciences Osaka Univ.
-
Nakagawa Shinsaku
Graduate School Of Pharmaceutical Sciences Osaka University
-
Kawasaki Keiko
Biological Science Laboratories Kao Corporation
-
Hojo Keiko
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
-
Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
-
Nakagawa Shinsaku
Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University
関連論文
- Optimized PEGylated Adenovirus Vector Reduces the Anti-vector Humoral Immune Response against Adenovirus and Induces a Therapeutic Effect against Metastatic Lung Cancer
- Amino Acids and Peptides. XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
- Amino Acids and Peptides. XXV. Preparation of Fibronectin-Related Peptide Poly(ethylene glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
- In Vitro and In Vivo Tumor Suppressive Activity Induced by Human Telomerase Transcriptase-Targeting Antisense Oligonucleotides Mediated by Cationic Liposomes(CELL AND TISSUE ENGINEERING)
- Cell-Penetrating Peptides as Adenovirus Vector Carrier
- Creation of Novel Cell-Penetrating Peptides for Intracellular Drug Delivery Using Systematic Phage Display Technology Originated from Tat Transduction Domain(Biochemistry)
- Non-Methylated CpG Motif Packaged into Fusogenic Liposomes Enhance Antigen-Specific Immunity in Mice(Highlighted paper selected by Editor-in-chief,Pharmacology)
- Vaccine Efficacy of Fusogenic Liposomes Containing Tumor Cell-Lysate against Murine B16BL6 Melanoma(Pharmacology)
- Anti-tumor Responses Induced by Chemokine CCL19 Transfected into an Ovarian Carcinoma Model via Fiber-Mutant Adenovirus Vector(Biopharmacy)
- Fusogenic Liposome can be Used as an Effective Vaccine Carrier for Peptide Vaccination to Induce Cytotoxic T Lymphocyte (CTL) Response(Biopharmacy)
- Amino Acids and Peptides. XXI. Laminin-Related Peptide Analogs Including Poly(Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
- Amino Acids and Peptides. XXIV. Preparation and Antinociceptive Effect of [D-Ala^2,(N-Me)Phe^4]Enkephalin Analog-Poly(Ethylene Glycol)Hybrids
- Amino Acids and Peptides. XXIII. Leu-Enkephalin Analogs Containing a Fluorinated Amino Acid at Position 2,4 or 5
- Human Chorionic Gonadotropin. VII. Preparation and Immunocharacteristics of Carboxyl-terminal Peptides of the β-Subunit of Human Chorionic Gonadotropin
- Human Chorionic Gonadotropin. II. Synthesis of a Hexadecapeptide corresponding to the C-Terminal Sequence 132-147 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
- 生理活性ペプチドの高分子ハイブリッド化 DDS - ポリスチレンマレイン酸によるラミニン関連細胞接着ペプチドのバイオコンジュゲーションとその癌転移抑制効果 -
- Amino Acids and Peptides. XXII. Preparation and Antinociceptive Effect of [D-Ala^2] Leu-Enkephalin-Poly (Ethylene Glycol) Hybrid
- Amino Acids and Peptides. XIX. Preparation of Enkephalin-Poly(ethylene glycol) Hybrid and Evaluation of Its Analgesic Activity
- Fast Binding Kinetics and Conserved 3D Structure Underlie the Antagonistic Activity of Mutant TNF : Useful Information for Designing Artificial Proteo-Antagonists
- Creation of Novel Protein Transduction Domain (PTD) Mutants by a Phage Display-Based High-Throughput Screening System(Biochemistry)
- Quality Enhancement of the Non-immune Phage scFv Library to Isolate Effective Antibodies(Highlighted paper selected by Editor-in-chief,Biochemistry)
- Development of Novel Drug Delivery System (DDS) Technologies for Proteomic-Based Drug Development
- Selective Enhancer of Tumor Vascular Permeability for Optimization of Cancer Chemotherapy (Pharmacognosy)
- Effective Cancer Targeting Using an Anti-tumor Tissue Vascular Endotheliumm specific Monoclonal Antibody (TES-23)
- Prolongation of the Effective Duration of Cytomedical Therapy by Re-injecting SK2 Hybridoma Cells Microencapsulated within Alginate-Poly(L)lysine-Alginate Membranes into Human Interleukin-6 Transgenic Mice
- Therapeutic Effect of Cytomedicine on Mesangio-Proliferative Glomerulonephritis in Human Interleukin-6 Transgenic Mice
- Synthesis of a Tetradecapeptide corresponding to Sequence 90-103 of Bovine Adrenodoxin
- Amino Acids and Peptides. I. Synthesis of a Model Peptide related to Iron-Sulfur Protein
- P1-582 模擬患者を活用した初年次教育の実践とその教育的成果(一般演題 ポスター発表,薬学教育(その他),臨床から学び臨床へと還元する医療薬学)
- Neutralizing Antibody Evasion Ability of Adenovirus Vector Induced by the Bioconjugation of Methoxypolyethylene Glycol Succinimidyl Propionate(MPEG-SPA)(Biopharmacy)
- Anti-angiogenic Effects of Dimethyl Sulfoxide on Endothelial Cells(Pharmacognosy)
- Preparation and Biological Activities of a Bivalent Poly(Ethylene Glycol) Hybrid Containing an Active Site and Its Synergistic Site of Fibronectin
- Tumor Necrosis Factor α-Gene Therapy for an Established Murine Melanoma Using RGD (Arg-Gly-Asp) Fiber-mutant Adenovirus Vectors
- Amino Acids and Peptides. X. : Leu-Enkephalin Analogues Containing a Fluorinated Aromatic Amino Acid
- Amino Acids and Peptides. IX. : Synthetic Studies on Leu-Enkephalin Analogues Containing a Ureylene Bond
- 3P-081 ファージ表面提示法を用いたTNFR1指向性リンフォトキシンαの創製とその特性評価(蛋白質工学,進化工学,第46回日本生物物理学会年会)
- Evaluation of Angiogenic Inhibitors with an in vivo Quantitative Angiogenesis Method Using Agarose Microencapsulation and Mouse Hemoglobin Enzyme-linked Immunosorbent Assay
- Selective Enhancement by Tumor Necrosis Factor-α of Vascular Permeability of New Blood Vessels Induced with Agarose Hydrogel-entrapped Meth-A Fibrosarcoma Cells
- A Quantitative in vivo Method of Analyzing Human Tumor-induced Angiogenesis in Mice Using Agarose Microencapsulation and Hemoglobin Enzyme-linked Immunosorbent Assay
- Amino Acids and Peptides. VII. : Preparation and Application of a Water-Soluble Active Ester, p-Trimethylammoniophenyl Ester
- Amino Acids and Peptides. IV. Synthesis and Analgesic Effects of Tyr-Containing Dipeptide Phenethylamides
- Effects of α-Linolenic Acid-rich Diacylglycerol on Diet-induced Obesity in Mice
- Effects of Tea Catechins on Diet-induced Obesity in Mice〔和文〕
- Enhancing Effect of α-Monoisostearyl Glyceryl Ether on the Percutaneous Penetration of Indomethacin through Excised Rat Skin
- Studies on Heterobifunctional Cross-Linking Reagents, 6-Maleimidohexanoic Acid Active Esters
- "Solid Phase Synthesis in Water" Using Fmoc-Amino Acid Nanoparticles
- Preparation and Characterization of Liposomes Encapsulating Chitosan Nanoparticles(Biopharmacy)
- Amino Acids and Peptides.XXXVIII.Facile Synthesis of Laminin-Related Peptide-Poly(Ethylene Glycol)Hybrids by the Solid Phase Method
- Indonesian Medicinal Plants. XVII. Characterization of Quassinoids from the Stems of Quassia indica
- Marine Natural Products. XXXVI. Biologically Active Polyacetylenes, Adociacetylenes A, B, C, and D, from an Okinawan Marine Sponge of Adocia sp.
- Production of Normal ↔ Macular Mouse Chimeras: The Presence of Critical Tissue in the Macular Mutant Mouse, a Model of Menkes' kinky Hair Disease
- Production of Chimeric Mice by Exchanging Nuclei from Blastomeres of the Two-Cell Embryo
- Conjugation of a Laminin-Related Antimetastatic Peptide with Chitosan (Part 3)
- Growth Inhibition of Human Leukemia HL-60 Cells by an Antisense Phosphodiester Oligonucleotide Encapsulated into Fusogenic Liposomes
- 29-P3-73 アメリカ薬学研修への新たな取り組み(No.2)(薬学教育,社会の期待に応える医療薬学を)
- Synthesis of Peptide Mimetics That Related to Tethered Thrombin Receptor and Their Agonist/Antagonist Activities on Platelet Aggregation
- Evaluation of a New N-Protecting Group, 2-(4-Sulfophenylsulfonyl)ethoxycarbonyl Group, for Solid Phase Peptide Synthesis in Water
- Peptide Synthesis in Water IV. Preparation of N-Ethanesulfonylethoxycarbonyl (Esc) Amino Acids and Their Application to Solid Phase Peptide Synthesis
- Solid Phase Synthesis in Water : Application of the Ethanesulfonylethoxycaronyl (Esc) Group
- Improved Preparation of an Amino Acid Type Poly(Ethylene Glycol) Derivative
- A New N-Protecting Group, 2-[Phenyl(methyl)sulfonio]ethyloxycarbonyl Tetrafluoroborate, and Its Application to Solid Phase Peptide Synthesis in Water
- Acylation of Hydrazides with Acetic Acid and Formic Acid
- 教育賞受賞 濱 堯夫氏の業績
- A Bivalent Poly (ethylene glycol) Hybrid Containing an Active Site (RGD) and a Synergistic Site of Fibronectin
- Amino Acids and Peptides. XXXV. Facile Preparation of p-Nitroanilide Analogs by the Solid-Phase Method
- A Facile Solid-Phase Synthesis of Peptide ρ-Nitroanilide Analogs
- Regioselective Conjugation of Chitosan with a Laminin-related Peptide, Tyr-Ile-Gly-Ser-Arg, and Evaluation of Its Inhibitory Effect on Experimental Cancer Metastasis
- Synthesis of Some Pseudo-Peptide Analogs of Thiol Proteinase Inhibitors
- Amino Acids and Peptides. VIII. : A Water-Soluble Active Ester, Phenolsulfonic Acid Derivative(Organic,Chemical)
- In vivo Anti-tumor Efficacy of Polyethylene Glycol-modified Tumor Necrosis Factor-α against Tumor Necrosis Factor-resistant Tumors
- Preferential Activity of Wild-type and Mutant Tumor Necrosis Factor-α against Tumor-derived Endothelial-like Cells
- Amino Acids and Peptides. XX. Preparation of β-Cyclododecyl Aspartate and Its Application to Synthesis of Fibronectin- and Laminin-Related Peptides
- Preparation of Laminin γ1 Chain Related Peptide Poly (Ethylene Glycol) Hybrid
- Amino Acids and Peptides. XXXI. Preparation of Analogs of the Laminin-Related Peptide YIGSR and Their Inhibitory Effect on Experimental Metastasis
- Amino Acids and Peptides. XXX. Preparation of Arg-Gly-Asp (RGD) Hybrids with Poly(Ethylene Glycol) Analogs and Their Antimetastatic Effect
- Amino Acids and Peptides. XXIX. Synthesis and Antimetastatic Effects of Peptides and Peptide-Poly(Ethylene Glycol) Hybrids Related to the Core Sequence of the Type III Connecting Segment Domain of Fibronectin
- Amino Acids and Peptides. XXVII. Solid Phase Synthesis of Fibrinogen-Related Peptides with Disulfide Bond Formed on Solid Support
- Preparation of Laminin-related Peptide Analogs and Their Inhibitory Effect on Experimental Metastasis in Mice
- The Carboxyl Terminal Sequence of Rat Transporter Associated with Antigen Processing (TAP)-Like (ABCB9) is Heterogeneous due to Splicing of Its mRNA(Biochemistry/Molecular Biology)
- Total Synthesis of (-)-Bulgecinine
- Samarium(II) Iodide-Mediated Intermolecular Coupling Reactions of N, N-Dibenzylenamides with Carbonyl Compounds and Transformation of the Product, N, N-Dibenzyl-γ-hydroxyamide to δ-Aminoalcohol
- Enhanced in Vitro Percutaneous Penetration of Salicylate by Ion Pair Formation with Alkylamines
- Amino Acids and Peptides. V. Synthesis of Amino Acid Derivatives Containing a Sulfonamide Bond
- Amino Acids and Peptides. XXVIII. Preparation of Poly(Ethylene Glycol)Hybrids of Gln-Val-Val-Ala-Gly Analogs and Their Inhibitory Effect on Papain
- A New Reagent, 2-[Phenyl(methyl)sulfonio]ethyl-4-nitrophenylcarbonate Tetrafluoroborate (Pms-ONp), for Preparation of Water-Soluble N-protected Amino Acids
- Membrane Localization of Transporter Associated with Antigen Processing (TAP)-Like (ABCB9) Visualized in Vivo with a Fluorescence Protein-Fusion Technique(Biochemistry/Molecular Biology)
- A Half-Type ABC TRansporter TAPL Is Highly Conserved between Rodent and Man, and the Human Gene Is Not Responsive to Interferon-γ in Contrast to TAP1 and TAP2^1
- Structures of P-type Transporting ATPases and Chromosomal Locations of Their Genes
- Isolation and Properties of Tumor-derived Endothelial Cells from Rat KMT-17 Fibrosarcoma
- Preparation of A Fibronectin-related Poly(Ethylene Glycol) Hybrid and Its Inhibitory Effect on Experimental Metastasis in Mice
- Amino Acids and Peptides. III. Synthesis of Model Peptides Related to Cytochrome P-450
- Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif(MEDICAL BIOTECHNOLOGY)
- The Opioid Activity and Receptor Selectivity of Fluorinated Leu^5 Enkephalin Analogues in Vitro and in Vivo
- Selectivity for Opioid Receptor Subtypes of Enkephalin Analogues in Isolated Smooth Muscle and in the Analgesic Effect in Mice
- INVOLVEMENT OF DIFFERENT RECEPTOR SUBTYPES FOR THE PRODUCTION OF IN VITRO AND IN VIVO EFFECTS IN A SERIES OF SYNTHETIC ENKEPHALIN ANALOGUES
- Microwave Assisted Solid-Phase Peptide Synthesis in Water Using Water-Dispersible Fmoc-Amino Acid NanoParticles
- プリオンタンパク質の銅結合部位
- Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif
- ラミニン由来ガン転移抑制ペプチドとキトサンとのハイブリッド体の調製
- In Vitro and In Vivo Tumor Suppressive Activity Induced by Human Telomerase Transcriptase-Targeting Antisense Oligonucleotides Mediated by Cationic Liposomes