Inhibition of Collagenases from Mouse Lung Carcinoma Cells by Green Tea Catechins and Black Tea Theaflavins
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概要
- 論文の詳細を見る
Theaflavin and theaflavin digallate, which are components of black tea were examined by in vitro invasion assay with mouse Lewis lung carcinoma LL2-Lu3 cells, which are highly metastatic. The compounds inhibited invasion by the tumor cells. Gelatin zymography showed that the cells secreted matrix metalloproteinases (MMPs), probably including MMP-2 and MMP-9, which may be involved in tumor cell invasion and metastasis. Theaflavin and theaflavin digallate also inhibited MMPs from the culture medium of these tumor cells, as did (-)-epigallocatechin gallate. These results suggest that theaflavin, theaflavin digallate, and (-)-epigallocatechin gallate inhibit tumor cell invasion by inhibiting type IV collagenases of the LL2-Lu3 cells.
- 社団法人日本農芸化学会の論文
- 1997-09-23
著者
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HARA YUKIHIKO
Food Research Laboratories, Mitsui Norin Co., Ltd.
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Hara Yukihiko
Food Research Institute Mitsui Norin Co. Ltd.
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Mega T
Department Of Chemistry Graduate School Of Science Osaka University
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ISEMURA Mamoru
School of Food and Nutritional Sciences and Center of Excellence for the 21st Century, University of
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MITA Takashi
School of Food and Nutritional Sciences, University of Shizuoka
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Mita T
School Of Food And Nutritional Sciences University Of Shizuoka
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Mita Takashi
Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer
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Mita Takashi
Department Of Chemistry Faculty Of Science And Technology Keio University
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SHOJI Yutaka
School of Food and Nutritional Sciences, University of Shizuoka
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SAZUKA Masaki
School of Food and Nutritional Sciences, University of Shizuoka
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IMAZAWA Hirokazu
School of Food and Nutritional Sciences, University of Shizuoka
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Shoji Y
Kyushu Univ. Fukuoka Jpn
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Sazuka M
Univ. Shizuoka Shizuoka Jpn
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Sazuka Masaki
School Of Food And Nutritional Sciences University Of Shizuoka
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伊勢村 護
Cellular Biochemistry School Of Food And Nutritional Sciences University Of Shizuoka
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Isemura Mamoru
Laboratory Of Cellular Biochemistry Graduate School Of Nutritional And Environmental Sciences Univer
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Hara Yukihiko
Food Research Institute Mitsui Norin Co.
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Imazawa Hirokazu
School Of Food And Nutritional Sciences University Of Shizuoka
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Mita T
Tohoku Univ.
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