Stimulation of IL-8 Production by Aralia cordate Lectin in Human Colon Carcinoma Caco-2 Cells
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概要
- 論文の詳細を見る
Some lectins are known to stimulate interleukin-8 (IL-8) productions in human colon carcinoma Caco-2 cells. Since IL-8 may cause deleterious effects, we examined this stimulatory activity of Aralia cordate lectin (ACL) and Wasabia japonica lectin (WJL), both of which we isolated recently. The results indicate that ACL exhibited strong stimulatory activity for IL-8 protein production, while WJL showed marginal activity. The activity of ACL was associated with high enhancement of IL-8 gene expression. The effect of ACL was abolished almost completely in the presence of brefeldin A, indicating that internalization into cells is necessary for ACL to exert activity. The findings suggest that ingestion of a large amount of raw vegetable Aralia cordate might cause unfavorable effects on the colon.
- 社団法人 日本農芸化学会の論文
- 2005-01-23
著者
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Kajiya Akane
静岡県立大学 食品栄養科学部
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Kajiya Akane
School Of Food And Nutritional Sciences And Center Of Excellence For The 21st Century University Of
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Koyama Y
Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer
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Koyama Yu
Cellular Biochemistry School Of Food And Nutritional Sciences University Of Shizuoka
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Koyama Yu
Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer
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KOYAMA Yu
School of Food and Nutritional Sciences and Center of Excellence for the 21st Century, University of
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SUZUKI Takuji
School of Food and Nutritional Sciences and Center of Excellence for the 21st Century, University of
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ISEMURA Mamoru
School of Food and Nutritional Sciences and Center of Excellence for the 21st Century, University of
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Suzuki Takuji
Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer
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Koyama Yu
School Of Food And Nutritional Sciences And Center Of Excellence For The 21st Century University Of
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伊勢村 護
Cellular Biochemistry School Of Food And Nutritional Sciences University Of Shizuoka
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Isemura Mamoru
Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer
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