Samarium(II) Iodide-Mediated Intermolecular Coupling Reactions of N, N-Dibenzylenamides with Carbonyl Compounds and Transformation of the Product, N, N-Dibenzyl-γ-hydroxyamide to δ-Aminoalcohol
スポンサーリンク
概要
- 論文の詳細を見る
Samarium(II) iodide-mediated intermolecular coupling reactions of N, N-dibenzylenamides (1a-d) with carbonyl compounds (2a-i) produced the corresponding N, N-dibenzyl-γ-hydroxyamides (3a-i) in moderate to good yields.Attempts to remove the two benzyl groups of 3a using hydrogenolysis and Birch reduction were unsuccessful. On the other hand, the lithium aluminum hydride reduction of 3a produced 10 in 61% yield, and dedibenzylation using 20% Pd(OH)_2 on carbon gave the corresponding δ-aminoalcohol (11).
- 公益社団法人日本薬学会の論文
- 1996-10-15
著者
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前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Aoyagi Y
Niigata Univ. School Of Medicine Niigata Jpn
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Aoyagi Yutaka
Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy
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Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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Fukaya Haruhiko
School of Pharmacy, Tokyo University of Pharmacy & Life Science
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Aoyagi Yutaka
School of Pharmacy, Tokyo University of Pharmacy & Life Science
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OHTA Akihiro
Tokyo University of Pharmacy and Life Science, School of Pharmacy
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Kubota K
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Ohta A
Faculty Of Science Shinshu University
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MAEDA Mikiko
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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OHTA AKihiro
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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MORO Akira
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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KUBOTA Ken
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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FUJII Yohko
School of Pharmacy, Tokyo University of Pharmacy and Life Science
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Moro Akira
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Fujii Yohko
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Fukaya H
Tokyo Univ. Pharmacy And Life Sci. Tokyo Jpn
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Fukaya Haruhiko
School Of Pharmacy Tokyo University Of Pharmacy And Life Sciences
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Aoyagi Y
Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy
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Ohta A
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
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Fukaya Haruhiko
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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