Apoptosis Induction by Lectin Isolated from the Mushroom Boletopsis leucomelas in U937 Cells(Biochemistry & Molecular Biology)

スポンサーリンク

概要

• 論文の詳細を見る

• A 15-kDa lectin was isolated from the edible mushroom Kurokawa by affinity chromatography using N, N'-diacetylchitobiose-Sepharose 4B. The results of microsequencing analysis indicated that the lectin has a partial amino acid sequence similar to the mushroom lectin, Agaricus bisporus agglutinin (ABA). We found that the Kurokawa lectin inhibited proliferation of human monoblastic leukemia U937 cells dose-dependently. Several lines of evidence indicated that this inhibition was due to its apoptosis induction. We observed that the lectin induced apoptotic bodies formation, chromatin condensation, and DNA ladder formation, features of apoptosis. The DNA ladder formation was inhibited by a general inhibitor of caspases, which are known to play essential roles in apoptosis. In contrast, ABA did not have cell growth-inhibiting or apoptosis-inducing activities. Thus, the Kurokawa lectin is the first mushroom lectin with apoptosis-inducing activity.

• 社団法人日本農芸化学会の論文
• 2002-04-23

著者

• 長谷 純宏

  阪大・理・化学

• 長谷 純宏

  大阪大学 大学院理学研究科化学専攻

• Koyama Y

  Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer

• Mega T

  Department Of Chemistry Graduate School Of Science Osaka University

• Aoyagi Y

  Niigata Univ. School Of Medicine Niigata Jpn

• Aoyagi Yutaka

  Department Of Third Internal Medicine Niigata University School Of Medicine

• Aoyagi Yutaka

  Department Of Radiology Tokyo Dental College

• Aoyagi Yutaka

  Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy

• Koyama Yu

  Cellular Biochemistry School Of Food And Nutritional Sciences University Of Shizuoka

• Koyama Yu

  Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer

• KOYAMA Yu

  School of Food and Nutritional Sciences and Center of Excellence for the 21st Century, University of

• ISEMURA Mamoru

  School of Food and Nutritional Sciences and Center of Excellence for the 21st Century, University of

• MITA Takashi

  School of Food and Nutritional Sciences, University of Shizuoka

• Mita T

  School Of Food And Nutritional Sciences University Of Shizuoka

• Mita Takashi

  Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer

• Munakata Hiroshi

  Department Of 2nd Biochemistry Kinki University School Of Medicine

• Koyama Yu

  School Of Food And Nutritional Sciences And Center Of Excellence For The 21st Century University Of

• Miyoshi Noriyuki

  School Of Food And Nutritional Sciences University Of Shizuoka

• Hayakawa S

  School Of Food And Nutritional Sciences University Of Shizuoka

• Hayakawa Sumio

  School Of Food And Nutritional Sciences University Of Shizuoka

• Hase Sumihiro

  Department Of Chemisty Graduate School Ofscience Osaka University

• Mita Takashi

  Department Of Chemistry Faculty Of Science And Technology Keio University

• KATSUNO Yuko

  School of Food and Nutritional Sciences, University of Shizuoka

• MUTO Haruhiko

  Shizuoka Prefecture Forestry and Forest Products Research Institute

• ISEMURA Satoko

  Nippon Dental University Junior College at Niigata

• Isemura S

  Nippon Dental University Junior College At Niigata

• Isemura Satoko

  Nippon Dental University Junior Collage At Niigata

• Aoyagi Y

  Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy

• 伊勢村 護

  Cellular Biochemistry School Of Food And Nutritional Sciences University Of Shizuoka

• Isemura Mamoru

  Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer

• Miyoshi Naoko

  School Of Food And Nutritional Sciences University Of Shizuoka

• Aoyagi Yutaka

  Department Of Gastroenterology And Hepatology Niigata University Graduate School Of Medical And Dent

• Mita T

  Tohoku Univ.

関連論文

• Purification and Characterization of D-Tagatose 3-Epimerase from Pseudomonas sp. ST-24
• トウアズキ(Abrus precatorius)種子毒蛋白質アブリンの糖鎖構造(生体高分子化学-多糖類, 核酸, 複合高分子-)
• Examination of growth promotion factors for smooth muscle cells of hypertrophied bladders in rats following partial outlet obstruction
• ヒト大脳のα-アミラーゼ活性
• Free Oligosaccharides with Lewis x Structure Expressed in the Segmentation Period of Zebrafish Embryo
• Alteration of Brain Type N-Glycans in Neurological Mutant Mouse Brain
• Co(II)-Regulated Substrate Specificity of Cytosolic α-Mannosidase
• Structural Analysis of N-Linked Sugar Chains of Human Blood Clotting Factor IX
• Processing Pathway Deduced from the Structures of N-Glycans in Carica papaya
• β1-4Galactosyltransferase Activity of Mouse Brain as Revealed by Analysis of Brain-Specific Complex-Type N-Linked Sugar Chains
• Quantitation and Isomeric Structure Analysis of Free Oligosaccharides Present in the Cytosol Fraction of Mouse Liver: Detection of a Free Disialobiantennary Oligosaccharide and Glucosylated Oligomannosides1
• A New Sugar Chain of the Proteinase Inhibitor from Latex of Carica papaya
• Partial Purification and Characterization of a Novel Endo-β-mannosidase Acting on N-Linked Sugar Chains from Lilium longflorum Thumb
• Detection of Man_5GlcNac and Related Free Oligomannosides in the Cytosol Fraction of Hen Oviduct
• 蛍光標識法による糖鎖の構造と機能の解析 (特集 プロジェクト研究)
• Development-Dependent Expression of Complex-Type Sugar Chains Specific to Mouse Brain
• Purification and Characterization of Neutral α-Mannosidase from Hen Oviduct: Studies on the Activation Mechanism of Co^
• オリゴ糖の生理活性とその構造解析 糖の精製と構造決定に関する最近の展開
• Improved Method for the Component Sugar Analysis of Glycoproteins by Pyridylamino Sugars Purified with Immobilized Boronic Acid
• 1.糖蛋白質の糖鎖構造解析へのNMRの応用(高分子構造解析への応用)
• Analysis by High-performance Anion-exchange Chromatography of Component Sugars as Their Fluorescent Pyridylamino Derivatives(Analytical Chemistry)
• 複合糖質の糖鎖研究における新しい方法論とその展望--ピリジルアミノ化法の役割
• Improved Method for Fluorescence Labeling of Sugar Chains with Sialic Acid Residues(Analytical Chemistry)
• 糖蛋白質の糖鎖構造解析 (バイオサイエンスの潮流--方法論とタ-ゲット) -- (近未来に何が期待されているか)
• 糖鎖構造解析の高感度化--ピリジルアミノ化による少糖の蛍光標識--ナノモル,ピコモルオ-ダ-の微量分析が可能
• 生物化学--糖タンパク質の糖鎖構造決定法 (1979年の化学-10-)
• Comparative Biochemical Study of N-Linked Glycans from Skin of a Squid, Todarodes pacificus
• Characterization of Wheat Germ Agglutinin Ligand on Soluble Glycoproteins in Caenorhabditis elegans
• Structural Analysis of N-Linked Glycans in Caenorhabditis elegans
• Conversion of Pyridylamino Sugar Chains to Corresponding Reducing Sugar Chains
• 5-Aminolevulinate Synthase Expression and Hemoglobin Synthesis in a Human Myelogenous Leukemia Cell Line^1
• Blockade of interferon-γ-inducible protein-10 attenuates chronic experimental colitis by blocking cellular trafficking and protecting intestinal epithelial cells
• Acute dissection of the innominate artery : A case of report
• 1 Clinical Experience of Endovascular Stent-grafting for Thoraci c Aorta(Stent-graft for Aortic aneurysms and Dissections:results of clinical application, indication, recent advancement, and future perspective,Meet the Expert 2 (ME2) (IHD),The 70th Annive
• Stimulation of IL-8 Production by Aralia cordate Lectin in Human Colon Carcinoma Caco-2 Cells
• Isolation of Lectins by Affinity Chromatography with Porcine Plasma Proteins Immobilized on Agarose(Biochemistry & Molecular Biology)
• Characterization of an Apoptosis-Inducing Factor in Habu Snake Venom as a Glycyrrhizin (GL)-binding Protein Potently Inhibited by GL in VItro
• Role of the Heme Regulatory Motif in the Heme-Mediated Inhibition of Mitochondrial Import of 5-Aminolevulinate Synthase
• Detection of UDP-D-Xylose: α-D-Xyloside α1→3Xylosyltransferase Activity in Human Hepatoma Cell Line HepG2^1
• Identification of Trisaccharide Xy1α1→3Xy1α1→3Glc in Human Urine
• Isolation and Characterization of an N-Linked Oligosaccharide That Is Significantly Increased in Sera from Patients with Non-Small Cell Lung Cancer
• Purification and Substrate Specificity of UDP-D-xylose : β-D-Glucoside α-1,3-D-Xylosyltransferase Involved in the Biosynthesis of the Xylα1-3Xylα1-3Glcβ1-O-Ser on Epidermal Growth Factor-like Domains
• A Novel α1,2-L-Fucosidase Acting on Xyloglucan Oligosaccharides is Associated with Endo-β-Mannosidase
• A Retaining Endo-β-Mannosidase from a Dicot Plant, Cabbage
• Apoptosis-inducing Activity of High Molecular Weight Fractions of Tea Extracts
• Cloning and Sequencing of a Gene Encoding D-Aminoacylase from Alcaligenes xylosoxydans subsp. xylosoxydans A-6 and Expression of the Gene in Escherichia coli
• Regular Exercise Improves Insulin Sensitivity, Physical Activity, and Psychosocial Status in Patients with Chronic Liver Diseases
• Effect of Alkylpyrazine Derivatives on the Duration of Pentobarbital-Induced Sleep, Picrotoxicin-Induced Convulsion and γ-Aminobutyric Acid(GABA)Levels in the Mouse Brain
• Anti-Platelet Aggregation Activity of Some Pyrazines
• Total Synthesis of (-)-Bulgecinine
• Samarium(II) Iodide-Mediated Intermolecular Coupling Reactions of N, N-Dibenzylenamides with Carbonyl Compounds and Transformation of the Product, N, N-Dibenzyl-γ-hydroxyamide to δ-Aminoalcohol
• Apoptosis Induction by Lectin Isolated from the Mushroom Boletopsis leucomelas in U937 Cells(Biochemistry & Molecular Biology)
• Apoptosis Induction Associated with Cell Cycle Dysregulation by Rice Bran Agglutinin
• A Fibronectin-binding Protein from Rice Bran with Cell Adhesion Activity for Animal Tumor Cells
• Bilirubin Binding Activity of Cytokeratin 18 Isolated from the Porcine Liver
• Inhibition of Collagenases from Mouse Lung Carcinoma Cells by Green Tea Catechins and Black Tea Theaflavins
• Enantioselective 1, 3-Dipolar Cycloaddition Reaction of Nitrones with α, β-Unsaturated Aldehydes Catalyzed by Cationic 3-Oxobutylideneaminatocobalt(III) Complexes
• Highly Active 3-Oxobutylideneaminatocobalt Complex Catalysts for an Enantioselective Hetero Diels-Alder Reaction
• Opitcally Active Cationic Cobalt(III) Complexes: Highly Efficient Catalysts for Enantioselective Hetero Diels-Alder Reaction
• Evidence for Spontaneous Cycloaromatization of Nine-Membered Monocyclic Enediyne
• Decreased Expression of Catechol-O-Methyltransferase in the Renal Cortex of Malignant Spontaneously Hypertensive Rats
• Transforming Growth Factor-β Upregulates the Expression of Integrin and Related Proteins in MRC-5 Human Myofibroblasts
• MORPHOLOGICAL CHANGE AND INACTIVATION OF HUMAN LUNG MYOFIBROBLASTS CULTURED IN CONDITIONED MEDIUM OF HUMAN LUNG CARCINOMA
• Isolation of a 41-kDa Protein with Cell Adhesion Activity for Animal Tumor Cells from the Mushroom Hypsizigus marmoreus by Affinity Chromatography with Type IV Collagen Immobilized on Agarose
• High Transverse Momentum of Atmospheric γ-Ray Bundles (>10^eV) Estimated from Their RE Distributions
• Interaction between the Carboxyl-terminal Heparin-binding Domain of Fibronectin and (-)-Epigallocatechin Gallate
• Apoptosis-inducing Activity of Polyphenol Compounds Derived from Tea Catechins in Human Histiolytic Lymphoma U937 Cells
• Microwave Interstitial Hyperttierraia with Ablation Concept: Based on the Heating and Clinical Results of Five Cases
• Cloning and Nucleotide Sequence of the Mycodextranase Gene from Streptomyces sp. J-13-3(Biochemistry & Molecular Biology)
• Purification and Properties of Chitinase from Arthrobacter sp. NHB-10
• Identification of Licocoumarone as an Apoptosis-Inducing Component in Licorice(Miscellaneous)
• Biochemical Characterization of 60S Acidic Ribosomal P Proteins from Porcine Liver and the Inhibition of Their Immunocomplex Formation with Sera from Systemic Lupus Erythematosus (SLE) Patients by Glycyrrhizin in Vitro
• Separation of Phospholipase A_2 in Habu Snake Venom by Glycyrrhizin (GL)-Affinity Column Chromatography and Identification of a GL-Sensitive Enzyme
• A 96-kDa Glycyrrhizin-Binding Protein (gp96) from Soybeans Acts as a Substrate for Casein Kinase II, and Is Highly Related to Lipoxygenase 3
• Connective Tissue Growth Factor Cooperates with Fibronectin in Enhancing Attachment and Migration of Corneal Epithelial Cells
• Effect of Monensin on the Synthesis of β-D-Xyloside-Initiated Glycosaminoglycan and Its Linkage Region Oligosaccharides in Human Skin Fibroblasts
• Epigallocatechin-3-O-gallate Inhibits Fibroblast Contraction of Floating Collagen Gel : Interaction between Epigallocatechin-3-O-gallate and Platelet Derived Growth Factor
• Evidence for the Interaction between (-)-Epigallocatechin Gallate and Human Plasma Proteins Fibronectin, Fibrinogen, and Histidine-rich Glycoprotein
• Cloning and Expression of the Sarcosine Oxidase Gene from Bacillus sp. NS-129 in Escherichia coli(Biological Chemistry)
• Cloning and Expression of the Creatinase Gene from Flavobacterium sp. U-188 in Escherichia coli(Microbiology & Fermentation Industry)
• Comparative Analysis by Frontal Affinity Chromatography of Oligosaccharide Specificity of GlcNAc-Binding Lectins, Griffonia simplicifolia Lectin-II (GSL-II) and Boletopsis leucomelas Lectin (BLL)
• Difference in Laminin Expression Between High and Low Metastatic Cell Clones Derived from Murine Lewis Lung Carcinoma
• Apoptosis-Inducing Activity of Lipid Derivatives of Gallic Acid
• DOMAIN STRUCTURE OF CHONDROITIN SULFATE OCTASACCHARIDES BINDING TO TYPE V COLLAGEN
• Haeme-regulated Degradation of δ-Aminolevulinate Synthase 1 in Rat Liver Mitochondria
• Carbohydrate Specificity of Lectins from Boletopsis leucomelas and Aralia cordate
• Apoptosis-inducing Activity of a Driselase Digest Fraction of Green Tea Residue
• Chimeric Glycosaminoglycan Oligosaccharides Synthesized by Enzymatic Reconstruction and Their Use in Substrate Specificity Determination of Streptococcus Hyaluronidase
• What can be identified by three-phase bone scintigraphy in patients with chronic osteomyelitis of the mandible?
• Hepatic Fatty Acid-Binding Proteins of a Teleost, Lateolabrax japonicus. The Primary Structures and Location of a Disulfide Bond^1
• Cloning and Sequencing of the L-Fucose Dehydrogenase Gene from Pseudomonas sp.No. 1143
• The cancer stem cell marker CD133 is a predictor of the effectiveness of S1+ pegylated interferon α-2b therapy against advanced hepatocellular carcinoma
• Purification and Characterization of Novel N-Acyl-D-aspartate Amidohydrolase from Alcaligenes xylosoxydans subsp. xylosoxydans A-6
• Three Domains Comprised in Thermostable Molecular Weight 54,000 Pullulanase of Type I from Bacillus flavocaldarius KP1228
• Factor H Is a Dermatan Sulfate-Binding Protein : Identification of a Dermatan Sulfate-Mediated Protease That Cleaves Factor H
• 蛍光標識法による糖鎖解析 (糖鎖生物学の進歩と工学的応用)
• 植物糖蛋白質の糖鎖構造--キシロ-スとフコ-スを含む共通糖鎖構造(今日の話題)
• Aortic Conduit Valve Model With Controlled Moderate Aortic Regurgitation in Rats:– A Technical Modification to Improve Short- and Long-Term Outcome and to Increase the Functional Results –
• Activation of c-Jun N-terminal kinase in non-cancerous liver tissue predicts a high risk of recurrence after hepatic resection for hepatocellular carcinoma
• Apoptosis Induction Associated with Cell Cycle Dysregulation by Rice Bran Agglutinin.

もっと見る 閉じる

スポンサーリンク